Tropospheric ozone
Re: Tropospheric ozone
O3
2023 Sep 24
College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China
Circadian rhythm disturbances involved in ozone-induced glucose metabolism disorder in mouse liver
https://pubmed.ncbi.nlm.nih.gov/37742977/
..The findings emphasized the interaction between adverse outcomes of circadian rhythms and glycometabolism following O3 exposure.
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MS
23 April 2019
Multiple Sclerosis and Circadian Clock: Possible Link Discovered for the Onset of the Disease
https://www.uniroma1.it/en/notizia/mult ... et-disease
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7 January 2022
Vitamin D Deficiency Is Associated with Glycometabolic Changes in Nondiabetic Patients with Arterial Hypertension https://www.mdpi.com/2072-6643/14/2/311
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October 7, 2020
High Blood Pressure is Common in MS, Says New Study: Learn How to Stay Well (:/)
https://www.nationalmssociety.org/About ... s-New-Stud
2023 Sep 24
College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China
Circadian rhythm disturbances involved in ozone-induced glucose metabolism disorder in mouse liver
https://pubmed.ncbi.nlm.nih.gov/37742977/
..The findings emphasized the interaction between adverse outcomes of circadian rhythms and glycometabolism following O3 exposure.
------------------------------------------
MS
23 April 2019
Multiple Sclerosis and Circadian Clock: Possible Link Discovered for the Onset of the Disease
https://www.uniroma1.it/en/notizia/mult ... et-disease
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7 January 2022
Vitamin D Deficiency Is Associated with Glycometabolic Changes in Nondiabetic Patients with Arterial Hypertension https://www.mdpi.com/2072-6643/14/2/311
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October 7, 2020
High Blood Pressure is Common in MS, Says New Study: Learn How to Stay Well (:/)
https://www.nationalmssociety.org/About ... s-New-Stud
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Nov 3 Center for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and Gynecology, Maternal Hospital of Nankai University, Tianjin Key Laboratory of Human Development and Reproductive Regulation, China
Association of exposure to ozone and fine particulate matter with ovarian reserve among women with infertility
https://pubmed.ncbi.nlm.nih.gov/37926414/
-- Further analyses indicated that the reduced ovarian reserve measured by AMH level was only significantly associated with PM2.5 exposure during follicle development from the primary to preantral follicle stage (Period 2) but was significantly associated with O3 exposure during Periods 1, 2, and 3. These observations were robust in the dual-pollutant model considering co-exposure to PM2.5 and O3. The results indicated an inverse association between ovarian reserve and ambient O3 exposure and suggested distinct susceptibility windows for O3 and PM2.5 for reduced ovarian reserve. These findings highlight the need to control ambient air pollution to reduce invisible risks to women's fertility, especially at high O3 concentrations.
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MS
2023 Apr 5
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy
Ovarian reserve in patients with multiple sclerosis: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/37017322/
Conclusion: A significant difference in AFC, estradiol and LH levels was observed, but not for AMH levels
2023 Nov 3 Center for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and Gynecology, Maternal Hospital of Nankai University, Tianjin Key Laboratory of Human Development and Reproductive Regulation, China
Association of exposure to ozone and fine particulate matter with ovarian reserve among women with infertility
https://pubmed.ncbi.nlm.nih.gov/37926414/
-- Further analyses indicated that the reduced ovarian reserve measured by AMH level was only significantly associated with PM2.5 exposure during follicle development from the primary to preantral follicle stage (Period 2) but was significantly associated with O3 exposure during Periods 1, 2, and 3. These observations were robust in the dual-pollutant model considering co-exposure to PM2.5 and O3. The results indicated an inverse association between ovarian reserve and ambient O3 exposure and suggested distinct susceptibility windows for O3 and PM2.5 for reduced ovarian reserve. These findings highlight the need to control ambient air pollution to reduce invisible risks to women's fertility, especially at high O3 concentrations.
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MS
2023 Apr 5
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy
Ovarian reserve in patients with multiple sclerosis: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/37017322/
Conclusion: A significant difference in AFC, estradiol and LH levels was observed, but not for AMH levels
https://www.eboro.cz
Re: Tropospheric ozone
Petr75 wrote: ↑Thu Sep 14, 2023 10:33 pm O3
2020 Jul
Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, Member DZL, German Center for Lung Research, Munich, Germany
Depression and anxiety with exposure to ozone and particulate matter: An epidemiological claims data analysis
https://pubmed.ncbi.nlm.nih.gov/32442925/
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MS
2023 Aug 29
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
The prevalence of major depression and generalized anxiety disorder in patients with multiple sclerosis in Saudi Arabia: a cross-sectional multicentered study
https://pubmed.ncbi.nlm.nih.gov/37706033/
2023 Nov 10
HEOA Group, School of Public Health, Chengdu University of Traditional Chinese Medicine, China
Short-term ambient ozone exposure increases the risk of hospitalization with depression: a multi-city time-stratified case-crossover study
https://pubmed.ncbi.nlm.nih.gov/37950397/
Conclusions:
Short-term changes to O3 exposure may increase the risk of depression related hospitalizations, especially on warm days.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Nov 3
Neurological and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, CPHEA/ORD, US Environmental Protection Agency, Research Triangle Park, USA
Influence of Mild Chronic Stress and Social Isolation on Acute Ozone-Induced Alterations in Stress Biomarkers and Brain-Region-Specific Gene Expression in Male Wistar-Kyoto Rats
https://pubmed.ncbi.nlm.nih.gov/38001817/
Individuals with psychosocial stress often experience an exaggerated response to air pollutants. Ozone (O3) exposure has been associated with the activation of the neuroendocrine stress-response system. We hypothesized that preexistent mild chronic stress plus social isolation (CS), or social isolation (SI) alone, would exacerbate the acute effects of O3 exposure on the circulating adrenal-derived stress hormones, and the expression of the genes regulating glucocorticoid stress signaling .....
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MS
Stress and multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193283/
Free full text.
Sphingolipids in multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987401/
Free full text.
2023 Nov 3
Neurological and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, CPHEA/ORD, US Environmental Protection Agency, Research Triangle Park, USA
Influence of Mild Chronic Stress and Social Isolation on Acute Ozone-Induced Alterations in Stress Biomarkers and Brain-Region-Specific Gene Expression in Male Wistar-Kyoto Rats
https://pubmed.ncbi.nlm.nih.gov/38001817/
Individuals with psychosocial stress often experience an exaggerated response to air pollutants. Ozone (O3) exposure has been associated with the activation of the neuroendocrine stress-response system. We hypothesized that preexistent mild chronic stress plus social isolation (CS), or social isolation (SI) alone, would exacerbate the acute effects of O3 exposure on the circulating adrenal-derived stress hormones, and the expression of the genes regulating glucocorticoid stress signaling .....
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MS
Stress and multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193283/
Free full text.
Sphingolipids in multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987401/
Free full text.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Jul 13
College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, China
Effects of ozone exposure on lipid metabolism in Huh-7 human hepatoma cells
https://pubmed.ncbi.nlm.nih.gov/37521985/
..Overall, O3 exposure induces an increase in intracellular oxidative stress and disrupts the normal metabolism of lipids in hepatocytes, leading to intracellular lipid accumulation.
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MS
2021 Jul
New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303889/
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08 July 2023
Autoimmune liver disease and multiple sclerosis: state of the art and future perspectives
https://link.springer.com/article/10.10 ... 23-01128-8
2023 Jul 13
College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, China
Effects of ozone exposure on lipid metabolism in Huh-7 human hepatoma cells
https://pubmed.ncbi.nlm.nih.gov/37521985/
..Overall, O3 exposure induces an increase in intracellular oxidative stress and disrupts the normal metabolism of lipids in hepatocytes, leading to intracellular lipid accumulation.
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MS
2021 Jul
New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303889/
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08 July 2023
Autoimmune liver disease and multiple sclerosis: state of the art and future perspectives
https://link.springer.com/article/10.10 ... 23-01128-8
Last edited by Petr75 on Sat Dec 02, 2023 2:12 pm, edited 2 times in total.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Nov 29
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
Short-term exposure to ozone may trigger the onset of Kawasaki disease: An individual-level, case-crossover study in East China
https://pubmed.ncbi.nlm.nih.gov/38040257/
Abstract
Kawasaki disease (KD) is an acute, systemic vasculitis that primarily affects children aged under the age of 5. While environmental factors have been linked to the development of KD, the specific role of ozone (O3) pollution in triggering the disease onset remains uncertain. This study aimed to examine the associations between short-term O3 exposure and KD onset in children. ....Our findings revealed a significant association of O3 exposure with KD onset on the day of onset(lag 0 day) ...
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2020 Aug 9
Danish Cancer Society Research Center, Copenhagen, Denmark
Kawasaki disease, autoimmune disorders, and cancer: a register-based study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415012/
...Studies indicate that KD is triggered by an abnormal autoimmune response caused by an infection [7–9], but no definitive agent has been found. The potent anti-inflammatory effect of immunoglobulin treatment in the early stages of the disease indicates that autoimmunity or auto-inflammation could be essential in KD [10, 11], which one of these factors that are the most important has not been clarified [10]. However, this observation could suggest that KD might be a severe autoimmune manifestation in a child predisposed to other autoimmune diseases later in life. Yet, no long-term follow-up studies have yet investigated this theory.
2023 Nov 29
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
Short-term exposure to ozone may trigger the onset of Kawasaki disease: An individual-level, case-crossover study in East China
https://pubmed.ncbi.nlm.nih.gov/38040257/
Abstract
Kawasaki disease (KD) is an acute, systemic vasculitis that primarily affects children aged under the age of 5. While environmental factors have been linked to the development of KD, the specific role of ozone (O3) pollution in triggering the disease onset remains uncertain. This study aimed to examine the associations between short-term O3 exposure and KD onset in children. ....Our findings revealed a significant association of O3 exposure with KD onset on the day of onset(lag 0 day) ...
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2020 Aug 9
Danish Cancer Society Research Center, Copenhagen, Denmark
Kawasaki disease, autoimmune disorders, and cancer: a register-based study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415012/
...Studies indicate that KD is triggered by an abnormal autoimmune response caused by an infection [7–9], but no definitive agent has been found. The potent anti-inflammatory effect of immunoglobulin treatment in the early stages of the disease indicates that autoimmunity or auto-inflammation could be essential in KD [10, 11], which one of these factors that are the most important has not been clarified [10]. However, this observation could suggest that KD might be a severe autoimmune manifestation in a child predisposed to other autoimmune diseases later in life. Yet, no long-term follow-up studies have yet investigated this theory.
https://www.eboro.cz
Re: Tropospheric ozone
O3
October 7, 2018
The Impact of Chronic Ozone and Particulate Air Pollution on Mortality in Patients With Sepsis Across the United States
https://journals.sagepub.com/doi/abs/10 ... lCode=jica
Conclusion:
Exposure to increased levels of ozone but not particulate air pollution was associated with higher risk of mortality in patients with sepsis. This association was strongest in patients with pneumonia but persisted in all sources of sepsis. Further work is needed to understand the relationship between ambient ozone air pollution and sepsis
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MS
2023 Dec 5
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/38053214/
....In the real-world observational study, adjusting for multiple confounders, rheumatoid arthritis (OR = 1.34, 95% CI = 1.11-1.64, p = 0.003) and multiple sclerosis (OR = 1.31, 95% CI = 1.03-1.68, p = 0.02) were associated with a higher risk of sepsis
October 7, 2018
The Impact of Chronic Ozone and Particulate Air Pollution on Mortality in Patients With Sepsis Across the United States
https://journals.sagepub.com/doi/abs/10 ... lCode=jica
Conclusion:
Exposure to increased levels of ozone but not particulate air pollution was associated with higher risk of mortality in patients with sepsis. This association was strongest in patients with pneumonia but persisted in all sources of sepsis. Further work is needed to understand the relationship between ambient ozone air pollution and sepsis
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MS
2023 Dec 5
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/38053214/
....In the real-world observational study, adjusting for multiple confounders, rheumatoid arthritis (OR = 1.34, 95% CI = 1.11-1.64, p = 0.003) and multiple sclerosis (OR = 1.31, 95% CI = 1.03-1.68, p = 0.02) were associated with a higher risk of sepsis
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Dec 13
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China
Assessing the short-term effects of PM2.5 and O3 on cardiovascular mortality using high-resolution exposure: a time-stratified case cross-over study in Southwestern China
https://pubmed.ncbi.nlm.nih.gov/38087153/
Air pollution is a major risk factor of cardiovascular disease ...
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MS
May 4, 2020
Evaluating the Risk of Macrovascular Events and Mortality Among People With Multiple Sclerosis in England
https://jamanetwork.com/journals/jamane ... le/2765472
Conclusions
This study suggests that MS is associated with an increased risk of cardiovascular and cerebrovascular disease that is not completely accounted for by traditional vascular risk factors. Given the adverse effects of these comorbidities on outcomes in patients with MS, further investigation is needed.
2023 Dec 13
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China
Assessing the short-term effects of PM2.5 and O3 on cardiovascular mortality using high-resolution exposure: a time-stratified case cross-over study in Southwestern China
https://pubmed.ncbi.nlm.nih.gov/38087153/
Air pollution is a major risk factor of cardiovascular disease ...
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MS
May 4, 2020
Evaluating the Risk of Macrovascular Events and Mortality Among People With Multiple Sclerosis in England
https://jamanetwork.com/journals/jamane ... le/2765472
Conclusions
This study suggests that MS is associated with an increased risk of cardiovascular and cerebrovascular disease that is not completely accounted for by traditional vascular risk factors. Given the adverse effects of these comorbidities on outcomes in patients with MS, further investigation is needed.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2008 Oct
Department of Rheumatology, St. Luc University Hospital, Brussels, Belgium
Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer
https://pubmed.ncbi.nlm.nih.gov/18628525/
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Published: 02 November 2021
nature.com
Air pollutants are negatively associated with vitamin D-synthesizing UVB radiation intensity on the ground
https://www.nature.com/articles/s41598-021-00980-6
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MS
2023 Dec 17
Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic
Molecular Regulation of the CNS by Vitamin D
https://pubmed.ncbi.nlm.nih.gov/38116771/
Abstract
Vitamin D is a lipid-soluble vitamin that can be found in some foods. It is also produced endogenously (in the presence of ultraviolet light), transported through the blood to the targets organs and this is the reason to consider vitamin D as a hormone. It is known that vitamin D has genomic and non-genomic effects. This review is focused mainly on the vitamin D receptors, the importance of vitamin D as a neuromodulator, the role of vitamin D in the pathophysiology of devastating neurological disorders such as Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease and the benefit of vitamin D and its derivates in alleviating these disorders.
2008 Oct
Department of Rheumatology, St. Luc University Hospital, Brussels, Belgium
Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer
https://pubmed.ncbi.nlm.nih.gov/18628525/
¨¨¨¨¨¨¨¨¨¨¨¨¨¨¨¨¨
Published: 02 November 2021
nature.com
Air pollutants are negatively associated with vitamin D-synthesizing UVB radiation intensity on the ground
https://www.nature.com/articles/s41598-021-00980-6
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MS
2023 Dec 17
Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic
Molecular Regulation of the CNS by Vitamin D
https://pubmed.ncbi.nlm.nih.gov/38116771/
Abstract
Vitamin D is a lipid-soluble vitamin that can be found in some foods. It is also produced endogenously (in the presence of ultraviolet light), transported through the blood to the targets organs and this is the reason to consider vitamin D as a hormone. It is known that vitamin D has genomic and non-genomic effects. This review is focused mainly on the vitamin D receptors, the importance of vitamin D as a neuromodulator, the role of vitamin D in the pathophysiology of devastating neurological disorders such as Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease and the benefit of vitamin D and its derivates in alleviating these disorders.
https://www.eboro.cz
Re: Tropospheric ozone
2023 Dec 22
Department of Outpatient, Taihe Hospital, Hubei University of Medicine, China
Long-term ozone exposure and all-cause mortality: Cohort evidence in China and global heterogeneity by region
https://pubmed.ncbi.nlm.nih.gov/38141337/
..Conclusions: This study provided national evidence that high O3 exposure may curtail long-term survival of Chinese general population. Great between-region heterogeneity of pooled O3-mortality was identified across North America, Europe, and Asia.
Free full text.
Department of Outpatient, Taihe Hospital, Hubei University of Medicine, China
Long-term ozone exposure and all-cause mortality: Cohort evidence in China and global heterogeneity by region
https://pubmed.ncbi.nlm.nih.gov/38141337/
..Conclusions: This study provided national evidence that high O3 exposure may curtail long-term survival of Chinese general population. Great between-region heterogeneity of pooled O3-mortality was identified across North America, Europe, and Asia.
Free full text.
https://www.eboro.cz
Re: Tropospheric ozone
2024 Jan 23Petr75 wrote: ↑Mon Jan 24, 2022 12:00 pm 18 November 2021
School of Public Health, Capital Medical University, China
The association between ozone and ischemic stroke morbidity among patients with type 2 diabetes in Beijing, China
https://www.sciencedirect.com/science/a ... 9721068091
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2022 Jan 6
Nanshan School, Guangzhou Medical University, China
Myocardial infarction and stroke risks in multiple sclerosis patients: A two-sample Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/35066269/
Abstract
Observational studies indicated multiple sclerosis (MS) patients may have a higher risk of myocardial infarction (MI) and stroke than the general population, whereas the previously reported findings were inconsistent. Using two-sample Mendelian randomization (MR) analysis with genetic data from large-scale genome-wide association studies (International Multiple Sclerosis Genetics Consortium containing 14,498 MS cases, Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics consortium containing 43,676 MI cases and 40,585 stroke cases), we found that MS was causally associated with an increased risk of MI (OR = 1.03; 95%CI 1.00-1.06; P = 0.0243), directionally consistent in the weighted median, MR-Egger, and the MR-PRESSO methods. No causal association between MS and stroke was observed (OR = 1.01; 95%CI 0.99-1.04; P = 0.2974). Therefore, timelier and more effective measures should be conducted among MS patients to decrease the burden of both diseases.
Association of multiple sclerosis with stroke: A comprehensive review
https://pubmed.ncbi.nlm.nih.gov/38264155/
Conclusion: In conclusion, this review underscores the critical need for a thorough understanding of the complex relationship between MS and stroke. The identified risk factors and the influence of MS DMTs on stroke risk necessitate further investigation to inform evidence-based preventive and therapeutic strategies. Bridging the existing information gaps through prospective multicenter studies is imperative for a comprehensive understanding of this association. The development of targeted diagnostic and therapeutic approaches for acute stroke risk in MS patients is paramount to mitigate the impact of these debilitating conditions. Ultimately, this review serves as a foundation for future efforts to enhance preventative measures and therapeutic interventions, thereby improving the overall quality of life for individuals with MS susceptible to strokes.
https://www.eboro.cz
Re: Tropospheric ozone
Petr75 wrote: ↑Fri Jan 06, 2023 10:42 am 2023 Jan 1
Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland
Effect of ozone exposure on the foraging behaviour of Bombus terrestris
https://pubmed.ncbi.nlm.nih.gov/36334775/
Abstract
Tropospheric ozone (O3) mixing ratios have increased substantially since preindustrial times and high O3 peaks are increasingly common. Plant-pollinator interactions are central to natural ecosystem functioning and food production systems but could be negatively affected by unfavourable environmental conditions such as elevated O3. Ecosystem functioning is threatened by O3, which can degrade floral volatile organic compounds (VOCs) used by pollinators as olfactory cues during foraging. It can also exert oxidative stress on VOC-emitting plants and receiving organisms, potentially disturbing the sending and receiving of VOC signals....
2024 Feb 12
CEFE, Université de Montpellier, CNRS, EPHE, France
Ozone alters the chemical signal required for plant - insect pollination: The case of the Mediterranean fig tree and its specific pollinator
https://pubmed.ncbi.nlm.nih.gov/38354792/
Tropospheric ozone (O3) is likely to affect the chemical signal emitted by flowers to attract their pollinators through its effects on the emission of volatile organic compounds (VOCs) and its high reactivity with these compounds in the atmosphere....
https://www.eboro.cz