I found some tests (the patent application) in the web for an interferon beta stabilization solution NEARLY the same as the new Rebif formulation (with polaxamer 188 and L-methionine) compared with the old formulation with serum albumin.
The experiments were about aggregat formation, oxidized forms, bioidentity etc. at different temperatures (4°C, 25°C, 40°C). There was not much a difference between the old and the new formulation at 25°C.
This is why I ignore the new storage conditions and if there is no fridge I keep my Rebif at room temperature for short time periods... But I do not guarantee for anything!!! Maybe its risky.
I also have a "Frio" pocket for insulin which cools with evaporation. You just need water.
I hope that was helpful,
This is very helpful. I'll try to get the insulin pack that you mentioned. My Rebif nurse didn't mention this. She just said to keep in a cooler bag with one of those special ice packs and change the pack every day.
Thank you. Lisbeth
Concerning Afrika: I made a test with the pocket in our 37°C-room (I work in a lab), and the temperature in the pocket was below 30°C, but not 25°C.
P.S. Celcius-Fahrenheit converter:
Thanks again. I guess after I do my first trip, I'll decide whether it's so inconvenient as to be impossible. If that's the case, I'll ask my neurologist about switching to Betaferon, which doesn't require any refrigeration at all. But maybe by then Serono will rewrite its refrigeration requirements!
You might also want to look into Avonex. The powdered form of Avonex can go 30 days at room temperature without refrigeration.Lisbeth wrote:Thanks again. I guess after I do my first trip, I'll decide whether it's so inconvenient as to be impossible. If that's the case, I'll ask my neurologist about switching to Betaferon, which doesn't require any refrigeration at all. But maybe by then Serono will rewrite its refrigeration requirements!
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When I first started Rebif two years ago my nurse told me it was ok to take an entire week of shots out of the fridge and leave them out. So apparently, short term lack of refigeration doesn't bother it. If your trips to Africa last a week or less the lack of refigeration might not be an issue. Definately ask your Rebif nurse about it.
For the last responses--Rebif New Formulation was approved in 2008. The earlier version can live outside of the refrigerator for up to 30 days. So I've been a happy user. Question is whether RNF can. I'm going to start out by following Sandrine's suggestions. Thank you again. Lisbeth
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