Vitamin K-2, also known as menaquinone, helps to remove calcium from the blood vessels by activating Gla protein.Leonard wrote:I think the real and underlying mechanism is the hardening/calcification of the veins.
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Vitamin K-2, also known as menaquinone, helps to remove calcium from the blood vessels by activating Gla protein.Leonard wrote:I think the real and underlying mechanism is the hardening/calcification of the veins.
Thank you for these insights! This global college is really unbeatable. This adds yet another very important piece of the puzzle, perhaps even the final crowning piece!MegansMom wrote:Hello Leonard and other interested parties,
I have read this thread with interest. I am an RN x almost 40 years (OMG does that say 40?)
I have a few comments to add and some more data to add.
1. Glucose is the only fuel of brain cells. It cannot be stored so it is at the mercy of the circulatory system.
2. 70% ( on average) of the bodies glucose is used as fuel by the brain cells.
During complex thinking we use more.
3. 70% of the brains blood is in the veins (venules and veins)
4. The brain (3 lbs) holds about 1.5 pints of blood at any given time.
5. 25% of our oxygen is used by the brain to burn the fuel
6. There is a polypeptide (protein) called Endothelin1. It's made by endothelium as a signaler to maintain the vessel integrity.
7. Sheer stress is the force on the endothelium when the flow is going the wrong way.
8. Hypoxia is a level of oxygen lower than what is considered normal for metabolic (cell) activity to occur at the normal rate
9. Hypoglycemia is a lower than normal glucose level . This being lower means the cell can not perform at the normal level.
10. If you block the venous outflow the glucose and the oxygen get used up by the brain cells , the blood cannot exit the desired way and the mixed blood levels of oxygen and glucose and other nutrients dip.
11. Endothelin1 rises when sheer stress goes up and hypoxia occurs.
12. Endothelin1 in high levels causes fibrosis and hypertrophy of the vessels....including vessel walls and valves.
13. PwMS have levels of Endothelin1 that are hundreds of times the normal.
14. Chronic blood turbulence will fracture red blood cells and cause deposits of iron. This can cause iron to be imbeded in the porous stressed BBB vessel walls.
15. Maybe pwCCSVI vein anomalies from birth would see the anomalies get progressively worse as the ENDOTHELIN1 levels rise in response to the chronic hypoglycemia and hypoxia and sheer stress.
16. At a tipping point the CCSVI gets to the point where the brain environment (cerebral hypoxia, hypoglycemia, oxidation of iron, etc) causes myelin and Axonai damage and death. During this phase the immune system attempts to correct the damage.
17. Eventually the immune system calls out the big guns ( B and T cells).
18. Some MS symptoms are CCSVI symptoms.
be patient.. (I know, that is not easy, I have MS myself..)MS_HOPE wrote:MegansMom, thank you VERY much for all that very helpful, concise info, for us medical semi-literates trying to comprehend all this. And thank you, Leonard, for sharing your very interesting lines of thinking. Wouldn't it be nice if "someone" out there would pick up on your ideas and do some research on them?