MRZ Reaction as biomarker without oligoclonal bands

[frodo]

MS without oligoclonal bands is difficult to diagnosize. The MRZ reaction can help.

The intrathecal polyspecific antiviral immune response (Mrz reaction): A potential cerebrospinal fluid marker for multiple sclerosis diagnosis

Highlights

• The MRZ reaction has a very high specificity and positive predictive value for MS diagnosis
• The MRZ reaction is a useful diagnostic marker for routine laboratory OCB-negative MS patients
• The MRZ reaction seems to be part of the polyspecific intrathecal humoral immune response in MS
• The Vaccination status may impact the prevalence of the intrathecal reaction against viruses in MS and thus, the reliability of the test in clinical practice

https://www.sciencedirect.com/science/a ... 2818300687