Summary: The study aims to correlate diffusion tension imaging (DTI) findings with disease activity, lesion burden, and cognitive processing speed in children.
MS participants displayed lower fractional anisotropy (FA) values in corpus callosum and in normal-appearing white matter (NAWM) versus controls. Higher lesion volumes correlated with reduced FA in the corpus callosum and hemispheric NAWM but DTI metrics did not correlate with disability. FA values in corpus callosum regions did however correlate with cognitive speed tasks in MS participants only. Overall the authors conclude that the results suggest an early onset tissue pathology in MS and illustrate its functional consequence.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1408