patientx wrote:Costumenastional:
There is another possibility. From the Buffalo results and anecdotal results reported here, it would seem that these stenoses are indeed seen more often in people with MS, i.e. they are associated with having MS. Assuming this true, it is possible that the stenoses are a result of having MS, or some inflammatory process associated with the MS.
This is a re-post. I would like to get your opinion.
Patient--
this is a very valid point. Certainly, we'll probably see in some instances that the progression of MS, with more inflammation and turbulent blood flow will lead to worse MS and worse stenosis.
Here's report of a recent study on this very mechanism in atherosclerosis in arteries-
We have developed a model where we disturb blood flow in the carotid artery by partial ligation, and atherosclerosis appears within two weeks," he says. "This rapid progression allows us to demonstrate cause and effect, and to examine the landmark events at the beginning of the process."
Jo says that endothelial cells, which form the inner lining of blood vessels, are equipped with sensors that detect changes in fluid flow.
"Disturbed flow is what causes the endothelial cells to become inflamed," he says.
The inflammation resulting from "bad flow" conditions in a stretch of artery causes white blood cells to accumulate there, followed by buildup of cholesterol and lipids and plaque formation.
Just 48 hours after blood flow in the carotid arteries was disturbed, Ni and colleagues dissected the carotid arteries from the mice and used genome-wide microarray technology to identify hundreds of genes that were turned on or off in the endothelial cells.
http://www.sciencedaily.com/releases/20 ... 140922.htm
What makes CCSVI different is that the doctors are finding malformations that appear to be congenital. In Jeff's case, his neck muscles are too large and tight, and pinched off his jugulars at the ears. Maybe from his trumpet playing? We don't know. In Lew and Mel's case, they had two left jugulars and weird valves, in Cat's case it was an arachnoid cyst. Some people are born with only one jugular, some are blocked by webs or membraneous obstructions. Some are pinched by vertebrae. It's a mixed bag.
But does this mean that every case of CCSVI is going to be congenital? Too soon. There may be some that are created by inflammation and disturbed flow, like the arterial example above. And maybe having MS makes it worse over time. We'll see how that pans out with more research.
hope that explains a bit,
cheer
