Phlebotomy anyone?
all right. i already started looking at what nutrients might be indicators in porphyria and actually it looks like if you have it, we might see high serum zinc. anyway i'll send you the ms list. and a link to a post i did for mirry (whose specialist was so fired up about it that he is putting all his ms patients on a supplement regimen.. SCORE!)
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I've followed through on this and high zinc shows up in AIP (Acute Intermittent Porphyria). I definitely don't have that one as mine has cutaneous symptoms and I don't get the common gut pain of AIP.jimmylegs wrote:all right. i already started looking at what nutrients might be indicators in porphyria and actually it looks like if you have it, we might see high serum zinc. anyway i'll send you the ms list. and a link to a post i did for mirry (whose specialist was so fired up about it that he is putting all his ms patients on a supplement regimen.. SCORE!)
Mine would have to be PCT porphyria cutanea Tarda (quite likely as this involved mild iron overload), or HCP or VP.
Off out now, but thanks for the PM, will read later this evening.
Cheers.....
http://www.akademiai.com/content/n5538412344u6667/
Abstract
At physiological levels, zinc and various hormones affect each other reciprocally. Reduction in zinc levels in pinealectomized rats suggests the relation between zinc and melatonin. The effect of both zinc deficiency and supplementation on plasma melatonin levels in rats were investigated in this study. The study was done in Selçuk University, Experimental Medicine Research and Application Center. Twenty-four adult male Sprague Dawley rats were divided into 3 groups. Eight rats were fed with zinc-deficient diet. Zinc supplementation was administered intraperitoneally to 8 rats. The remaining 8 rats were used as controls. All rats sacrificed 3 weeks later. Plasma melatonin and zinc levels were determined. The plasma zinc levels of the zinc-supplemented group were higher than those of the other groups as expected (P<0.01). Similarly, the melatonin levels in the zinc-supplemented group were higher than those in the other groups. A significant decrease was observed in melatonin levels of the zinc-deficient group compared to the control and zinc-supplemented group (P<0.01). The results of this study suggest that zinc deficiency decreases the melatonin levels and zinc supplementation may increase the plasma melatonin levels in rats.
can't believe i did not see this post when you originally made it merlyn [in FEBRUARY yikes sorry]!
you may already be aware that zinc deficiency also affects the body's iron handling, resulting in dysregulation and deposition.
funny that you mention AIDS - did you read the study about selenium status predicting survival in HIV+ patients?
healthy controls average 18.2-18.4 umol/L for serum zinc. that is curious that supplements did not raise your levels, there is definitely some mishandling going on there. no wonder they make you tired. have you investigated protein deficiency as a possible cause of zinc malabsorption? one of the klenner recommendations for MS is a high protein diet...Jimmylegs-last time I had zinc tested was in June 2008... my level was 10.9 reference range 9.2-26 umol/L
An excess of zinc is immunosuppressive, and I am wary of overloading on any metal. Plus the fact that I did not seem to absorb most zinc supplements, they did nothing to move the serum levels up. I am a blood type A., and I understand that this is a good range for me to be in. High levels of zinc are known to speed up AIDS. I only take 15 mg of zinc a day, oddly enough more than that makes me feel tired.
you may already be aware that zinc deficiency also affects the body's iron handling, resulting in dysregulation and deposition.
funny that you mention AIDS - did you read the study about selenium status predicting survival in HIV+ patients?
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that abstract merlyn, is that speaking to the iron binding capacity of melatonin? not the abstract itself, i just mean i know from an earlier post of yours that melatonin is on dr embry's radar for iron binding.. potentially an interesting piece of the puzzle..
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No, I just don't understand how someone can take that much zinc and still be low. There must be some confounding factor preventing proper absorption. I personally think the whole vitamin D issue in MS is related to melatonin...
http://www.edmsllc.com/research_professional.htm
Melatonin is also necessary for the absorption of zinc from the intestinal tract. A research study by Palm & Hallmans (1982) found that MS patients had lower serum zinc levels compared to age and sex matched controls. Low levels of zinc debilitate the CuZn superoxide dimutase enzyme and this results in the increase in production of lipid peroxides (Johnson, 2000). Furthermore, the demyelinated pathological areas in the CNS of MS patients showed a decreased zinc level (Yasui et al, October 1991). A study by Smith et al (1989, July) showed that there is altered copper and zinc homeostasis in MS patients. The RBC copper concentration was significantly lower in MS patients after receiving steroid therapy. This copper deficiency may correlate with the high levels of cortisol noted with the hyperactivity of the HPA axis in MS patients that increases with disease progression (Then Bergh et al, September 1999; Michelson et al, September 1994).
http://www.edmsllc.com/research_professional.htm
Melatonin is also necessary for the absorption of zinc from the intestinal tract. A research study by Palm & Hallmans (1982) found that MS patients had lower serum zinc levels compared to age and sex matched controls. Low levels of zinc debilitate the CuZn superoxide dimutase enzyme and this results in the increase in production of lipid peroxides (Johnson, 2000). Furthermore, the demyelinated pathological areas in the CNS of MS patients showed a decreased zinc level (Yasui et al, October 1991). A study by Smith et al (1989, July) showed that there is altered copper and zinc homeostasis in MS patients. The RBC copper concentration was significantly lower in MS patients after receiving steroid therapy. This copper deficiency may correlate with the high levels of cortisol noted with the hyperactivity of the HPA axis in MS patients that increases with disease progression (Then Bergh et al, September 1999; Michelson et al, September 1994).
if you have protein deficiency, a zinc deficiency could be difficult to correct with supplements.
ever had an albumin or prealbumin test? (i haven't had either one, but i would have been protein deficient at dx for sure, from the 'vegan era' hehehe)
labtestsonline.org
ever had an albumin or prealbumin test? (i haven't had either one, but i would have been protein deficient at dx for sure, from the 'vegan era' hehehe)
labtestsonline.org
2. What is the difference between prealbumin, albumin, and microalbumin tests?
Albumin and microalbumin are the same molecule while prealbumin, despite the similar-sounding name, is a completely unrelated molecule. The prealbumin test measures a protein that reflects your current nutritional status. Albumin testing is more often used to test for liver or kidney disease or to learn if your body is not absorbing enough amino acids. Albumin can also be used to monitor nutritional status and is a more widely available test than prealbumin. However, prealbumin changes more quickly, making it more useful for detecting changes in short-term nutritional status than albumin
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http://www.life-enhancement.com/article ... asp?id=594
VINPOCETINE - VIAGRA FOR THE BRAIN
Chemical compounds that expand the blood vessels in this manner are called vasodilators. One such molecule, vinpocetine, has been used for many years in the treatment of senile dementia (age-related dementia, or what used to be called senility), as well as for a variety of other conditions that benefit from increased blood flow. Dementia is defined as a progressive loss of memory accompanied by significant impairment in other areas of mental function or behavior - or, to put it simply, it's losing one's marbles.
Vinpocetine is known to enhance cerebral blood flow, which boosts the amounts of life-giving (and energy-producing) oxygen and glucose delivered to the brain cells.1 In this regard it's not unlike a well-known drug that is known to enhance blood flow to another part of the body. No wonder vinpocetine is called "Viagra® for the brain," especially when you consider that the brain is, after all, the body's most important sex organ.
http://www.iherb.com/Source-Naturals-Vi ... /1503?at=1
VINPOCETINE - VIAGRA FOR THE BRAIN
Chemical compounds that expand the blood vessels in this manner are called vasodilators. One such molecule, vinpocetine, has been used for many years in the treatment of senile dementia (age-related dementia, or what used to be called senility), as well as for a variety of other conditions that benefit from increased blood flow. Dementia is defined as a progressive loss of memory accompanied by significant impairment in other areas of mental function or behavior - or, to put it simply, it's losing one's marbles.
Vinpocetine is known to enhance cerebral blood flow, which boosts the amounts of life-giving (and energy-producing) oxygen and glucose delivered to the brain cells.1 In this regard it's not unlike a well-known drug that is known to enhance blood flow to another part of the body. No wonder vinpocetine is called "Viagra® for the brain," especially when you consider that the brain is, after all, the body's most important sex organ.
http://www.iherb.com/Source-Naturals-Vi ... /1503?at=1
Good article...
http://www.life-enhancement.com/article ... asp?id=187
On one of the other forums, there is a guy that claims to this product Venotonic is keeping him absolutely healthy and it brings him out of exacerbations...
http://www.life-enhancement.com/article ... asp?ID=148
http://www.life-enhancement.com/article ... asp?id=187
On one of the other forums, there is a guy that claims to this product Venotonic is keeping him absolutely healthy and it brings him out of exacerbations...
http://www.life-enhancement.com/article ... asp?ID=148
http://blog.norml.org/2010/09/14/dr-and ... revention/
But perhaps most exciting, cannabinoids (chemical constituents of Cannabis, the best known being tetrahydrocannabinol or THC) may have a primary role in cancer treatment and prevention. A number of studies have shown that these compounds can inhibit tumor growth in laboratory animal models. In part, this is achieved by inhibiting angiogenesis, the formation of new blood vessels that tumors need in order to grow. What’s more, cannabinoids seem to kill tumor cells without affecting surrounding normal cells. If these findings hold true as research progresses, cannabinoids would demonstrate a huge advantage over conventional chemotherapy agents, which too often destroy normal cells as well as cancer cells.
But perhaps most exciting, cannabinoids (chemical constituents of Cannabis, the best known being tetrahydrocannabinol or THC) may have a primary role in cancer treatment and prevention. A number of studies have shown that these compounds can inhibit tumor growth in laboratory animal models. In part, this is achieved by inhibiting angiogenesis, the formation of new blood vessels that tumors need in order to grow. What’s more, cannabinoids seem to kill tumor cells without affecting surrounding normal cells. If these findings hold true as research progresses, cannabinoids would demonstrate a huge advantage over conventional chemotherapy agents, which too often destroy normal cells as well as cancer cells.
Hi everyone, I had my Phleb last week, and came straight down with a nasty flu that evening, and then a chest infection, so I've been on antibiotics for a week! All better now, and I am finally getting to enjoy my high energy levels and freedom of movement in my joints.
I'm getting a great nights sleep also, the pain in my hips goes away instantly with the phlebs.
I have one more task, that hopefully will bring down my high hemoglobin levels. I have never admitted it here before, but I am a smoker
and I've never been able to give it up. I'm not proud of it in any way. That's my last task, and hopefully one that will finish off the job so to speak. Smoking can make your body create more hemoglobin to compensate for the lost oxygen in the blood. Another tie-in with the CCSVI theory of deoxygenated blood maybe.
Anyway, this is it, i have to do it!
I'll get my bloods tested in November, smoke free by then, and see how it goes.
I'm getting a great nights sleep also, the pain in my hips goes away instantly with the phlebs.
I have one more task, that hopefully will bring down my high hemoglobin levels. I have never admitted it here before, but I am a smoker
and I've never been able to give it up. I'm not proud of it in any way. That's my last task, and hopefully one that will finish off the job so to speak. Smoking can make your body create more hemoglobin to compensate for the lost oxygen in the blood. Another tie-in with the CCSVI theory of deoxygenated blood maybe.Anyway, this is it, i have to do it!
I'll get my bloods tested in November, smoke free by then, and see how it goes.