MSRV Retrovirus, phase 2

A board to discuss future MS therapies in early stage (Phase I or II) trials.
Fred1208
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Re: MSRV Retrovirus, phase 2

Post by Fred1208 »

New videos !!

Don't forget to subscribe !!
Fred1208
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Location: Yvelines, France
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Re: MSRV Retrovirus, phase 2

Post by Fred1208 »

Fred1208
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Posts: 62
Joined: Sat Nov 07, 2009 3:00 pm
Location: Yvelines, France
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Re: MSRV Retrovirus, phase 2

Post by Fred1208 »

Stay tuned !!
The new revolution is coming regarding yhe understanding of auto-immune deseases !!

For the first time, MS process could be STOPPED.

http://www.geneuro.com/data/documents/2 ... ion-MP.pdf
Fred1208
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Location: Yvelines, France
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Re: MSRV Retrovirus, phase 2

Post by Fred1208 »

Fred1208
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Posts: 62
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Location: Yvelines, France
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Re: MSRV Retrovirus, phase 2

Post by Fred1208 »

Genuero Presentation: Defeating neurodegeneration through HERVs
April 2021

http://www.geneuro.com/data/documents/2 ... tation.pdf
Fred1208
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Re: MSRV Retrovirus, phase 2

Post by Fred1208 »

Tommrrow 6 PM swiss time

webinar, should be in english, subscriibe here :

https://register.gotowebinar.com/regist ... 5759504651
NHE
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Re: MSRV Retrovirus, phase 2

Post by NHE »

Here's an interesting write-up on endogenous retroviruses.

https://encyclopedia.thefreedictionary. ... retrovirus
TinaMeyer
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Re: MSRV Retrovirus, phase 2

Post by TinaMeyer »

Hello, here is an update concerning the extension study of the Protect-MS study with temelimab, dd 09/21/2021. This extension study allows the patients, who already have had 12 infusions, to continue the treatment with temelimab. The results of the Protect-MS study are still expected Q1 2022.

"GeNeuro announces that a first patient having finished the ProTEct-MS study at the Karolinska Institutet’s Academic Specialist Center has entered the study extension...."

Please read the full statement on the link below :

http://www.geneuro.com/en/technologies/rationale
TinaMeyer
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Re: MSRV Retrovirus, phase 2

Post by TinaMeyer »

Sorry, that's the wrong link. The good one is:

http://www.geneuro.com/data/news/GeNeur ... nt-ENG.pdf
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frodo
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Re: MSRV Retrovirus, phase 2

Post by frodo »

First patient has just finished his study

https://www.businesswire.com/news/home/ ... -Extension
Fred3582
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Re: MSRV Retrovirus, phase 2

Post by Fred3582 »

Hello, the PRoTEct-MS study with temelimab is completed and the top-line results to be announced in march 2022 :-D :

https://www.businesswire.com/news/home/ ... er-31-2021
Fred3582
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Re: MSRV Retrovirus, phase 2/RESULTS

Post by Fred3582 »

Hello, good news :-D,

The results of the phase 2 trial with temelimab announced today:

"ProTEct-MS Phase 2 Trial Confirms Safety of Higher Doses of Temelimab and Synergistic Potential to Address Neurodegeneration on Top of Anti-inflammatory Treatment in Multiple Sclerosis..."

More here:

http://www.geneuro.com/data/news/GeNeur ... 1-2022.pdf

:-D
Fred3582
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Re: MSRV Retrovirus, phase 2

Post by Fred3582 »

Hello,

Here's a link to the presentation of these top-line results:

http://www.geneuro.ch/data/documents/GN ... 22-ENG.pdf

:-D
Fred3582
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Re: MSRV Retrovirus, phase 2

Post by Fred3582 »

Hello,

Watch the comments of these results hereby, if you are interested :smile:

Fred3582
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Re: MSRV Retrovirus, phase 2

Post by Fred3582 »

Hi,

These results have been presented at the ECTRIMS 2022 congress (10/27) in Amsterdam by dr Frederik Piehl, from the Karolinska Institutet in Sweden.

"GeNeuro’s ProTEct-MS Phase 2 Trial Data, Presented at the ECTRIMS 2022 Congress in Amsterdam, Confirms Synergistic Neuroprotective Potential of Temelimab in MS

Excellent safety profile and tolerability of higher doses of temelimab

Synergistic potential to treat neurodegeneration in addition to high-efficacy anti-inflammatory therapy in multiple sclerosis

Exploratory CSF biomarkers confirm MRI efficacy observations (...)"

From this link :

https://www.businesswire.com/news/home/ ... imab-in-MS

By the way temelimab is also been currently tested in a P2 clinical trial on the Post-Covid condition, a 6 months study:

https://clinicaltrials.gov/ct2/show/NCT ... w=2&rank=1

The longhaulers enroled must have the pHERV-w protein in the blood. --> In MS, this protein is in the brain and supposed to be responsible of the neurodegeneration.

Fingers crossed.
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