Genome Wide Associated Study: Genes involved in lesion locations

[frodo]

The authors propose that some existing drugs could be repurposed to target each the genetic pathway.

An integrative study of genetic variants with brain tissue expression identifies viral etiology and potential drug targets of multiple sclerosis

https://www.sciencedirect.com/science/a ... pKP-Wqh5A0

Highlights

• Cross Dataset Evaluation was developed to investigate NAWM and the largest MS GWAS.
• Rubidomycin and zafirlukast are drugs suggested to be repurposed for MS treatment.
• MAPK and JAK2/STAT3 pathways are identified as major potential drug targets in MS.
• Prioritized genes for MS risk: CDK4, IFITM3, MAPK1, MAPK3, METTL12B and PIK3R2
• Conjectural mechanisms of viral involvement in MS etiology are presented.