Insights into white matter could help MS recovery
Insights into white matter could help MS recovery
The cells that create myelin, a fatty material that insulates nerve fibres in the brain’s white matter, migrate into the developing brain by climbing and swinging on blood vessels, according to new research led by UC San Francisco scientists. ...Read more - http://www.ms-uk.org/MSnews
MS-UK - http://www.ms-uk.org/
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CureOrBust
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Re: Insights into white matter could help MS recovery
What I'm reading here is
1. "oligodendrocyte precursors"(OPC) start life/exist in the peripheral blood
2. They may OR may not cross the BBB
3. Once at the site (ie near neurons), they will automatically convert to mature oligodendrocyte, which mylinate the neurons
So, currently they can filter Stem Cells from blood (after they are forced to migrate from the marrow) and concentrate and expand the cells, so, would a treatment not be to extract and expand the OPC's from the MS patients blood, then inject their own expanded OPC cells directly into the CNS? Sounds like a treatment that would need to be repeated, and would no help create new neurons, but any fledgling neurons may not die premature due to not being protected by Myelin. It would also sound like a treatment that would be considerably less risky/toxic than the chemo involved in HSCT.
1. "oligodendrocyte precursors"(OPC) start life/exist in the peripheral blood
2. They may OR may not cross the BBB
3. Once at the site (ie near neurons), they will automatically convert to mature oligodendrocyte, which mylinate the neurons
So, currently they can filter Stem Cells from blood (after they are forced to migrate from the marrow) and concentrate and expand the cells, so, would a treatment not be to extract and expand the OPC's from the MS patients blood, then inject their own expanded OPC cells directly into the CNS? Sounds like a treatment that would need to be repeated, and would no help create new neurons, but any fledgling neurons may not die premature due to not being protected by Myelin. It would also sound like a treatment that would be considerably less risky/toxic than the chemo involved in HSCT.