reference intervals and clinical decision limits

Discuss herbal therapies, vitamins and minerals, etc. here
Post Reply
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

reference intervals and clinical decision limits

Post by jimmylegs »

Distinguishing reference intervals and clinical decision limits - A review by the IFCC Committee on Reference Intervals and Decision Limits (2018)
https://www.ncbi.nlm.nih.gov/pubmed/30047297

"Reference Intervals (RIs) and clinical decision limits (CDLs) are a vital part of the information supplied by laboratories to support the interpretation of numerical clinical pathology results. RIs describe the typical distribution of results seen in a healthy reference population while CDLs are associated with a significantly higher risk of adverse clinical outcomes or are diagnostic for the presence of a specific disease."

let's recall that these reference intervals describe the typical distribution of results seen in a *nominally* healthy reference population, which tends to include both sick and healthy people.

rather than emphasizing *this* is the point at which things are significantly worse, i like to use these the other way around. where's the interval with *lowest* risk of adverse outcomes, and how do i make sure my levels are okay according to that positive CDL. i'm interested in whether my levels (probably moreso in combination/collectively than individually, for that matter) can be considered diagnostic for the presence of health.
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
Post Reply

Return to “Natural Approach”