Smouldering MS and metabolism

A forum to discuss research on the origins of MS and its development.
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frodo
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Smouldering MS and metabolism

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Topographical Mapping of Metabolic Abnormalities in Multiple Sclerosis

https://www.sciencedirect.com/science/a ... 192500045X

Conclusion

In conclusion, we utilized high-resolution echo-less 3D-MRSI at 7T to investigate the topography of metabolic changes in a large brain volume of MS patients. Our findings revealed distinct patterns of metabolic alterations outside lesional pathology, with widespread NAA/tCr reduction, especially in motor, sensory, and cognitive regions, and elevated mI/tCr levels concentrated around the lateral ventricles.

Metabolic ratios involving NAA correlated with disability scores, thereby highlighting the impact of neuronal damage on disease progression. Further large-scale longitudinal studies are needed to validate the potential of 3D-MRSI for enhanced monitoring of disease activity, progression, and treatment efficacy.
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