CCSVI and CCVBP

[uprightdoc]

This is a very interesting case study. It shows the connection between venous hypertension and neurodegenerative conditions of the cord. I cover the role of faulty craniospinal hydrodynamics in neurodegenerative conditions of the cord much more in my next paper and even more so in my next book. The affects of chronic venous hypertension are not always as obvious as this case.

As I have stated numerous times on this thread, one of my favorite authors regarding venous hypertension and degenerative conditions of the cord is Dr. Wise Young. Dr. Young is a neurosurgeon who specializes and is an expert in traumatic cord injuries. Dr. Young maintains that venous hypertension is one of the most overlooked causes of degenerative conditons of the cord. Unfortunately, most neurosurgeons still don't see the connection to the spine and upright posture yet.

http://sci.rutgers.edu/index.php?page=v ... hemia.html

[uprightdoc]

...Spinal cord ischemia can result from many causes. Obstruction of arterial blood supply to the spinal cord is the most commonly cited cause of spinal cord ischemia. Ischemic myelopathy of the spinal cord is frequently misdiagnosed as transverse myelitis. Also, many cases of spinal cord ischemia are attributed to other causes. For example, arteriovenous malformations cause ischemia. Compression of the spinal cord also can cause ischemia. Perhaps the most under appreciated cause of spinal cord ischemia is venous obstruction or congestion. Although the venous system is redundant, it is also a low pressure system that is susceptible to even mild compression and elevated venous pressures.

Spinal cord injury due to arterial, venous, and cerebrospinal fluid obstruction is far more common than we think. It is likely that they contribute significantly to the severity of spinal cord injury and failure of recovery in many causes of traumatic spinal cord injury where failure to decompress the injury site for days or weeks, poor maintenance of perfusion pressure, increased central venous pressure, and development of enlarging spinal cysts may contribute to lack of recovery or loss of function in chronic spinal cord injury...

Dr. Wise Young

[Robnl]

It's getting very interesting doc, ccsvi,lymphatic, CSF....more and more i'm convinced that the brain 'drain' IS the cause.

When i got treated for ccsvi in 2010, mental health was 'restored', physical got better and better for 6 weeks...then declined again.
(so for 6 weeks more drain 'capacity', then systems filled up again?)

So 1 problem solved, but it's not enough? 1 still exists..CSF obstruction..

Still waiting for appointment with VU-neurologist...will call them next week

[Robnl]

http://www.ncbi.nlm.nih.gov/pubmed/25724358'

Abstract

Iron accumulation occurs in the CNS in multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis (EAE). However, the mechanisms underlying such iron accumulation are not fully understood. We studied the expression and cellular localization of molecules involved in cellular iron influx, storage, and efflux. This was assessed in two mouse models of EAE: relapsing-remitting (RR-EAE) and chronic (CH-EAE). The expression of molecules involved in iron homeostasis was assessed at the onset, peak, remission/progressive and late stages of the disease.

We provide several lines of evidence for iron accumulation in the EAE spinal cord which increases with disease progression and duration, is worse in CH-EAE, and is localized in macrophages and microglia. We also provide evidence that there is a disruption of the iron efflux mechanism in macrophages/microglia that underlie the iron accumulation seen in these cells. Macrophages/microglia also lack expression of the ferroxidases (ceruloplasmin and hephaestin) which have antioxidant effects. In contrast, astrocytes which do not accumulate iron, show robust expression of several iron influx and efflux proteins and the ferroxidase ceruloplasmin which detoxifies ferrous iron.

Astrocytes therefore are capable of efficiently recycling iron from sites of EAE lesions likely into the circulation. We also provide evidence of marked dysregulation of mitochondrial function and energy metabolism genes, as well as of NADPH oxidase genes in the EAE spinal cord. This data provides the basis for the selective iron accumulation in macrophage/microglia and further evidence of severe mitochondrial dysfunction in EAE. It may provide insights into processes underling iron accumulation in MS and other neurodegenerative diseases in which iron accumulation occurs.

Bad brain 'drain'????

[Robnl]

http://www.dizziness-and-balance.com/di ... vical.html

When i twist my neck (head down-head over left shoulder-back-right shoulder-down) i experience severe dizzyness/vertigo

Also, when got my chin on my breast again i feel bones 'crack', like they shove over eachother

[uprightdoc]

It's getting very interesting doc, ccsvi,lymphatic, CSF....more and more i'm convinced that the brain 'drain' IS the cause.

When i got treated for ccsvi in 2010, mental health was 'restored', physical got better and better for 6 weeks...then declined again.
(so for 6 weeks more drain 'capacity', then systems filled up again?)

So 1 problem solved, but it's not enough? 1 still exists..CSF obstruction..

Still waiting for appointment with VU-neurologist...will call them next week

It goes beyond simply drainage Robert. It involves hydraulics in the cranial and spinal compartment (craniospinal hydrodyamics) that includes arterial blood, venous blood, CSF and interstitial fluids (ISF). Faulty craniospinal hydrodynamics can lead to chronic ischemia, edema and hydrocephalus. It can also cause increased pulsatility and destructive pressure waves.

Jugular venoplasty only improves the drainage capacity of the brain. It doesn't do anything to correct malformations and misalignments of the craniocervical junction or spondylosis, stenosis and scoliosis in the lower spine that affect craniospinal hydrodynamics.

The accumulation of Beta-amyloids, protein aggregation (tau) in AD and gamma synuclein in PD, as well as the accumulation toxins, pathogens (viruses and bacteria) and biometals such as iron, copper and zinc have all been associated with decreased CSF turnover.

[uprightdoc]

http://www.dizziness-and-balance.com/di ... vical.html

When i twist my neck (head down-head over left shoulder-back-right shoulder-down) i experience severe dizzyness/vertigo

Also, when got my chin on my breast again i feel bones 'crack', like they shove over eachother

I am very familiar with Dr. Haim. He is an expert on dizziness and vertigo. Unfortunately he is strongly opposed to chiropractic care for which he has very little knowledge and no expertise.

You have problems with vertebral-basilar ischemia which is on the arterial side of craniospinal hydrodynamics. I discuss the role of the vertebral-basilar arteries in my next paper.

[Robnl]

But, for my interpretation, isnt the result of the misalignements etc bad circulation resulting in bad drainage and then neurologic problems? (Simply stated)

[uprightdoc]

Yes. Misalignments and malformations of the craniocerivcal junction and spondylosis, stenosis and scoliosis can result in insufficient drainage and flow of venous blood and CSF. On the other hand, they can also directly affect arterial flow to the brain and cord, as well as indirectly affect flow by decreasing perfusion pressures. They can also directly cause compression of the nerves and neurological problems regardless of drainage problems or arterial flow. On the other hand they can indirectly cause neurological problems due to faulty craniospinal hydrodynamics such as in the case you posted above.

[Robnl]

Clear!

[Robnl]

Hi doc,

Arterial bloodflow; my bloodpressure used to be 130/85 (when i played soccer 120/80). The last time the gp checked it was 110/60 (2 months) ago, does that has a connection to what you are saying and the increasing dizzyness etc?

I get the impression that things get worse; mentally still ok, but more sensitive/somewhat painful neck, some pain between right shoulder and spine, dizzyness, 'cracking' when i turn my head.

[uprightdoc]

Robert, your blood pressure is on the low side but is within normal range. I strongly suspect, however, that your neck is causing obstruction to blood flow through the vertebral-basilar arteries. Consequently you get dizzy when you strain your neck in certain positions. Your neck is also painful and you get pain between the shoulder blades. In this regard, the trapezius muscle is shaped like a trapezoid. It connects the base of the skull to outer aspect of the upper shoulders and from the lower aspect of the shoulder down to the mid thoracic spine at the lower aspect of the scapula (shoulder blades), hence the pain between the right shoulder and spine. You also hear cracking when you turn your head. You need to have your neck and spine treated. When was the last time you saw your chiropractor? Flexion-distraction may no solve all you problems but it will help prevent things from getting worse, as well as addressing secondary problems caused by your current condition and disabilities. In the meantime have one of the girls massage the top of the shoulders for you but stay away for the base of the skull. Use the thumb to goad the sore spot by the right shoulder blade.

[Robnl]

Thx, i 'll see George the Chiro monday again..

[uprightdoc]

It is very important that you don't have any obstruction to blood flow through the vertebral-basilar arteries in your case Robert.

Have you heard anything about how Francis (mystery) is doing since her thoracic surgery?

[Robnl]

Hi doc,

I sent a message to Francis...

Called the VU again, they are still collecting info. they probably already know i'm not a standard guy