Remyelination: new research from Karolinska Institute

[1eye]

Clemastine trials: They don't want me anyway because in 2009, probably a delayed reaction to mitoxantrone from 2005, I had a wee heart attack. During that mitoxantrone course I was unilaterally taken off copaxone, which almost immediately after that was found to be synergistic with mitoxantrone. But did they re-instate me? No. Did I ask? Yes.

[cheerleader]

Wanted to add some more research on plasticity and remyelination in the human, not mouse, brain
and encourage pwMS to do all they can.
The human brain can reorganize and remyelinate.

Increasingly sophisticated brain imaging techniques indicate that brain plasticity - the brain's ability to reorganize neural pathways based on new experiences - is the compensatory mechanism largely responsible for the clinical remissions that are typical of early stages of relapsing remitting MS. The adult brain is capable of both functional and structural plasticity - processes that are operational in normal brain development such as learning and memory5.
Interestingly, functional and structural changes can also take place in the brain after injury or damage, and brain plasticity is seen to act as an adaptive mechanism to compensate for a loss of function6. Following tissue damage, the structure and function of undamaged parts of the brain can be remodeled and shaped by the sensorimotor experiences of the individual in the weeks to months following injury7, 8.

http://www.mstrust.org.uk/professionals ... 008_05.jsp

Cortical plasticity predicts recovery from relapse in multiple sclerosis.
http://www.ncbi.nlm.nih.gov/pubmed/24263385
Neuroplasticity and functional recovery in multiple sclerosis
http://www.nature.com/nrneurol/journal/ ... 2.179.html

cheer

[ribeye]

I bet the tavist will be tweaked to remove or lower the major drowsiness it causes and then marketed for about $60,000 per year. Yeah! Seriously, this was my allergy med 30 years ago and it was almost as potent as benedryl, for me anyway.
Would be cool if it does work in humans.

[1eye]

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The brain's cleaning cycle is at night (when we are asleep). Some enterprising doctor, researcher, or humanitarian might run a trial on Tavist (perhaps in parallel with what Novartis is doing) to measure efficacy of the drug if taken before bedtime. Knowing what we do about CSF movement and function, I am surprised that this kind of trial has not been done on many medications already. It may have greater efficacy at night, or only at night. This goes for all brain medications!
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[cheerleader]

More research from Karolinska showing that neuronal stimulation creates myelination in vivo.

Seriously. Use it. Got nothing to lose.

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
http://www.nature.com/neuro/journal/vao ... affil-auth

We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.

cheer

[1eye]

I still think any drug, because we are diurnal, should be tested in relation to a sleep pattern that is somehow standardized, since CSF is involved, and it is thought that sleep is required for efficient back-flushing contaminants with the CSF.

Maybe something ought to be done along those lines to quantify how important sleep is for brain drugs to be effective.

[cheerleader]

This new Karolinska research is not about drug development.
It is about activating neurons via actions/external stimulae, and causing myelin growth---nothing about chemicals.

Neuro plasticity does not require drugs. Nor does myelin, which is good news, right??


cheer

[1eye]

Heck, I bet you can use crossword puzzles!