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Cell Stress Chaperones. 2010 Aug 30. [Epub ahead of print] Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: a review and comparison to other methods of detection in thoracic aneurysm repair.
Hecker JG, McGarvey M.
Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 Morgan, 3620 Hamilton Walk, Philadelphia, PA, 19104-6112, USA, heckerj@uphs.upenn.edu.
Abstract
The heat shock proteins (HSPs) are members of highly conserved families of molecular chaperones that have multiple roles in vivo. We discuss the HSPs in general, and Hsp70 and Hsp27 in particular, and their rapid induction by severe stress in the context of tissue and organ expression in physiology and disease. We describe the current state of knowledge of the relationship and interactions between extra- and intracellular HSPs and describe mechanisms and significance of extracellular expression of HSPs. We focus on the role of the heat shock proteins as biomarkers of central nervous system (CNS) ischemia and other severe stressors and discuss recent and novel technologies for rapid measurement of proteins in vivo and ex vivo. The HSPs are compared to other proposed small molecule biomarkers for detection of CNS injury and to other methods of detecting brain and spinal cord ischemia in real time. While other biomarkers may be of use in prognosis and in design of appropriate therapies, none appears to be as rapid as the HSPs; therefore, no other measurement appears to be of use in the immediate detection of ongoing severe ischemia with the intention to immediately intervene to reduce the severity or risk of permanent damage.
Results - The mean HSP27 level was 12.41 ± 18.21 ng/ml in the attack phase, 4.58 ± 4.75 ng/ml during remission, and 2.58 ± 3.88 ng/ml in control patients. The heat shock proteins (HSP) levels of MS patients in the attack phase were significantly higher than those obtained in the remission phase (P = 0.005).
Wouldn't it be something if after the procedure the MS patients could get these heat shock proteins down to the level of the control patients! Ikulo, great find.
what about us that carry the name ppms. a steady decline. in 20 yrs. i have never experienced a relapse or remission. just steady downhill. maybe i overlooked some of the read. is there anything where they have tested the dragon with 10 heads called ppms?