BG12
BG12
Could someone remind me of what BG12 is actually?? I know its fumeric acid or something like that but I read somewhere on this forum that it can be synthesised via a supplement but just can't find the post.
Thanks
Thanks
Re: BG12
Fumaric acid is a metabolite involved in the citric acid cycle in mitochondria. BG12 is the dimethyl ester of fumaric acid or dimethyl fumarate. BG12 induces oxidative stress in the cell and causes it to switch into defense mode by activating the transcription factor Nrf2. Once activateed, Nrf2 goes into the nucleus and turns on the transcription of several genes for cellular detox antioxidant enzymes. There are abundant molecules in nature that have a similar function. One example is curcumin from turmeric, but there are many more.LR1234 wrote:Could someone remind me of what BG12 is actually?? I know its fumeric acid or something like that but I read somewhere on this forum that it can be synthesised via a supplement but just can't find the post.
Here is the chemical structure of dimethyl fumarate.
Compare the above structure to those depicted in figure 2 of this free review paper on Nrf2 activators.
https://www.thieme-connect.com/ejournal ... 088302.pdf
Here are some links to some prior posts which discuss BG12 and Nrf2.
BG12 at Ectrims
http://www.thisisms.com/forum/general-d ... 18288.html
BG12 Efficacy
http://www.thisisms.com/forum/gilenya-f ... ml#p173498
BG12 Activity
http://www.thisisms.com/forum/chronic-c ... ml#p188961
Curcumin's pro-oxidant activity
http://www.thisisms.com/forum/natural-a ... ml#p188097
Old treaments, new tricks
http://www.thisisms.com/forum/general-d ... 17487.html
There are other posts and threads, but these should give you plenty to get you started.
NHE
Re: BG12
Thanks for the info guys
- gibbledygook
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Re: BG12
Hey L, I've asked my private quack to see if he can get this stuff cheaply as it's already licensed for other conditions, psoriasis, I think. Dr Kapoor seemed very enthusiastic about it since its side effect profile is good.
Will keep you posted.
Am going to see Dr Sclafani in July.
Will keep you posted.
Am going to see Dr Sclafani in July.
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
Re: BG12
Cool thanks gg. Hope all goes well with dr sclafani.
How is dr k? I am no longer a patient of his..weirdly i kinda miss the fella! Was with him 4 ten years
How is dr k? I am no longer a patient of his..weirdly i kinda miss the fella! Was with him 4 ten years
- gibbledygook
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Re: BG12
Hi,
Kapoor is well. He's always friendly and kind. He appears in one of the NHS magazines on disease modifying drugs. It's good to know they don't waste money on actors! Like in America.
I can't wait for Sclafani to investigate my renal vein as I strongly suspect this may have a severe blockage but we'll see.
Has your MS settled back down? I really hope so.
Kapoor is well. He's always friendly and kind. He appears in one of the NHS magazines on disease modifying drugs. It's good to know they don't waste money on actors! Like in America.
I can't wait for Sclafani to investigate my renal vein as I strongly suspect this may have a severe blockage but we'll see.
Has your MS settled back down? I really hope so.
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
Re: BG12
Ish...It has given some real issues cognitively:( I had a really bad cog relapse, lesions everywhere in frontal lobe but I am busy doing brain training exercises hoping to re-route and connect some new neurons!
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- CureOrBust
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Re: BG12
dimethyl fumarate and monomethyl fumarate
http://www.ipaustralia.com.au/applicant ... 010242064/
http://www.ipaustralia.com.au/applicant ... 010242064/
- stillfighting
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Re: BG12
Actually fumeric acid is a supplement and can be gotten at any online vitamin store. It's cheap too.. don't rush in I have read it is also useless.
I have seen where it will not do us any good to take. Something about the wrong (esters) I think.
It's just not the right compound.
Something like that, but close.
I have seen where it will not do us any good to take. Something about the wrong (esters) I think.
It's just not the right compound.
Something like that, but close.