O3
2023 Aug 1
Oak Ridge Institute for Science and Education, Oak Ridge, USA
Effects of Controlled Ozone Exposure on Circulating microRNAs and Vascular and Coagulation Biomarkers: A Mediation Analysis
https://pubmed.ncbi.nlm.nih.gov/37624035/
...Mediation analysis showed that miR-19a-3p may be a significant mediator of O3-exposure-induced changes in blood TNFα levels
...The results showed that the expression level of multiple circulating miRNAs (e.g., miR-19a-3p, miR-34a-5p) was significantly associated with O3 exposure
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MS
2021 Aug
MicroRNAs, Multiple Sclerosis, and Depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346048/
...Blood samples from 40 RRMS patients and 20 healthy volunteers were investigated. The expression levels of miR-34a, miR-199a, miR-30c, and miR-19a, and the percentage of Th17 and Treg cells were measured.
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MS
2018 Jun 15
Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients
https://pubmed.ncbi.nlm.nih.gov/29551498/
Tropospheric ozone
Re: Tropospheric ozone
https://www.eboro.cz
Re: Tropospheric ozone
2023 Aug 29
Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, Kancheepuram, Tamil Nadu, Indi
OZONE-INDUCED NEUROTOXICITY: IN VITRO AND IN VIVO EVIDENCE
https://pubmed.ncbi.nlm.nih.gov/37652313/
Abstract
Together with cities in higher-income nations, it is anticipated that the real global ozone is rising in densely populated areas of Asia and Africa. This review aims to discuss the possible neurotoxic pollutants and ozone-induced neurotoxicity: in vitro and in vivo, along with possible biomarkers to assess ozone-related oxidative stress. As a methodical and scientific strategy for hazard identification and risk characterization of human chemical exposures, toxicological risk assessment is increasingly being implemented. While traditional methods are followed by in vitro toxicology, cell culture techniques are being investigated in modern toxicology. In both human and rodent models, aging makes the olfactory circuitry vulnerable to spreading immunological responses from the periphery to the brain because it lacks the blood-brain barrier. The ozone toxicity is elusive as it shows ventral and dorsal root injury cases even in the milder dose. Its potential toxicity should be disclosed to understand further the clear mechanism insights of how it acts in cellular aspects. Human epidemiological research has confirmed the conclusions that prenatal and postnatal exposure to high levels of air pollution are linked to behavioral alterations in offspring. O3 also enhances blood circulation. It has antibacterial action, which may have an impact on the gut microbiota. It also activates immunological, anti-inflammatory, proteasome, and growth factor signaling Prolonged O3 exposure causes oxidative damage to plasma proteins and lipids and damages the structural and functional integrity of the mitochondria. Finally, various studies need to be conducted to identify the potential biomarkers associated with ozone and the brain.
Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, Kancheepuram, Tamil Nadu, Indi
OZONE-INDUCED NEUROTOXICITY: IN VITRO AND IN VIVO EVIDENCE
https://pubmed.ncbi.nlm.nih.gov/37652313/
Abstract
Together with cities in higher-income nations, it is anticipated that the real global ozone is rising in densely populated areas of Asia and Africa. This review aims to discuss the possible neurotoxic pollutants and ozone-induced neurotoxicity: in vitro and in vivo, along with possible biomarkers to assess ozone-related oxidative stress. As a methodical and scientific strategy for hazard identification and risk characterization of human chemical exposures, toxicological risk assessment is increasingly being implemented. While traditional methods are followed by in vitro toxicology, cell culture techniques are being investigated in modern toxicology. In both human and rodent models, aging makes the olfactory circuitry vulnerable to spreading immunological responses from the periphery to the brain because it lacks the blood-brain barrier. The ozone toxicity is elusive as it shows ventral and dorsal root injury cases even in the milder dose. Its potential toxicity should be disclosed to understand further the clear mechanism insights of how it acts in cellular aspects. Human epidemiological research has confirmed the conclusions that prenatal and postnatal exposure to high levels of air pollution are linked to behavioral alterations in offspring. O3 also enhances blood circulation. It has antibacterial action, which may have an impact on the gut microbiota. It also activates immunological, anti-inflammatory, proteasome, and growth factor signaling Prolonged O3 exposure causes oxidative damage to plasma proteins and lipids and damages the structural and functional integrity of the mitochondria. Finally, various studies need to be conducted to identify the potential biomarkers associated with ozone and the brain.
https://www.eboro.cz
Re: Tropospheric ozone
2023 Sep 4
Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, China
Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk: a multicenter maternal-fetal medicine study
https://pubmed.ncbi.nlm.nih.gov/37665504/
Conclusions: Maternal O3 exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring, which calls for effective measures to decrease maternal exposure to O3 pollution and secondhand smoke for CHD prevention.
Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, China
Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk: a multicenter maternal-fetal medicine study
https://pubmed.ncbi.nlm.nih.gov/37665504/
Conclusions: Maternal O3 exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring, which calls for effective measures to decrease maternal exposure to O3 pollution and secondhand smoke for CHD prevention.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Sep 2
School of Public Health, Xinxiang Medical University, Xinxiang, China
High temperature exacerbates ozone-induced airway inflammation: Implication of airway microbiota and metabolites
https://pubmed.ncbi.nlm.nih.gov/37666337/
...Short-term exposure to ozone (O3) has been associated with airway inflammation. Given that high temperature (HT) accelerates O3 production, it is of significance to determine whether co-exposure to HT exacerbates O3-induced airway inflammation...
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MS
2018 Sep 5
Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205043/
2023 Sep 2
School of Public Health, Xinxiang Medical University, Xinxiang, China
High temperature exacerbates ozone-induced airway inflammation: Implication of airway microbiota and metabolites
https://pubmed.ncbi.nlm.nih.gov/37666337/
...Short-term exposure to ozone (O3) has been associated with airway inflammation. Given that high temperature (HT) accelerates O3 production, it is of significance to determine whether co-exposure to HT exacerbates O3-induced airway inflammation...
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MS
2018 Sep 5
Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205043/
https://www.eboro.cz
Re: Tropospheric ozone
Last edited by Petr75 on Sat Apr 20, 2024 11:22 pm, edited 2 times in total.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2016 Jan 7
Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703985/
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November - December 2021
Effect of exposure to low doses of ozone on interleukin 17A expression during progressive neurodegeneration in the rat hippocampus
https://www.elsevier.es/en-revista-neur ... 0820301838
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MS
2023 Sep 4
Department of Pharmacy, International Islamic University Chittagong, Bangladesh
Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases
https://pubmed.ncbi.nlm.nih.gov/37670700/
...Results: IL-17 cytokines, particularly IL-17A, have been implicated in the development of various inflammatory and autoimmune disorders
2016 Jan 7
Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703985/
--------
November - December 2021
Effect of exposure to low doses of ozone on interleukin 17A expression during progressive neurodegeneration in the rat hippocampus
https://www.elsevier.es/en-revista-neur ... 0820301838
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MS
2023 Sep 4
Department of Pharmacy, International Islamic University Chittagong, Bangladesh
Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases
https://pubmed.ncbi.nlm.nih.gov/37670700/
...Results: IL-17 cytokines, particularly IL-17A, have been implicated in the development of various inflammatory and autoimmune disorders
https://www.eboro.cz
Re: Tropospheric ozone
O3
IL-10/IL-10R axis
2010 Sep 8
Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002191/
..The mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators.
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MS
2023 Aug 3
Department of Immunology, University of Toronto, Toronto, ON, Canada
Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis
https://pubmed.ncbi.nlm.nih.gov/37600781/
IL-10/IL-10R axis
2010 Sep 8
Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002191/
..The mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators.
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MS
2023 Aug 3
Department of Immunology, University of Toronto, Toronto, ON, Canada
Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis
https://pubmed.ncbi.nlm.nih.gov/37600781/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2012 Jun
Department of Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr, Mainz, Germany
Impact of ozone exposure on prostaglandin release in nasal polyps
https://pubmed.ncbi.nlm.nih.gov/22130916/
...Ozone is an air pollutant with known proinflammatory effects on exposed epithelia, however, its impact on the expression of the cyclooxygenases 1 and 2 (cox1/2) and prostaglandin
---------------------------------
MS
2023 Aug 24
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China
The causal relationship between multiple autoimmune diseases and nasal polyps
https://pubmed.ncbi.nlm.nih.gov/37691921/
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2020
Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, India
Role of Prostaglandins in Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/31914903/
2012 Jun
Department of Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr, Mainz, Germany
Impact of ozone exposure on prostaglandin release in nasal polyps
https://pubmed.ncbi.nlm.nih.gov/22130916/
...Ozone is an air pollutant with known proinflammatory effects on exposed epithelia, however, its impact on the expression of the cyclooxygenases 1 and 2 (cox1/2) and prostaglandin
---------------------------------
MS
2023 Aug 24
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China
The causal relationship between multiple autoimmune diseases and nasal polyps
https://pubmed.ncbi.nlm.nih.gov/37691921/
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2020
Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, India
Role of Prostaglandins in Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/31914903/
https://www.eboro.cz
Re: Tropospheric ozone
MS
2023 Aug 10
Department of Neurology, Sichuan Taikang Hospital, Chengdu, Sichuan, China
Unraveling the link: exploring the causal relationship between diabetes, multiple sclerosis, migraine, and Alzheimer's disease through Mendelian randomization
https://pubmed.ncbi.nlm.nih.gov/37694124/
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O3
30 March 2023
The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
https://ehjournal.biomedcentral.com/art ... 23-00981-0
..Long-term exposure to ozone may increase the risk of T2D
----------------
Oct 7, 2019
Can Weather or Air Pollution Trigger Migraine?
https://www.news-medical.net/health/Can ... raine.aspx
...In addition, traffic-related pollutants, such as ozone precursors and carbon monoxide, are known to induce migraine headache, particularly in cold climates
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2018
Université Claude Bernard Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Center, Lyon, France
Ozone Atmospheric Pollution and Alzheimer's Disease: From Epidemiological Facts to Molecular Mechanisms
https://pubmed.ncbi.nlm.nih.gov/29480184/
.....More recently, the potential deleterious effect of air pollution inhalation on the central nervous system was also investigated and mounting evidence supports a link between air pollution exposure and neurodegenerative pathologies, especially Alzheimer's disease (AD).
2023 Aug 10
Department of Neurology, Sichuan Taikang Hospital, Chengdu, Sichuan, China
Unraveling the link: exploring the causal relationship between diabetes, multiple sclerosis, migraine, and Alzheimer's disease through Mendelian randomization
https://pubmed.ncbi.nlm.nih.gov/37694124/
----------------------------------
O3
30 March 2023
The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
https://ehjournal.biomedcentral.com/art ... 23-00981-0
..Long-term exposure to ozone may increase the risk of T2D
----------------
Oct 7, 2019
Can Weather or Air Pollution Trigger Migraine?
https://www.news-medical.net/health/Can ... raine.aspx
...In addition, traffic-related pollutants, such as ozone precursors and carbon monoxide, are known to induce migraine headache, particularly in cold climates
---------------
2018
Université Claude Bernard Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Center, Lyon, France
Ozone Atmospheric Pollution and Alzheimer's Disease: From Epidemiological Facts to Molecular Mechanisms
https://pubmed.ncbi.nlm.nih.gov/29480184/
.....More recently, the potential deleterious effect of air pollution inhalation on the central nervous system was also investigated and mounting evidence supports a link between air pollution exposure and neurodegenerative pathologies, especially Alzheimer's disease (AD).
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Sep 6
Department of Respiratory Medicine, Traditional Chinese Medicine Hospital of Hebei Province, Shijiazhuang, People's Republic of China
Ozone Pollution and Acute Exacerbation of Asthma in Residents of China: An Ecological Study
https://pubmed.ncbi.nlm.nih.gov/37700876/
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MS
February 2019
Sciencedirec
Prevalence of asthma in multiple sclerosis: A United States population-based study
https://www.sciencedirect.com/science/a ... 4818305406
2023 Sep 6
Department of Respiratory Medicine, Traditional Chinese Medicine Hospital of Hebei Province, Shijiazhuang, People's Republic of China
Ozone Pollution and Acute Exacerbation of Asthma in Residents of China: An Ecological Study
https://pubmed.ncbi.nlm.nih.gov/37700876/
-----------------------------
MS
February 2019
Sciencedirec
Prevalence of asthma in multiple sclerosis: A United States population-based study
https://www.sciencedirect.com/science/a ... 4818305406
https://www.eboro.cz
Re: Tropospheric ozone
2023 Sep 7
School of Health and Environmental Science & Department of Health and Safety Convergence Science, Korea University , Republic of Korea
Visualizing indoor ozone exposures via o-dianisidine based colorimetric passive sampler
https://pubmed.ncbi.nlm.nih.gov/37703734/
School of Health and Environmental Science & Department of Health and Safety Convergence Science, Korea University , Republic of Korea
Visualizing indoor ozone exposures via o-dianisidine based colorimetric passive sampler
https://pubmed.ncbi.nlm.nih.gov/37703734/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2020 Jul
Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, Member DZL, German Center for Lung Research, Munich, Germany
Depression and anxiety with exposure to ozone and particulate matter: An epidemiological claims data analysis
https://pubmed.ncbi.nlm.nih.gov/32442925/
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MS
2023 Aug 29
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
The prevalence of major depression and generalized anxiety disorder in patients with multiple sclerosis in Saudi Arabia: a cross-sectional multicentered study
https://pubmed.ncbi.nlm.nih.gov/37706033/
2020 Jul
Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, Member DZL, German Center for Lung Research, Munich, Germany
Depression and anxiety with exposure to ozone and particulate matter: An epidemiological claims data analysis
https://pubmed.ncbi.nlm.nih.gov/32442925/
-------------------------------
MS
2023 Aug 29
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
The prevalence of major depression and generalized anxiety disorder in patients with multiple sclerosis in Saudi Arabia: a cross-sectional multicentered study
https://pubmed.ncbi.nlm.nih.gov/37706033/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Jul
Ozone Environmental Pollution: Relationship between the Intestine and Neurodegenerative Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376557/
----------------------------
MS
2023 Aug
Neurology Clinic Tsudanuma & Dowakai Chiba Hospital Funabashi, Japan
Gastrointestinal Dysfunction in Multiple Sclerosis and Related Conditions
https://pubmed.ncbi.nlm.nih.gov/37703888/
2023 Jul
Ozone Environmental Pollution: Relationship between the Intestine and Neurodegenerative Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376557/
----------------------------
MS
2023 Aug
Neurology Clinic Tsudanuma & Dowakai Chiba Hospital Funabashi, Japan
Gastrointestinal Dysfunction in Multiple Sclerosis and Related Conditions
https://pubmed.ncbi.nlm.nih.gov/37703888/
https://www.eboro.cz