MS and elevated liver enzymes

Post by **jimmylegs** » Fri May 30, 2008 7:39 am

on zinc, membranes, and the liver:

http://www.pubmedcentral.nih.gov/articl ... id=1375257
Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation.

http://jpet.aspetjournals.org/cgi/conte ... /305/3/880
Prevention of Alterations in Intestinal Permeability Is Involved in Zinc Inhibition of Acute Ethanol-Induced Liver Damage in Mice

http://jn.nutrition.org/cgi/content/full/130/5/1388S
Zinc Deficiency, Malnutrition and the Gastrointestinal Tract

http://linkinghub.elsevier.com/retrieve ... 4302044177
Effect of zinc supplementation on intestinal permeability in experimental colitis .

http://lpi.oregonstate.edu/ss03/zinc.html
The Antioxidant Function of Dietary Zinc and Protection Against Neural Disorders

http://www.ebmonline.org/cgi/content/full/223/2/175
Zinc Deficiency Exacerbates Loss in Blood-Brain Barrier Integrity Induced by Hyperoxia Measured by Dynamic MRI

http://www.pubmedcentral.nih.gov/articl ... id=1083158
Zinc and copper in multiple sclerosis.

http://www.ingentaconnect.com/content/k ... 7/00009462
Zinc and the Liver: An Active Interaction

http://www.springerlink.com/content/h587445872627656/
Protective effect of zinc on liver injury induced byd -galactosamine in rats

nasty sounding research, but interesting...
http://jn.nutrition.org/cgi/content/abs ... 24/10/1917
Dietary Fat Influences the Effect of Zinc Deficiency on Liver Lipids and Fatty Acids in Rats Force-Fed Equal Quantities of Diet

what is the deal with all these rats...
http://www.grupoaulamedica.com/web/nutr ... ginal3.pdf
Protective effects of zinc on oxidative stress enzymes in liver of protein
deficient rats

yes, there certainly can be too much of a good thing, there is such a thing as zinc toxicity, but it's worth getting tested i reckon. there seems to be quite a bit of debate in the research about zinc and ms specifically. i don't have it pieced together yet. the best bet site says lots of ppl with ms have zinc deficiency. the literature doesn't really seem to support that contention. but i got tested and was quite seriously deficient... so from where i sit the science can debate all it wants.

Post by **jimmylegs** » Fri May 30, 2008 8:29 am

http://www.nature.com/mt/journal/v11/n1 ... 5766a.html
Zinc Finger Protein Transcription Factors as Potential Therapeutic Agents for the Treatment of Neuropathic Pain

http://www.thisisms.com/ftopic-reply-5595.html
Depletion of vesicular zinc in dorsal horn of spinal cord causes increased neuropathic pain in mice

DIM · Post by **DIM** » Fri May 30, 2008 2:57 pm

Jimmy my wife takes daily 50mg zinc and when last few days she had a blood test found zinc level exactly in the middle of normal levels, quite interesting her hormones and most of blood indexes came at the middle of normal levels, ECXEPT liver enzymes thus my worries!
Even her older blood tests were much worse than current which means LDN, diet and supplementation did helped her!

Jeff's liver enzymes have been up only once again since his diagnosis, and most of his petechiae have faded to orange, but I still am trying to put all the pieces together. He's pretty stable, but deals with daily leg pain, fatigue and brain fog. It's certainly not fun. Hang in there, Dim!
best

Dear AC
My wife never had fatique issues probably due to LDN and training with a vibro machine that stopped last few weeks due to her colds and our try to get pregnant, fortunately today she walked a long distance in the sun (32 celcius degrees ambient!!!) without problem which encourages me as probably means her fatique diminishes.
I bought more than 5 boxes silymarin along with liquorice and other detox substances and just delivered the N-acetyl cysteine with the hope her new blood test in a month show lowering AST/ALT levels, hope!

Post by **jimmylegs** » Fri May 30, 2008 3:35 pm

that's great that she's got that good zinc regimen. i forget does she have results for uric acid too?

DIM · Post by **DIM** » Tue Jun 03, 2008 10:47 pm

jimmylegs wrote:that's great that she's got that good zinc regimen. i forget does she have results for uric acid too?

Upper normal levels Jimmy, 6 when normal range is - if I remember right - between 1.9-7!

Post by **jimmylegs** » Wed Jun 04, 2008 6:25 am

very good

i'm hoping that mine will have normalized also.