2022 Sep 20
Department of Chemistry, University of California, Berkeley, United States
Elucidating Contributions of Anthropogenic Volatile Organic Compounds and Particulate Matter to Ozone Trends over China
https://pubmed.ncbi.nlm.nih.gov/36083302/
Tropospheric ozone
Re: Tropospheric ozone
https://www.eboro.cz
Re: Tropospheric ozone
2022 Sep 9
Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, China
The association between air pollution, meteorological factors, and daily outpatient visits for urticaria in Shijiazhuang, Hebei Province, China: a time series analysis
----------------------------------
May 01, 2019
msard-journal
Hypocomplementemic urticarial vasculitis and multiple Sclerosis: A rare association or an atypical presentation?
https://www.msard-journal.com/article/S ... X/fulltext
Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, China
The association between air pollution, meteorological factors, and daily outpatient visits for urticaria in Shijiazhuang, Hebei Province, China: a time series analysis
----------------------------------
May 01, 2019
msard-journal
Hypocomplementemic urticarial vasculitis and multiple Sclerosis: A rare association or an atypical presentation?
https://www.msard-journal.com/article/S ... X/fulltext
https://www.eboro.cz
Re: Tropospheric ozone
O3
2022 Sep 6
Department of Clinical Medicine, The Second School of Clinical Medicine, Anhui Medical University, China
Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis
https://pubmed.ncbi.nlm.nih.gov/36141453/
Abstract
At present, ambient air pollution poses a significant threat to patients with cardiovascular disease (CVD). The heart rate variability (HRV) is a marker of the cardiac autonomic nervous system, and it is related to air pollution and cardiovascular disease. There is, however, considerable disagreement in the literature regarding the association between ozone (O3) and HRV ...
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MS
2018 Aug
Marmara University School of Medicine, Department of Neurology, Istanbul, Turkey
Heart rate variability analysis in patients with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/29957350/
Abstract
Background: Multiple sclerosis can cause cardiovascular autonomic dysfunction. It is assumed that is caused by multiple demyelinating plaques localized in the brain stem and spinal cord. Previous studies have determined this using tilt table test, heart rate responses to Valsalva maneuver and deep breathing and heart rate variability analysis with 24 h Holter monitoring. However there is not a consensus regarding the presence of the relationship between autonomic dysfunction and severity of multiple sclerosis, type of multiple sclerosis and expanded disability status scale. The aim of the study is comparison of heart rate variability between recently diagnosed patients with relapsing-remitting multiple sclerosis and healthy controls by using 24 h Holter monitoring. Also we intended to investigate relationship between Expanded Disability Status Scale score, Multiple Sclerosis Functional Composite scores and cranial and spinal magnetic resonance imaging findings and hearth rate variability...
2022 Sep 6
Department of Clinical Medicine, The Second School of Clinical Medicine, Anhui Medical University, China
Association between Short-Term Exposure to Ozone and Heart Rate Variability: A Systematic Review and Meta-Analysis
https://pubmed.ncbi.nlm.nih.gov/36141453/
Abstract
At present, ambient air pollution poses a significant threat to patients with cardiovascular disease (CVD). The heart rate variability (HRV) is a marker of the cardiac autonomic nervous system, and it is related to air pollution and cardiovascular disease. There is, however, considerable disagreement in the literature regarding the association between ozone (O3) and HRV ...
-----------------------------------------------------------------------------------
MS
2018 Aug
Marmara University School of Medicine, Department of Neurology, Istanbul, Turkey
Heart rate variability analysis in patients with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/29957350/
Abstract
Background: Multiple sclerosis can cause cardiovascular autonomic dysfunction. It is assumed that is caused by multiple demyelinating plaques localized in the brain stem and spinal cord. Previous studies have determined this using tilt table test, heart rate responses to Valsalva maneuver and deep breathing and heart rate variability analysis with 24 h Holter monitoring. However there is not a consensus regarding the presence of the relationship between autonomic dysfunction and severity of multiple sclerosis, type of multiple sclerosis and expanded disability status scale. The aim of the study is comparison of heart rate variability between recently diagnosed patients with relapsing-remitting multiple sclerosis and healthy controls by using 24 h Holter monitoring. Also we intended to investigate relationship between Expanded Disability Status Scale score, Multiple Sclerosis Functional Composite scores and cranial and spinal magnetic resonance imaging findings and hearth rate variability...
https://www.eboro.cz
Re: Tropospheric ozone
2022 Sep 26Petr75 wrote: ↑Thu Oct 06, 2022 12:01 pm 2022 Sep 9
Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, China
The association between air pollution, meteorological factors, and daily outpatient visits for urticaria in Shijiazhuang, Hebei Province, China: a time series analysis
----------------------------------
May 01, 2019
msard-journal
Hypocomplementemic urticarial vasculitis and multiple Sclerosis: A rare association or an atypical presentation?
https://www.msard-journal.com/article/S ... X/fulltext
Department of Dermatology, Shengjing Hospital of China Medical University, China
The differential impact of air pollutants on acute urticaria and chronic urticaria: a time series analysis
https://pubmed.ncbi.nlm.nih.gov/36161569/
..In summary, these results suggest that short-term O3, PM2.5, and PM10 exposure can increase the risk of acute urticaria and chronic urticaria.
https://www.eboro.cz
Re: Tropospheric ozone
O3
January 2012
researchgate.net
Seasonal Variations of Tropospheric Ozone Concentrations
https://www.researchgate.net/publicatio ... entrations
.. Abstract -This study shows strong seasonality of ground level ozone concentrations with spring (September and October) maximum and winter (May and June) minimum levels
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MS
2022 Sep 28
Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Seasonal and monthly variation in multiple sclerosis relapses: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/36171477/
Conclusion: Our systematic review and meta-analysis confirm the temporal fluctuations in the relapse of MS through a comprehensive review of the existing literature, with a lower relapse rate during late summer and fall and a higher relapse rate during early spring.
January 2012
researchgate.net
Seasonal Variations of Tropospheric Ozone Concentrations
https://www.researchgate.net/publicatio ... entrations
.. Abstract -This study shows strong seasonality of ground level ozone concentrations with spring (September and October) maximum and winter (May and June) minimum levels
------------
MS
2022 Sep 28
Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Seasonal and monthly variation in multiple sclerosis relapses: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/36171477/
Conclusion: Our systematic review and meta-analysis confirm the temporal fluctuations in the relapse of MS through a comprehensive review of the existing literature, with a lower relapse rate during late summer and fall and a higher relapse rate during early spring.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2018
Université Claude Bernard Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Center, Lyon, France
Ozone Atmospheric Pollution and Alzheimer's Disease: From Epidemiological Facts to Molecular Mechanisms
https://pubmed.ncbi.nlm.nih.gov/29480184/
------------------------------
MS
2022 Nov
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston
Association of autoimmune diseases with Alzheimer's disease: A mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/36198219/
..Conclusion: Liability to multiple sclerosis and Sjogren's syndrome could be associated with Alzheimer's disease. The underlying mechanisms, such as the role of myelin and neuroinflammation, should be further investigated.
2018
Université Claude Bernard Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Center, Lyon, France
Ozone Atmospheric Pollution and Alzheimer's Disease: From Epidemiological Facts to Molecular Mechanisms
https://pubmed.ncbi.nlm.nih.gov/29480184/
------------------------------
MS
2022 Nov
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston
Association of autoimmune diseases with Alzheimer's disease: A mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/36198219/
..Conclusion: Liability to multiple sclerosis and Sjogren's syndrome could be associated with Alzheimer's disease. The underlying mechanisms, such as the role of myelin and neuroinflammation, should be further investigated.
https://www.eboro.cz
Re: Tropospheric ozone
O3 (21.11.2022)
2022 Nov
Department of Occupational Health and Environmental Health, School of Public Health, Hebei Medical University, Shijiazhuang, China
Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats
https://pubmed.ncbi.nlm.nih.gov/36228356/
Abstract
Ozone pollution has been associated with several adverse effects, including memory impairment, intellectual retardation, emotional disturbances. However, the potential mechanisms remain uncertain. The present study aimed to investigate whether ozone (O3) regulates synaptic plasticity through PI3K/Akt/GSK3β signaling pathway and induces neurobehavioral modifications among the young rats...
--------------------------------------------
August 24, 2011
PlosOne
Critical Role of PI3K/Akt/GSK3β in Motoneuron Specification from Human Neural Stem Cells in Response to FGF2 and EGF
https://journals.plos.org/plosone/artic ... ne.0023414
--------------------------------------------
June 2014
Dietary regulation of PI3K/AKT/GSK-3 beta pathway in Alzheimer's disease
https://www.researchgate.net/publicatio ... 7s_disease
--------------------------------------------
Don't try anything, don't test. I don't have to be right.
I used to fix machines - no people!
2022 Nov
Department of Occupational Health and Environmental Health, School of Public Health, Hebei Medical University, Shijiazhuang, China
Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats
https://pubmed.ncbi.nlm.nih.gov/36228356/
Abstract
Ozone pollution has been associated with several adverse effects, including memory impairment, intellectual retardation, emotional disturbances. However, the potential mechanisms remain uncertain. The present study aimed to investigate whether ozone (O3) regulates synaptic plasticity through PI3K/Akt/GSK3β signaling pathway and induces neurobehavioral modifications among the young rats...
--------------------------------------------
August 24, 2011
PlosOne
Critical Role of PI3K/Akt/GSK3β in Motoneuron Specification from Human Neural Stem Cells in Response to FGF2 and EGF
https://journals.plos.org/plosone/artic ... ne.0023414
--------------------------------------------
June 2014
Dietary regulation of PI3K/AKT/GSK-3 beta pathway in Alzheimer's disease
https://www.researchgate.net/publicatio ... 7s_disease
--------------------------------------------
Don't try anything, don't test. I don't have to be right.
I used to fix machines - no people!
https://www.eboro.cz
Re: Tropospheric ozone
2022 Aug 23
Center for Environmental Measurement and Modeling, Office of Research and Development, U.S. Environmental Protection Agency, RTP, NC, USA
How have Divergent Global Emission Trends Influenced Long-range Transported Ozone to North America?
https://pubmed.ncbi.nlm.nih.gov/36275858/
--------------------------------------------
2022 Oct 21
International School of Public Health and One Health, Hainan Medical University, Haikou, China
Combined exposure of heat stress and ozone enhanced cognitive impairment via neuroinflammation and blood brain barrier disruption in male rats
https://pubmed.ncbi.nlm.nih.gov/36280063/
---------------------------------------------
2022 Oct 27
Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown
Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity
https://pubmed.ncbi.nlm.nih.gov/36303316/
...Air pollution accounts for more than 7 million premature deaths worldwide. Using ultrafine carbon black (CB) and ozone (O3) as a model for an environmental co-exposure scenario..
-----------------------------------------------
2022 Oct 27
State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, the Chinese Academy of Sciences, Beijing, China
Elevated ozone decreases the multifunctionality of belowground ecosystems
https://pubmed.ncbi.nlm.nih.gov/36300607/
....The significant negative relationships between O3 -treated intensity and the multifunctionality index for croplands, forests, and grasslands implied that elevated [O3 ] decreases belowground ecosystem multifunctionality.
Center for Environmental Measurement and Modeling, Office of Research and Development, U.S. Environmental Protection Agency, RTP, NC, USA
How have Divergent Global Emission Trends Influenced Long-range Transported Ozone to North America?
https://pubmed.ncbi.nlm.nih.gov/36275858/
--------------------------------------------
2022 Oct 21
International School of Public Health and One Health, Hainan Medical University, Haikou, China
Combined exposure of heat stress and ozone enhanced cognitive impairment via neuroinflammation and blood brain barrier disruption in male rats
https://pubmed.ncbi.nlm.nih.gov/36280063/
---------------------------------------------
2022 Oct 27
Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown
Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity
https://pubmed.ncbi.nlm.nih.gov/36303316/
...Air pollution accounts for more than 7 million premature deaths worldwide. Using ultrafine carbon black (CB) and ozone (O3) as a model for an environmental co-exposure scenario..
-----------------------------------------------
2022 Oct 27
State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, the Chinese Academy of Sciences, Beijing, China
Elevated ozone decreases the multifunctionality of belowground ecosystems
https://pubmed.ncbi.nlm.nih.gov/36300607/
....The significant negative relationships between O3 -treated intensity and the multifunctionality index for croplands, forests, and grasslands implied that elevated [O3 ] decreases belowground ecosystem multifunctionality.
https://www.eboro.cz
Re: Tropospheric ozone
01 November 2022
nature.com
Evidence of air pollution-related ocular signs and altered inflammatory cytokine profile of the ocular surface in Beijing
https://www.nature.com/articles/s41598-022-23294-7
Abstract
We evaluated how different degrees of air pollution affect the ocular surface of a cohort of human subjects in Beijing by correlating in-patient test outcomes with tear cytokines. A cross-sectional study involving 221 volunteers was carried out in different districts of Beijing. Air pollution indices were recorded for 7 d (including the visit day). The indices recorded were the air quality index (AQI), which is a dimensionless measure that quantitatively describes the state of air quality, concentrations of particulate matter smaller than 2.5 μm (PM2.5) and 10 μm (PM10), sulfur dioxide (SO2), ozone (O3), and nitrogen dioxide (NO2)...
-------------------------------------------------
This study is the first many-sided study of the effects of air pollution on ocular surface-related inflammation, symptoms and signs.
Numerous studies both in vivo and in vitro have demonstrated the upregulation of cytokines on the ocular surface after exposure to air pollution.
found that human corneal and conjunctival epithelial cells incubated with diesel exhaust particles showed cytotoxicity and an inflammatory response mediated by the cytokine IL-6
Activation of inflammatory pathways and oxidative stress are considered potential mechanisms involved in the pathogenesis of ocular surface diseases after air pollution exposure
The IL-6 concentration was positively correlated with the AQI, PM2.5, PM10 and NO 2 concentrations and negatively correlated with the concentrations of O 3
Goblet-cell density was positively correlated with AQI, PM2.5, PM10 and NO2 concentrations and negatively correlated with O 3 concentrations.
A significant difference in the concentrations of inflammatory cytokines between the two groups was observed, also demonstrating that increasing air pollution degrees can cause ocular inflammatory reactions, which leads to significantly elevated tear cytokines.
Lee (52) reported increased concentrations of IL-1β, IL-6, IL-17, and interferon gamma in a murine model exposed to ozone chambers for one or two weeks.
----------------------------------
1. 1. 2014 — We proposed here that the exploration of tears from multiple sclerosis patients could lead to the discovery of new biomarkers. https://onlinelibrary.wiley.com/doi/10. ... .201300053
nature.com
Evidence of air pollution-related ocular signs and altered inflammatory cytokine profile of the ocular surface in Beijing
https://www.nature.com/articles/s41598-022-23294-7
Abstract
We evaluated how different degrees of air pollution affect the ocular surface of a cohort of human subjects in Beijing by correlating in-patient test outcomes with tear cytokines. A cross-sectional study involving 221 volunteers was carried out in different districts of Beijing. Air pollution indices were recorded for 7 d (including the visit day). The indices recorded were the air quality index (AQI), which is a dimensionless measure that quantitatively describes the state of air quality, concentrations of particulate matter smaller than 2.5 μm (PM2.5) and 10 μm (PM10), sulfur dioxide (SO2), ozone (O3), and nitrogen dioxide (NO2)...
-------------------------------------------------
This study is the first many-sided study of the effects of air pollution on ocular surface-related inflammation, symptoms and signs.
Numerous studies both in vivo and in vitro have demonstrated the upregulation of cytokines on the ocular surface after exposure to air pollution.
found that human corneal and conjunctival epithelial cells incubated with diesel exhaust particles showed cytotoxicity and an inflammatory response mediated by the cytokine IL-6
Activation of inflammatory pathways and oxidative stress are considered potential mechanisms involved in the pathogenesis of ocular surface diseases after air pollution exposure
The IL-6 concentration was positively correlated with the AQI, PM2.5, PM10 and NO 2 concentrations and negatively correlated with the concentrations of O 3
Goblet-cell density was positively correlated with AQI, PM2.5, PM10 and NO2 concentrations and negatively correlated with O 3 concentrations.
A significant difference in the concentrations of inflammatory cytokines between the two groups was observed, also demonstrating that increasing air pollution degrees can cause ocular inflammatory reactions, which leads to significantly elevated tear cytokines.
Lee (52) reported increased concentrations of IL-1β, IL-6, IL-17, and interferon gamma in a murine model exposed to ozone chambers for one or two weeks.
----------------------------------
1. 1. 2014 — We proposed here that the exploration of tears from multiple sclerosis patients could lead to the discovery of new biomarkers. https://onlinelibrary.wiley.com/doi/10. ... .201300053
https://www.eboro.cz
Re: Tropospheric ozone
O3
American Journal of Respiratory Cell and Molecular Biology
Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys.
https://www.atsjournals.org/doi/abs/10. ... ode=ajrcmb
Abstract
The current studies were designed to test two hypotheses: (1) differences in steady-state reduced glutathione levels are responsible for subcompartment differences in susceptibility to acute ozone injury, and (2) elevation of reduced glutathione concentrations accounts for the tolerance to further injury produced by repeated ozone exposure. Glutathione was measured in well-defined subcompartments of the lung of both rats and monkeys to compare alterations occurring in both target....
---------------------------------------------------------
MS
2014 May 19
Vrije Universiteit (VU) University Medical Center Amsterdam, The Netherlands
Glutathione in multiple sclerosis: more than just an antioxidant?
https://pubmed.ncbi.nlm.nih.gov/24842957/
Abstract
Oxidative stress has been strongly implicated in both the inflammatory and neurodegenerative pathological mechanisms in multiple sclerosis (MS). In response to oxidative stress, cells increase and activate their cellular antioxidant mechanisms. Glutathione (GSH) is the major antioxidant in the brain, and as such plays a pivotal role in the detoxification of reactive oxidants. Previous research has shown that GSH homeostasis is altered in MS. In this review, we provide a comprehensive overview on GSH metabolism in brain cells, with a focus on its involvement in MS. The potential of GSH as an in vivo biomarker in MS is discussed, along with a short overview of improvements in imaging methods that allow non-invasive quantification of GSH in the brain..
American Journal of Respiratory Cell and Molecular Biology
Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys.
https://www.atsjournals.org/doi/abs/10. ... ode=ajrcmb
Abstract
The current studies were designed to test two hypotheses: (1) differences in steady-state reduced glutathione levels are responsible for subcompartment differences in susceptibility to acute ozone injury, and (2) elevation of reduced glutathione concentrations accounts for the tolerance to further injury produced by repeated ozone exposure. Glutathione was measured in well-defined subcompartments of the lung of both rats and monkeys to compare alterations occurring in both target....
---------------------------------------------------------
MS
2014 May 19
Vrije Universiteit (VU) University Medical Center Amsterdam, The Netherlands
Glutathione in multiple sclerosis: more than just an antioxidant?
https://pubmed.ncbi.nlm.nih.gov/24842957/
Abstract
Oxidative stress has been strongly implicated in both the inflammatory and neurodegenerative pathological mechanisms in multiple sclerosis (MS). In response to oxidative stress, cells increase and activate their cellular antioxidant mechanisms. Glutathione (GSH) is the major antioxidant in the brain, and as such plays a pivotal role in the detoxification of reactive oxidants. Previous research has shown that GSH homeostasis is altered in MS. In this review, we provide a comprehensive overview on GSH metabolism in brain cells, with a focus on its involvement in MS. The potential of GSH as an in vivo biomarker in MS is discussed, along with a short overview of improvements in imaging methods that allow non-invasive quantification of GSH in the brain..
https://www.eboro.cz
Re: Tropospheric ozone
O3
DeHaven, Wesley (2022)
Master Essay, University of Pittsburgh
Association of Air Pollution and Blood-Based Biomarkers of Brain Degeneration
http://d-scholarship.pitt.edu/42900/
Introduction: Air pollution contributes to poorer brain health and Alzheimer’s Disease (AD) incidence although the biological mechanisms remain unclear. The aim of these analyses is to evaluate the association between air pollutants (Particulate Matter (PM10), Ozone (O3,),...
Conclusion: In adults aged 65 and older, long term air pollutant exposure was significantly associated with higher levels of degeneration biomarkers. The association may provide evidence that AD may be in the early stages, as higher levels of NfL precede the first clinical manifestations of AD, and GFAP has been associated with AD pathology. Further research could raise awareness on AD and the current public health relevance of air pollution and its disproportional health disparities from exposure.
----------------------------------------------
MS
2022 Nov 14
Harvard Medical School .... Basel, Switzerland
Serum GFAP and NfL Levels Differentiate Subsequent Progression and Disease Activity in Patients With Progressive Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/36376097/
DeHaven, Wesley (2022)
Master Essay, University of Pittsburgh
Association of Air Pollution and Blood-Based Biomarkers of Brain Degeneration
http://d-scholarship.pitt.edu/42900/
Introduction: Air pollution contributes to poorer brain health and Alzheimer’s Disease (AD) incidence although the biological mechanisms remain unclear. The aim of these analyses is to evaluate the association between air pollutants (Particulate Matter (PM10), Ozone (O3,),...
Conclusion: In adults aged 65 and older, long term air pollutant exposure was significantly associated with higher levels of degeneration biomarkers. The association may provide evidence that AD may be in the early stages, as higher levels of NfL precede the first clinical manifestations of AD, and GFAP has been associated with AD pathology. Further research could raise awareness on AD and the current public health relevance of air pollution and its disproportional health disparities from exposure.
----------------------------------------------
MS
2022 Nov 14
Harvard Medical School .... Basel, Switzerland
Serum GFAP and NfL Levels Differentiate Subsequent Progression and Disease Activity in Patients With Progressive Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/36376097/
https://www.eboro.cz