Allo-HSCT: Doesn't Stop Inflam or Demyelination

[Shayk]

Here's an interesting abstract that popped up on Pub Med today.

Neuroinflammation and demyelination in multiple sclerosis after allogeneic hematopoietic stem cell transplantation

RESULTS: Demyelinating and inflammatory activities of MS persisted after allo-HSCT in all of the patients with MS.

CONCLUSION: Allo-HSCT fails to halt the demyelination and inflammation of MS

Maybe that will be the end of that.

Sharon

[rainer]

I wouldn't expect a study with 4 MS patients who died 4.5 months after the transplant to be the definitive answer on much of anything.

. The normal-appearing brains of allo-HSCT recipients who did not have MS were found to have significantly higher numbers of CD3(+) T cells and CD8(+) cytotoxic T cells and higher scores of CD68(+) microglia/macrophages compared with the controls; however, no demyelination was identified in these non-MS samples.

Also interesting that they found neural inflammation in the non-ms patients who had the procedure.

[mmonica]

Maybe that will be the end of that.

Sharon

I hope not, this study isnt enough to prove anything.....


Monica

[mmonica]

http://msj.sagepub.com/cgi/content/abstract/16/6/685

I dont hope this is the end of that. I hope it continues conversations, research and debate