Epigenetic

[Petr75]

2022 Jan 19
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Iran
An Updated Review of Epigenetic-Related Mechanisms and Their Contribution to Multiple Sclerosis Disease
https://pubmed.ncbi.nlm.nih.gov/35043771/

Abstract

Multiple Sclerosis (MS) is a multifactorial, neurodegenerative and inflammatory demyelination disease with incomplete remyelination in the CNS. It would be more informative to reveal the underlying molecular mechanisms of MS. Molecular mechanisms involving epigenetic changes play pivotal role in this disease. Epigenetic changes impact on gene expression without altering the underlying DNA sequence. The main epigenetic modifications which play a key role in the regulation of gene expression principally include DNA methylation, histone modifications, and microRNA-associated post-transcriptional gene silencing. In this review, we summarize the dynamics of epigenetic changes and their relation to environmental risk factors in MS pathogenesis. Studies suggest that epigenetic changes have a role in the development of MS and environmental risk factors, such as vitamin D, smoking, and Epstein-Barr virus infection seem to influence the development and susceptibility to MS. Investigating epigenetic and environmental factors can provide new opportunities for the molecular basis of the diseases which shows complicated pathogenesis. Epigenetic research has the potential to complete our understanding of MS initiation and progression. Increasing our knowledge about the molecular mechanisms in MS sheds light on new insights of potential MS treatments. However, there is a need for in vivo evaluation of the role of epigenetic factors in MS therapy. It would be more valuable to indicate the role of various epigenetic factors in MS.

[Petr75]

2024 May 29
Department of Medicine and Aging Sciences, G. D'Annunzio University of Chieti-Pescara, Italy
Unraveling the Epigenetic Landscape: Insights into Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/38928553/

Abstract

Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) are examples of neurodegenerative movement disorders (NMDs), which are defined by a gradual loss of motor function that is frequently accompanied by cognitive decline. Although genetic abnormalities have long been acknowledged as significant factors, new research indicates that epigenetic alterations are crucial for the initiation and development of disease.