A board to discuss future MS therapies in early stage (Phase I or II) trials.
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Summary of the pipeline
Replies: 435
by
dignan » Tue Aug 02, 2005 10:55 am
First post
Here's a summary I just put together for myself that I thought I'd share. I've compiled all the substances I could find on the net currently in the...
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hi they stop it unless you want cancer bexarotene the one the other one it On going by 2025 we have this drugs in m.s
i use it now
- 435 Replies
- 183586 Views
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Last post by Weneedhope
Sun Dec 13, 2020 12:41 am
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Progressive MS Pipeline
Replies: 44
by
dignan » Mon Mar 24, 2008 5:12 pm
First post
Upon request, here are the drugs from the pipeline that are being tested for progressive forms of MS. If I've missed anything, please let me know....
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Relative risk reduction should be calculated as (controls-treated)/controls.
This yields (43%-36%)/43% = 16.3% relative risk reduction.
Am I...
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Last post by NHE
Fri Sep 27, 2019 5:35 pm
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MSRV Retrovirus, phase 2
Replies: 64
by
Fred1208 » Thu Dec 20, 2012 3:05 pm
First post
Hello everybody :smile:
I am involved in the following study, described hereafter.
Mister Hervé Perron, who found the retrovirus, gave more...
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Genuero Presentation: Defeating neurodegeneration through HERVs
April 2021
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Last post by Fred1208
Sat Apr 17, 2021 12:43 am
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- 2 Replies
- 482 Views
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Last post by NHE
Tue Mar 23, 2021 1:40 pm
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what dose fast track mean F.D.A it can help all
Replies: 5
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Weneedhope » Tue Dec 15, 2020 7:15 pm
First post
hi all when sould we see this drug ?
thank you
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Hi,
You might hear something about the phase 2 trials in about a years time. They will have to consider what they found then construct, recruit and...
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Last post by Scott1
Sat Feb 06, 2021 11:42 pm
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BioNTech MS vaccine
Replies: 10
by
81Charger » Wed Jan 13, 2021 5:27 am
First post
Just posting the link here. Has anyone else read this and what are your thoughts?
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i take it will take 7 years to past to m.s testing or any reply no this ?? or it faster
thank you
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- 936 Views
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Last post by Weneedhope
Sun Jan 24, 2021 8:13 pm
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- 7 Replies
- 1801 Views
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Last post by NHE
Tue Jan 12, 2021 12:15 pm
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fast track from fda not right place
Replies: 1
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Weneedhope » Mon Jan 11, 2021 8:13 pm
First post
it take time before we get it i hope i right place
thank you
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The experimental drug discussed in this article, ACE-1334, is for systemic sclerosis which is a lung disease. Unfortunately, it's not for multiple...
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- 205 Views
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Last post by NHE
Mon Jan 11, 2021 9:18 pm
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- 0 Replies
- 326 Views
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Last post by Petr75
Wed Jan 06, 2021 12:02 pm
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new Hope for all regenerativemedicine
Replies: 1
by
Weneedhope » Thu Dec 10, 2020 2:07 pm
First post
hi i am new here all i say the fda too slow for new drugs i say new hope be a start for all of us
and yes i look it up i none info here ? i look in...
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hi all with not a reply , i was in they podcast
if they get Phase 2 its done deal f.d.a speed it up will not need Phase 3
plus 10 years them in...
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- 501 Views
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Last post by Weneedhope
Fri Dec 25, 2020 5:30 pm
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Lovastatin and Rolipram
Replies: 2
by
scoobyjude » Fri Dec 19, 2008 7:51 pm
First post
Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple...
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2020 Aug 14
Department of Morphology and Animal Physiology, Federal Rural University of Pernambuco (UFRPE), Recife, Brazil
Lovastatin producing by...
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- 2132 Views
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Last post by Petr75
Sat Sep 12, 2020 8:46 am
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Monash University researchers one step closer to finding treatment
Replies: 3
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81Charger » Mon Feb 17, 2020 12:35 pm
First post
Australian researchers are one step closer to find a new treatment for multiple sclerosis (MS) that may be able to reverse the effects the disease...
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Oh look, they cured eae. Again. What is this, 300, 499 cures for mice. How many work on people? Oh, 0? Maybe they should look in a different...
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Last post by Anunymouse
Thu Aug 06, 2020 6:33 am
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Status of DMT as of Jan. 2020
Replies: 3
by
frodo » Thu Jan 09, 2020 4:08 am
I have tried to merge different sources from UK and the USA removing inconsistencies. Mainly wikipedia and
Though is not officially considered a...
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Last post by frodo
Fri Jul 24, 2020 12:40 am
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- 0 Replies
- 371 Views
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Last post by frodo
Mon Jul 13, 2020 8:16 am
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Could be this time?
Replies: 4
by
ton » Mon Mar 26, 2018 6:24 am
First post
The Black Swan we are waiting for?:
Last post
GeNeuro enrolls first patient in temelimab Phase 2 multiple sclerosis trial in collaboration with the Karolinska Institutet’s Academic Specialist...
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Last post by ton
Thu Jun 25, 2020 11:58 am
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Next DMTs to come
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frodo » Tue Jun 23, 2020 8:52 am
Ozanimod, laquinimod, BTK inhibitors (fenebrutinib, ibrutinib, and evobrutinib), Ibudilast, Lipoic acid and (maybe) Biotin.
Source:
Emerging...
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- 269 Views
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Last post by frodo
Tue Jun 23, 2020 8:52 am
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- 2 Replies
- 1785 Views
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Last post by Anunymouse
Wed Jun 17, 2020 8:51 am
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Masitinib for PP/SP MS
Replies: 2
by
zen2010 » Thu Feb 20, 2020 12:31 pm
First post
AB Science Announces Positive Phase 2B / 3 Results for Masitinib in Progressive Forms of Multiple Sclerosis
Masitinib significantly slows the...
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Full results of phase 2B/3 were presented and discussed yesterday during a webconf:
▪ Masitinib significantly delays disability progression...
- 2 Replies
- 1745 Views
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Last post by zen2010
Fri Mar 06, 2020 11:37 pm
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NEED HELP
Replies: 2
by
seeva » Sun Apr 16, 2017 3:03 am
First post
HI Friends I need a help
my m.s friend told me that recenly in AUSTRALIAN TV CHANNELS a news about a new drug for m.s which
can improved a lady's m.s...
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Dear friend the m.s man mention that he used medical cannabis oil injection
Thanks
Seeva
- 2 Replies
- 3154 Views
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Last post by seeva
Tue Feb 04, 2020 2:33 am
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- 0 Replies
- 870 Views
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Last post by frodo
Fri Jan 17, 2020 2:54 am
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- 0 Replies
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Last post by CureOrBust
Sun Sep 22, 2019 6:01 am
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Temelimab safe even high dose
by
frodo » Thu Jul 18, 2019 3:41 am
A High-dose Pharmacokinetic Study of a New IgG4 Monoclonal Antibody Temelimab/GNbAC1 Antagonist of an Endogenous Retroviral Protein pHERV-W Env...
- 0 Replies
- 1597 Views
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Last post by frodo
Thu Jul 18, 2019 3:41 am
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Depleting EBV infected b-cells therapy
Replies: 2
by
frodo » Sun Mar 17, 2019 6:44 am
First post
Depleting EBV with artificial T-cells works, even in progressive stage.
Epstein-Barr virus–specific T cell therapy for progressive multiple...
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I wonder if someone on this forum have had this treatment? Did it work? Are there private clinics in USA or elsewhere that would offer this...
- 2 Replies
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Last post by frodo
Thu Jul 04, 2019 4:14 am
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RE:CLADRINE APPROVED BY FDA FOR SPM
Replies: 1
by
seeva » Thu Jun 13, 2019 12:40 am
First post
HI friends
very good news that medication CLADRINE ALSSO CALLED MAVENCLAD approved by FDA for treatment of
Secondary Progressive M.S. this edition...
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Cladribine has an FDA black box warning that it increases cancer risk. Buyer beware.
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- 1265 Views
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Last post by NHE
Thu Jun 13, 2019 12:54 am
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Biotin. Good results in progressive MS
by
frodo » Thu Apr 25, 2019 5:08 am
Effect of MD1003 (high dose Pharmaceutical grade Biotin) in the Treatment of Progressive MS: Earlier Treatment Results in Lower Disability Over 48...
- 0 Replies
- 2168 Views
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Last post by frodo
Thu Apr 25, 2019 5:08 am
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Siponimod approved by FDA
by
frodo » Tue Apr 23, 2019 3:18 am
Maybe we should make a new thread?
FDA approves new oral drug to treat multiple sclerosis in the US
The US Food and Drug Administration has...
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Last post by frodo
Tue Apr 23, 2019 3:18 am
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from MSUK: Temelimab passes phase IIb
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frodo » Mon Apr 22, 2019 10:23 am
Temelimab is the only drug under research that targets a viral protein, and probably the only one that targets the underlying cause of MS....
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- 1181 Views
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Last post by frodo
Mon Apr 22, 2019 10:23 am
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- 0 Replies
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Last post by frodo
Mon Apr 22, 2019 10:19 am
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Drug effectiveness in doubt.
Replies: 6
by
vesta » Sun Oct 26, 2014 2:32 am
First post
On March 21, 2013 it was announced that Professor George C. Ebers, MD, of University of Oxford in London, had been chosen to receive the National MS...
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hi,
here is an interesting link:
- 6 Replies
- 3592 Views
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Last post by zen2010
Sun Mar 10, 2019 4:56 am
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Ublituximab Phase II Success
Replies: 2
by
NHE » Thu Mar 07, 2019 5:10 pm
First post
Ublituximab targets CD20 and depletes B cells. Researchers report that their phase II study was successful.
Last post
Thks for the info.
It looks like Rituxan or Ocrevus (Anti- CD20 antibodies).
It's for both RR and PP.
- 2 Replies
- 1360 Views
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Last post by zen2010
Fri Mar 08, 2019 1:17 am
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- 0 Replies
- 2063 Views
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Last post by frodo
Sun Dec 23, 2018 2:05 am
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- 0 Replies
- 1863 Views
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Last post by frodo
Fri Dec 21, 2018 6:16 am
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- 0 Replies
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Last post by seeva
Fri Nov 23, 2018 3:03 am
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The Misfortune of MS Drugs
Replies: 6
by
vesta » Wed Mar 21, 2018 3:41 am
First post
THE MISFORTUNE OF MS DRUGS
We have a situation where drug research has restricted itself to
suppressing the immune system reaction. No effort is...
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Nicotinic acid in high doses
- 6 Replies
- 3284 Views
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Last post by Kheuer
Wed Nov 21, 2018 5:35 pm
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Ibudilast phase II successful
Replies: 1
by
NHE » Fri Aug 31, 2018 3:39 pm
First post
Phase 2 Clinical Trial of Oral Ibudilast Demonstrates Slowing of Brain Atrophy in Progressive MS
August 29, 2018
SUMMARY
Results were...
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Regarding Lipoic Acid...
These are high doses. And while it seems safe, we won't know whether it actually improves the lives of people with MS...
- 1 Replies
- 2512 Views
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Last post by Zyklon
Sat Sep 01, 2018 9:24 am
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DR.SU METALFE'S COMPANY COULD BE ON THE VERGE OF CURING M.S
Replies: 3
by
seeva » Tue Jul 03, 2018 10:58 pm
First post
Dear friends please read
Dr.Sumetalfe's company LiFNano could be on the verge of curing M.S
Regards
Seeva
Last post
They dont know what MS is. They do not know either why it appears. They cannot be sure about diagnosis excep after an autopsy.
But they claim to...
- 3 Replies
- 2568 Views
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Last post by frodo
Thu Jul 26, 2018 8:42 am
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- 0 Replies
- 2251 Views
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Last post by seeva
Tue Jun 19, 2018 3:01 am
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Has anyone here had BOTOX injections in the bladder ?
Replies: 27
by
dc10 » Thu Feb 07, 2013 1:09 pm
First post
a uro-neurologist has offered me this treatment option of having BOTOX injections in the bladder to improve bladder incontinence symptoms,
he said it...
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With time, I seem to be getting less of a benefit with botox injections for neurogenic bladder. When I first started 5 years ago, the benefit I...
- 27 Replies
- 19860 Views
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Last post by Quest56
Mon Jun 11, 2018 10:14 am
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- 0 Replies
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Last post by CureOrBust
Mon May 28, 2018 1:10 am
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Disease modifying therapies - POLL
Replies: 4
by
carpediem » Fri May 04, 2018 9:13 am
First post
Hello everyone!
I am new here. I'm trying to decide between all these different disease modifying therapies. I'm curious to see which one worked...
Last post
Glad to...
Here is a summary of what I follow:
High good fat diet, virtually no vegetables or fruits or carbs. (Vegetables in very small quantities...
- 4 Replies
- 2687 Views
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Last post by ElliotB
Mon May 07, 2018 8:47 am
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Carlos: MS & FMT Treatment
by
seeva » Tue May 01, 2018 11:29 pm
HI FRIENDS GOOD INFO PLEASE READ
Meet Carlos, he was diagnosed with MS (Multiple sclerosis). He tells his story & his journey with FMT and how he...
- 0 Replies
- 2940 Views
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Last post by seeva
Tue May 01, 2018 11:29 pm
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BOTOX injections against adductor spasms in the legs?
Replies: 1
by
UWE59 » Sun Apr 01, 2018 4:13 am
First post
Does anybody had BOTOX injections against adductor spasms in the legs?
Regards
Uwe
Last post
Hi,
I had a total of 9 botox injections in my left leg to deal with quite a number of spasticity issues. The adductors are on the inside of the...
- 1 Replies
- 2579 Views
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Last post by Scott1
Sun Apr 01, 2018 4:58 am
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4-aminopyridine-3-methyl hydroxide
Replies: 22
by
Ned » Tue Apr 20, 2010 5:02 am
First post
I had been taking 4-aminopyridine, and was having trouble stabilising on a suitable dose for me, due to side effects.
I had very good results taking...
Last post
Anybody has good results with 4-aminopyridine-3-methyl hydroxide?
Where I can buy it? (To buid capsula is no Problem for me)
Regards
Uwe
- 22 Replies
- 16799 Views
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Last post by UWE59
Sun Apr 01, 2018 4:00 am
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Roche's New MS Drug Set For Early FDA Approval
Replies: 2
by
seeva » Sun Jan 28, 2018 4:45 am
First post
HI FRIENDS PLEASE READ
Roche’s new multiple sclerosis drug Ocrevus set for early FDA approval
regards
seeva
Last post
HI FRIENDS PLEASE READ
Roche’s new multiple sclerosis drug Ocrevus set for early FDA approval
regards
seeva
Article date: Jun 28, 2016
- 2 Replies
- 3312 Views
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Last post by NHE
Fri Feb 02, 2018 9:27 pm
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RE:CLEMASTINE FUMARATE MAY REPAIR MYELIN IN PWMS
Replies: 1
by
seeva » Mon Nov 20, 2017 12:58 am
First post
Hi Friends please read
regards
seeva
Last post
Just take plain fumaric acid which is on ebay cheap as chips. Or amazon or a food ingredient supplier (it is E297). The phospholipids in soy lecithin...
- 1 Replies
- 3258 Views
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Last post by sam112233
Wed Dec 13, 2017 12:30 am
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Over-the-counter antihistamine, Tavist, being tested
Replies: 10
by
vw35qrt » Sat Jul 19, 2014 6:27 pm
First post
Is anyone taking this over the counter antihistamine and seeing any improvement in their symptoms?
Last post
So..we now have results of this test out...any opinions?
Can you share a link to those results please?
Try this:
I wonder: So 50 patients...
- 10 Replies
- 6629 Views
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Last post by Marc70
Fri Oct 20, 2017 1:13 pm
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Low Cost High Dose Biotin
Replies: 3
by
ElliotB » Wed Sep 20, 2017 4:00 pm
First post
I have been taking Biotin for years, and for most of that time I have been using Pharmaceutical Grade Biotin Powder (significantly less expensive)....
Last post
Wow! Great deal!!
- 3 Replies
- 3407 Views
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Last post by ElliotB
Sun Sep 24, 2017 4:16 am
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MedDay’s Phase 3 Trial - impact on Optic Neuritis failed
Replies: 1
by
ElliotB » Wed Sep 20, 2017 3:40 pm
First post
I just saw this even though it is from a few months ago - hope it is not a duplication on TIMS.
MedDay’s MD-1003 PHASE III Optic Neuritis Trial...
Last post
Dude,
Where do you get your stuff from? This is like 1 1/2 years old....
- 1 Replies
- 2605 Views
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Last post by Marc70
Thu Sep 21, 2017 11:24 am
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LIF Therapy. Possible cure?
Replies: 2
by
MSKarateka » Sun Jun 25, 2017 8:40 am
First post
scientist-cambridge-university-may-found-cure-multiple-sclerosis
Your thoughts would be interesting.
Last post
I'm sure it will help the mice. It must be awesome to be a lab mouse, everything cures you.
- 2 Replies
- 3193 Views
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Last post by Anunymouse
Wed Sep 20, 2017 12:25 pm
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- 0 Replies
- 2946 Views
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Last post by seeva
Tue Jun 13, 2017 2:17 am
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