Hello and Help Please...

[cjwithms]

Diagnosed with MS in 2006 after an attack that left me not walking, I was put on steriods for a week and got back up but not without the help of a cane. I started Avonex in early 2007, but after having mini flare ups after each shot and then starting to not walk well again with a cane went on Tysabri in June of 2007.

Tysabri worked great, every month when I was due for the infusion I would start to loose my ability to walk and after treatment and with my cane, I was living life...However, after 18 treatments, I was diagnosed with Hodgkins Disease - Lymphoma and went through Cancer treatment and radiation for most of the year in 2009 and have been in remission ( I see my onocologist next week, so hopefully, I am still good).

Question/Help - I had been doing excellent since the cancer drugs, even walking better and sometimes with out the cane and then...the attack came about a month ago - pretty big and bad - lost mobility and eyes started going so back on steriods I went and now my doctor wants me to go back on a "drug" - like Avonex, Copaxone, etc.... and I don't know what to do. I could just try and wait it out and see if I can live on steriod infusions, but know that the delay may cause damage that can not be fixed ( I still have some eye issues since the most recent attack)

Any recommendations? Anyone else diagnosed withh Lymphoma while on Tysabri?

Also, as an FYI - the Tysari/Biogen people never followed up on my case with the FDA...I still have their paperwork that was given to me by my doctor that needed my approval. I called them to discuss what they needed and they never followed up...guess they didn't want to know...

[jimmylegs]

see if you can get your hands on the full text of this article:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781584/
Mediators Inflamm. 2004 December; 13(5-6): 381–383.

Lipid peroxidation and protein oxidation in patients affected by Hodgkin's lymphoma.
Abstract
A dysregulation of the redox homoeostasis has been reported in various neoplastic disorders. Malondialdehyde/4-hydroxy-2,3-nonenal (MDA/HNE) and protein carbonyl groups represent in vivo indexes of lipid peroxidation and protein oxidation, respectively, suitable to investigate radical-mediated physio-pathological conditions. We evaluated MDA/HNE and protein carbonyl groups in sera of untreated Hodgkin's lymphoma (HL) patients in advanced disease stages, in order to quantify the oxidative stress. HL patients displayed significantly higher levels of both MDA/HNE and protein carbonyl groups as compared with healthy controls. This is the first evidence that a strong increase in HL is one of the most common haematological malignancies, representing approximately 30% of all lymphomas in the circulating protein carbonyl content in HL. These findings may contribute to a better definition of the redox homoeostasis dysregulation in HL.

...high MDA concentration has been shown to be associated with a dysregulation of antioxidant system. (i.e. low levels of selenium, zinc and glutathione...

i can not get more than that without better access.
if you are not on any kind of nutrition regimen for your ms, consider reading up on the info to be found in my signature links below.
any questions, feel free to ask.
HTH!