Experiences Log: Dr. Mark Freedman
- 1eye
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Regardless of his bedside manner, it would be good to refrain from ad-hominem attacks and libelous remarks. This is a semi-anonymous forum, and while I have my personal doubts about certain posters, I think everyone speaking or writing in public, identified as themselves, deserves to be answered in public with identified debaters who are willing to own up to their statements.
JMHO
BTW I have noted some attention has been given lately to vascular concerns in the 'MS' literature, even if it is sometimes only to give them short shrift.
There is one paper about t-cells not being peri-vascular. I have seen a video of t-cells which have been made fluorescent and filmed travelling along a microscopic blood vessel. If this technique could be used it might shed some light on what they do in the brain when blood is slow vs. normal. Also, some work needs to be done on the ubiquitous EAE model, to see if there is hypoxia and slowed perfusion in sick mice too.
JMHO
BTW I have noted some attention has been given lately to vascular concerns in the 'MS' literature, even if it is sometimes only to give them short shrift.
There is one paper about t-cells not being peri-vascular. I have seen a video of t-cells which have been made fluorescent and filmed travelling along a microscopic blood vessel. If this technique could be used it might shed some light on what they do in the brain when blood is slow vs. normal. Also, some work needs to be done on the ubiquitous EAE model, to see if there is hypoxia and slowed perfusion in sick mice too.
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Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
Oh my goodness, yes, that is another way to take a crack at it. If MS causes slowed perfusion (because of lesions or inflammation or "unknown causes"), EAE ought to also cause slow perfusion. If it's the other way around (another condition *coughccsvi* causes the slowed perfusion) then EAE would not cause the slowed perfusion. It seems simple to me, am I missing something?1eye wrote:Also, some work needs to be done on the ubiquitous EAE model, to see if there is hypoxia and slowed perfusion in sick mice too.
Although I still like Dr. Zamboni's response of "I am not a mouse doctor" or whatever his precise words were, last fall.

And I am glad that our IRs are people doctors and willing to treat while this is all getting sorted out.
"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition
nope ;)Cece wrote: It seems simple to me, am I missing something?
...two calls to me in two days sharing information of two more treated in Poland with outstanding and immediate results. A good friend's aunt and the mother of my nephew's friend...neither participate on TiMS or facebook.. how many others???.. lots of good people sticking their necks out..

http://www.thisisms.com/ftopicp-145.html#145
Mon Jan 05, 2004 9:46 pm Post subject: Rules of the Board
Mon Jan 05, 2004 9:46 pm Post subject: Rules of the Board
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- 1eye
- Family Elder
- Posts: 3780
- Joined: Wed Mar 17, 2010 3:00 pm
- Location: Kanata, Ontario, Canada
- Contact:
can't get over how funny your avatar is! Where can I get one?PCakes wrote:nope ;)Cece wrote: It seems simple to me, am I missing something?
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This unit of entertainment not brought to you by FREMULON.
Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
success!.. was meant to inspire a smile1eye wrote:can't get over how funny your avatar is! Where can I get one?PCakes wrote:nope ;)Cece wrote: It seems simple to me, am I missing something?
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