D3, Magnesium, Cognition

[jimmylegs]

interesting bit of zeroing in on the mag x d3 sweet spot:

Association of Vitamin D and Magnesium Status with Cognitive Function in Older Adults: Results from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2014 (FS05-03-19) (2019)
https://academic.oup.com/cdn/article/3/ ... 19/5517953

"...An inverse association of higher serum 25(OH)D with cognitive function was observed primarily among participants with a daily total magnesium intake of <254 mg... or ≥375 mg."

recalling

Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial (2018)
https://academic.oup.com/ajcn/article/1 ... 49/5239886

"...Magnesium supplementation increased the 25(OH)D3 concentration when baseline 25(OH)D concentrations were close to 30 ng/mL, but decreased it when baseline 25(OH)D was higher (from ∼30 to 50 ng/mL). "

[NHE]

interesting bit of zeroing in on the mag x d3 sweet spot:

Association of Vitamin D and Magnesium Status with Cognitive Function in Older Adults: Results from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2014 (FS05-03-19) (2019)

"...An inverse association of higher serum 25(OH)D with cognitive function was observed primarily among participants with a daily total magnesium intake of <254 mg... or ≥375 mg."

That's interesting. The abstract appears to state that higher Mg²⁺ and higher D3 status both correlated with higher cognition test scores.

Association of magnesium intake and vitamin D status with cognitive function in older adults: an analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014.
Eur J Nutr. 2020 May 9.

PURPOSE: Reduced cognitive function associated with aging has gained increasing attention as the US population ages. Magnesium plays a critical role in vitamin D biosynthesis and metabolism; and deficiencies in magnesium and vitamin D show associations with poor cognition. However, no study has examined their interaction. This study aimed to evaluate the associations of magnesium intake and serum 25-hydroxyvitamin D (25(OH)D) concentrations, indicating vitamin D status, with cognition, and interaction between these nutrients in older adults.

METHODS: Based on the National Health and Nutrition Survey (NHANES) 2011-2014, the study included 2466 participants aged ≥ 60 years who completed the Digit Symbol Substitution Test (DSST) and had data available on serum 25(OH)D and magnesium intake. Cognitive impairment was defined as a DSST score lower than the lowest quartile. Serum 25(OH)D concentrations were measured by HPLC-tandem mass spectrometry.

RESULTS: Higher total magnesium intake was independently associated with higher DSST scores (highest quartile vs lowest: β = 4.34, 95% CI 1.14-7.54). The association of total magnesium intake with high DSST score was primarily observed among women, non-Hispanic whites, physically active participants and those with sufficient vitamin D status, although the interactions were not significant. The odds of cognitive impairment was reduced with increasing intake of total magnesium (p trend < 0.01) and higher level of serum 25(OH)D (p trend = 0.05).

CONCLUSIONS: Findings suggest that high magnesium intake alone may improve cognitive function in older adults, and the association may be stronger among subjects with sufficient vitamin D status. Further studies are needed to confirm these findings.

[jimmylegs]

interesting indeed. i can't get into comparing the authors' 2019 and 2020 dtls just now. another time!