A few Campath questions

raven · Post by **raven** » Sat Sep 19, 2009 2:21 pm

Bob,

I'm going to have to respectfully disagree with you ;) . I was referring to AHSCT which is the complete ablation of the immune system including the bone marrow, hence the need for transplantation afterwards. Cyclophosphamide is used as the ablative agent. I did point out in my post that HiCy and AHSCT were two different things.

Monoclonal means that all of the cells are genetic clones of each other, hence they can be tailored to target a specific antigen such as CD52.

Robin

Lyon · Post by **Lyon** » Sat Sep 19, 2009 2:35 pm

raven · Post by **raven** » Sat Sep 19, 2009 2:50 pm

In respectful disagreement with my friend Raven, it might be/could be/should be said that, in meeting the definition of "re-boot" both high dose Campath and Cyclophosphamide do pretty much the same thing in that it's thought that they both eliminate the immune system

Is the passage I was referring to with reference to my statement of

Revimmune treatment is not a re-boot of the immune system unless it is administered in a very high dose short course. Even then I wouldn't call it a true re-boot unless it is used in AHSCT treatment where the patients marrow is taken, the immune system entirely ablated with drugs and then the marrow re-constituted from the sample.

Short of the 'full blown' AHSCT treatment I belive that Campath and high dose Revimmune are comparable.

As we both have said HiCy and Campath are comparable, AHSCT is not, I do not believe Campath or Revimmune to be a true re-boot; therefore my disagreement was a reference to yours and meant as a friendly jibe rather than a serious disagreement.

Friends again? ;)

Robin

Lyon · Post by **Lyon** » Sat Sep 19, 2009 3:05 pm

raven · Post by **raven** » Sat Sep 19, 2009 3:10 pm

Bob,

I'm glad we're still friends and I've never really thought of you as a ditzy blonde.... Is there something you aren't telling me????