Low Neutrophil

[Bubba]

Does anyone know anything about Low Neutrophil? Does it relate to MS? Our oldest daughter (20 yoa) has to go in for a bone marrow biopsy friday? I have done some research and seen some links to MS. Can anyone shed some light on this?

[Lyon]

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[Cece]

Hope they find some answers with the biopsy. Low neutrophil is not commonly associated with multiple sclerosis, except as a possible side effect if a pwMS is on a powerful immunosuppressant.

[patientx]

Hope it's nothing too serious, Bubba. What led to them finding the low neutrophils, and having to do the biopsy?

[jimmylegs]

hi bubba i found this so far:

Essentiality of copper in humans
American Journal of Clinical Nutrition, Vol 67, 952S-959S, Copyright © 1998 by The American Society for Clinical Nutrition, Inc
Diets in Western countries provide copper below or in the low range of the estimated safe and adequate daily dietary intake. Copper deficiency is usually the consequence of decreased copper stores at birth, inadequate dietary copper intake, poor absorption, elevated requirements induced by rapid growth, or increased copper losses. The most frequent clinical manifestations of copper deficiency are anemia, neutropenia, and bone abnormalities.

www.neutropenia.ca/about/index.html
About Neutropenia - Neutropenia Support Association Inc.

The term neutropenia describes the situation where the number of neutrophils in the blood is too low

contains info on a bajillion types of neutropenia, including congenital and acquired types, with this tidbit related to nutrition:
http://emedicine.medscape.com/article/204821-overview

Nutritional deficiencies include vitamin B-12, folate, and copper deficiency

.
i had a quick look at the B12 and folate side of things and am less certain that they are involved to the same degree as copper. i'd go to copper as a potential nutritional suspect first.

now to figure out how to evaluate a copper test result... what is a healthy copper level?:
http://tinyurl.com/237mnb9
Determination of copper levels in serum of healthy subjects by atomic absorption spectrometry

Abstract
Copper levels in serum samples of 84 healthy subjects living in southeastern Spain were determined using the flame atomic absorption spectrometry technique... Mean copper concentrations were 1.092 ± 0.365 mg/l (with the range 0.304–2.000 mg/l) and 1.113 ± 0.253 mg/l (corresponding to an interval of 0.648–1.760 mg/l) for women and men, respectively ... Estimated daily dietary intakes on copper in women and men were 1.38 and 2.10 mg Cu/day respectively.

looks like 1.100 mg/L might be a good target. i have other copper studies kicking around somewhere.. i'll dig them up and we can compare mean values in healthy people to see if there's general academic agreement on a 'sweet spot' inside the normal range.

so with all that said, you may wish to suggest a copper test. remember, if the test gets done, don't let them tell her it's normal! get the result including units, and we can see if it lines up with healthy subjects or not.

best wishes for your daughter, bubba

[LR1234]

When my nutrophils are low my MS tends to be quiet. When I had a bad vertigo relapse the only blood test that came back raised was the nutrophils.

[jimmylegs]

L sounds like there's a scale from neutropenia to neutrophila, with a smaller range in between which is probably low for you, high for those with neutropenia, and normal for healthy subjects.

http://emedicine.medscape.com/article/956278-overview
Increased release of neutrophils from marrow: This occurs in infection, stress, and hypoxia;

what were some of these neutrophil resuls floating around? i had elevated neutrophils once.. ill look it up and post.

normal mean value in adults:
4.4 (1.8-7.7) 10^9 \L or thousands per μ L
still need another step to find 'healthy controls'

[Bubba]

It was an annual physical she had. Her white cell blood count was low. They sent her to a blood doctor. He tested her once a month for six months. After the last text, we got a phone call from him that she needed to come to his office right away. He said her neutrophil level was almost zero. He wanted to rule out leukemia. So, he ordered her the bone marrow biopsy, wich she had today. I am praying the results come back good...

[jimmylegs]

hi bubba hope the answer is good news. do you think they'll do a copper test at all?
FYI

Serum selenium and zinc concentrations were lower in leukemia patients than those of controls (p<0.01). Serum copper concentration was higher in leukemia patients than that of controls (p<0.01).

[patientx]

It was an annual physical she had. Her white cell blood count was low. They sent her to a blood doctor. He tested her once a month for six months. After the last text, we got a phone call from him that she needed to come to his office right away. He said her neutrophil level was almost zero. He wanted to rule out leukemia. So, he ordered her the bone marrow biopsy, wich she had today. I am praying the results come back good...

We'll be praying along with you Bubba.

[LR1234]

Bubba I hope everything is ok x