Discovery of a treatment to block MS progression

[MSUK]

A drug that could halt the progression of MS may soon be developed thanks to a discovery by a team at the CHUM Research Centre and the University of Montreal........... Read more - http://www.ms-uk.org/emergingtherapies

[1eye]

My God, 50% of mice with EAE! I'll just race to the nearest stock broker and stock up! Except, wasn't Tysabri an adhesion molecule too? And didn't stopping immune cells from crossing the blood-brain-barrier allow deadly attacks of PML? Well, PML doesn't kill mice does it? So we know we're safe, don't we? Well, don't we?

Thank God for breakthroughs. I wouldn't last a day without 'em.

[EricDrake]

Well thats true that at first look they could look familiar but they target totally different things even if their main goal is quite similar.

Of course these current results mean nothing yet just that it has the potential like many ther therpaies had, we cant know if it will fail too but I think it is better to hope for the best and it is nice to see that there are more and more emerging study in progressive ms and lets hope that one of them will succeed.

[MSbro]

Of course these current results mean nothing yet just that it has the potential like many ther therpaies had, we cant know if it will fail too but I think it is better to hope for the best and it is nice to see that there are more and more emerging study in progressive ms and lets hope that one of them will succeed.

How many drugs that worked very well on EAE in mice have turned out to work on human MS? I think the answer is zero.
Yet the researchers continue to experiment with this EAE model and continually make announcements when they find "a breakthrough"! The more one reads about MS the more frustrating it becomes.

[EricDrake]

How many drugs that worked very well on EAE in mice have turned out to work on human MS? I think the answer is zero.
Yet the researchers continue to experiment with this EAE model and continually make announcements when they find "a breakthrough"! The more one reads about MS the more frustrating it becomes.

As I said we can just hope that this one is not going to fail, they are using this model because thats the best day have, however thats true that now they are able to test it on human OPC-s aswell thanks to a discovery in 2011 and in the article they also mention they tested it on human cells in vitro not jsut mouse. I know it means nothing and it has to be tested in real humans first before anything could be said but still there is a slight chance. I mean like 25 years ago we didnt have any kind of treatment for relapsing MS and now there are plenty of them which helps lots of people.

[MSbro]

I mean like 25 years ago we didnt have any kind of treatment for relapsing MS and now there are plenty of them which helps lots of people.

Although I am new to this board, I have spent a lot of time reading various threads. And there sure seems to be an awful lot of doubt about the benefit of any of these drugs for MS patients in the long run.

[EricDrake]

Although I am new to this board, I have spent a lot of time reading various threads. And there sure seems to be an awful lot of doubt about the benefit of any of these drugs for MS patients in the long run.

Yeah thats true, since they dont stop the progression in the end when it turns into spms they do not help, but I think it still means a lot that you have less lesions/inflammation during the rrms stage and that you enter spms with better conditions.

Of course these treatments are really strong and dangerous treatments, but they are continuously monitoring you if you have side effects (for example low white blood cell number in tecfidera)

But I agree that the safety profile of current drugs are not the best and we need safer ones for longterm use.

[lyndacarol]

And there sure seems to be an awful lot of doubt about the benefit of any of these drugs for MS patients in the long run.

My thoughts exactly.

[MSbro]

Of course these treatments are really strong and dangerous treatments, but they are continuously monitoring you if you have side effects (for example low white blood cell number in tecfidera)

Yet I've read posts by patients and relatives that they are given these drugs and don't hear from their MS doctor for months and months. So they could be suffering from nasty side effects for a long time and nothing gets done. Just doesn't seem right.