A forum to discuss research on the origins of MS and its development.
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EBV-infected B-cells? We will have an answer soon
Replies: 4
by
frodo » Sun Apr 16, 2017 9:44 am
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This post is about a clinical trial, but I post it here before it will yield the answer to the new MS model.
Some time ago, MS was considered an...
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Would another viral infection causes the EBV to re-activate,?
I read that lack of oxygen could cause EBV to re-activate. Couldn't poor blood...
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Last post by frodo
Mon Jul 31, 2017 2:21 am
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MS and EBV relapse together
Replies: 4
by
frodo » Sun Apr 16, 2017 4:13 am
First post
This article is 4 years old but I found it interesting
Multiple Sclerosis and EBV: Relapsing Together
The activity of the Epstein-Barr virus in the...
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Also interesting:
The beneficial effects of vitamin D3 on reducing antibody titers against Epstein-Barr virus in multiple sclerosis patients ....
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Last post by frodo
Mon Jul 24, 2017 12:03 am
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MS B-cells secretory products are toxic
Replies: 2
by
frodo » Sun May 14, 2017 9:16 am
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B-cells again pointed as the culprit in MS.
Of course this does not exclude any other research way (clamidia? ccsvi? iron? guts?). All can be...
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And there is another similar report:
Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro
Abstract
B...
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Last post by frodo
Thu Jul 13, 2017 1:13 am
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Neonatal vitamin D status and risk of multiple sclerosis
Replies: 1
by
NHE » Mon Jul 03, 2017 3:50 am
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Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study.
Neurology. 2017 Jan 3;88(1):44-51.
OBJECTIVE:...
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Very interesting. Thank you.
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- 797 Views
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Last post by frodo
Tue Jul 04, 2017 5:53 am
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new medical entity set appart from MS
by
frodo » Mon Jun 26, 2017 2:28 pm
First it was Neuromyelitis Optica . It was set appart from MS when anti-AQP4 antibodies were found to be specific of this kind of disease.
Then it...
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Last post by frodo
Mon Jun 26, 2017 2:28 pm
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Lipid metabolism linked to MS
Replies: 1
by
frodo » Tue Jun 13, 2017 1:50 pm
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The use of vibrational spectroscopy to study the pathogenesis multiple sclerosis and similar neurological conditions
They say more or less that...
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Related to this, anti-acne medications has an effect
Acne drug slows MS development
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- 845 Views
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Last post by frodo
Wed Jun 21, 2017 7:35 am
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New model of MS: Response against infected B-Cells
Replies: 5
by
frodo » Mon Mar 27, 2017 3:15 am
First post
A recent failure with Tysabri has shed some light into MS pathogenesis. It seems that is not EBV itself, but some B-cells infected by EBV, the cause...
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More evidence about the EBV-infected b-cells theory:
Half of progressive MS patients treated with Epstein-Barr virus sensitised T-cells see symptom...
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- 1185 Views
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Last post by frodo
Wed Jun 21, 2017 6:37 am
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Last post by MSUK
Tue Jun 20, 2017 5:22 am
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Last post by frodo
Sat Jun 17, 2017 6:19 am
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new biomarkers of disease progression linked to cholesterol
Replies: 2
by
frodo » Wed May 17, 2017 11:34 pm
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It seems that the Simvastatin connection is under research by the groups that investigate pathogenesis, and they have found that some...
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More about biomarkers
Source:
... We developed in a training cohort ... two biomarker-based classifiers that differentiate:
1. MS from CNS...
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- 1095 Views
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Last post by frodo
Sat Jun 17, 2017 6:06 am
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specific auto-antibodies in blood
Replies: 2
by
frodo » Mon May 22, 2017 9:58 am
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Researchers have found different auto-antibodies markers in blood in SPMS and RRMS. These different biomarkers could shed light into the...
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More about blood tests. Morphogenetic proteins are required to grow stem cells into their final form, in this case, neurons and oligodendrocytes....
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- 844 Views
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Last post by frodo
Tue Jun 06, 2017 12:03 am
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Rab32 connects ER stress to mitochondrial defects in MS
Replies: 2
by
NHE » Tue Apr 25, 2017 3:25 am
First post
Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.
J Neuroinflammation. 2017 Jan 23;14(1):19.
BACKGROUND: Endoplasmic...
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You are lots more scientific than I. All I know is my doctor told me a lot about hyperbaric oxygen chambers helping regenerate mitochondrial DNA in...
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- 898 Views
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Last post by violin
Tue May 09, 2017 9:38 pm
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mitochondrial Rab32 involved
by
frodo » Tue May 09, 2017 8:36 am
Rab32 is a protein involved in mitochondrial stress. It has been found to be present in MS lesions and now it has been found to be specific of MS...
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- 731 Views
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Last post by frodo
Tue May 09, 2017 8:36 am
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- 727 Views
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Last post by frodo
Mon May 08, 2017 12:51 am
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Last post by frodo
Sun May 07, 2017 10:44 pm
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MS: A Functional Disorder
Replies: 13
by
vesta » Tue Apr 26, 2016 2:41 am
First post
MULTIPLE SCLEROSIS: A FUNCTIONAL DISORDER
If I had known that Multiple Sclerosis is essentially a problem of fluid circulation (blood,...
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Hi Vesta
Congratulations for your brilliant and clear explanation about this complex desease. I agree with most of your points of view. You have...
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- 1982 Views
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Last post by vesta
Sun May 07, 2017 9:01 am
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whatever Rituxan does, it does it outside the CNS
Replies: 1
by
frodo » Sat Apr 29, 2017 3:36 am
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Whatever Rituxan does, it does it outside the CNS. PET imaging shows that Rituxan never enters the CNS at all. This leaves open the question about...
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Hi,
That raises the intriguing idea of EBV infection. Latent EBV resides in the B cell so if you ablate to B cell you remove the EBV.
He mentions...
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- 728 Views
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Last post by Scott1
Sat Apr 29, 2017 10:03 pm
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meningeal inflammation in early multiple sclerosis
Replies: 2
by
frodo » Sat Apr 22, 2017 11:14 am
First post
Whatever MS is, meningeal inflammation (and therefore gray matter damage) is present since the beginning.
Source:
Results:
A para-sulcal CL was...
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Hi,
It may be too selective to just focus on meninges. They are just a part of a broader group of connective tissue called fascia. Varieties of...
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- 795 Views
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Last post by Scott1
Sun Apr 23, 2017 4:18 am
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To boost or supress autoimmunity, that is the question
Replies: 4
by
MSUK » Thu Sep 11, 2014 12:27 am
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Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation....
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If you look at the CPn (or even MAP) thesis, it is a very simple explanation indeed.
Dr Wheldon points to EBV, HHV-6 and potentially other viral...
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- 1511 Views
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Last post by SeanReynolds
Wed Apr 19, 2017 6:30 pm
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Some forms of MS are inherited
Replies: 3
by
frodo » Wed Apr 19, 2017 2:24 am
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Maybe EBV-infection is required to develop MS but a lot of people with EBV do not develop MS. There must be something more.
Some forms of MS could...
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Once again, reading that Canadian/Australian research, the findings are completely consonant with acquiring a CPn type infection at some stage in the...
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- 691 Views
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Last post by SeanReynolds
Wed Apr 19, 2017 6:18 pm
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The old posts of Leonard
Replies: 1
by
frodo » Sat Apr 15, 2017 2:42 am
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I have just stumbled upon some old post of Leonard. They are long but they contain a lot of information. I think that in a forum about etiology they...
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Interesting reading about the EBV thesis.
I'm trying to see a connection with the CPn thesis, Dr Wheldon does point to a cumulative immune effect...
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- 723 Views
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Last post by SeanReynolds
Tue Apr 18, 2017 12:14 am
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Is there a pulse wave encephalopathy component to MS?
Replies: 2
by
NZer1 » Fri Mar 17, 2017 11:34 pm
First post
Is there a pulse wave encephalopathy component to multiple sclerosis?
Juurlink BH1.
Abstract
The dominant hypothesis in multiple sclerosis is that it...
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The CPn/MAP thesis of a bacterial cause of MS resolves this puzzle completely.
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- 875 Views
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Last post by SeanReynolds
Fri Apr 14, 2017 8:51 pm
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Research breathes new life into MS viral theory
Replies: 4
by
MSUK » Thu Feb 12, 2015 5:38 am
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Research breathes new life into theory supporting possible viral etiology of multiple sclerosis
Several clusters of multiple sclerosis cases have...
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Some have suggested Chlamydophila pneumoniae is the cause of MS, also pointing to the Faroe Islands case.
Easily spread by close contact.
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- 1460 Views
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Last post by SeanReynolds
Fri Apr 14, 2017 8:34 pm
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Last post by frodo
Mon Apr 03, 2017 11:55 pm
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MRZ Reaction as biomarker
by
frodo » Mon Mar 27, 2017 4:24 am
It seems that to have antibodies at the same time against Measles, Rubella and Varizella-Zoster viruses (MRZ viruses) is highly specific for MS (97%...
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- 819 Views
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Last post by frodo
Mon Mar 27, 2017 4:24 am
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Last post by jimmylegs
Thu Nov 05, 2015 5:24 pm
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CNS lymph vessels found. Brain is not immune-privileged
Replies: 59
by
cheerleader » Mon Jun 15, 2015 9:03 am
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(edit) New discovery from 2 separate universities is changing medical textbooks and MS research.
The brain is not immune-privileged, as postulated...
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If the lymph is part of the response to inflammation then shouldn't adopting an anti-inflammatory diet and using appropriate anti-inflammatory...
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- 8059 Views
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Last post by cheerleader
Mon Aug 31, 2015 5:24 am
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Last post by MSUK
Tue Sep 02, 2014 3:04 am
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Some Interesting Connections
Replies: 156
by
Annesse » Tue Aug 06, 2013 7:03 pm
First post
I was doing some research and think I may have stumbled on a few interesting connections.
As some of you know, I believe that MS originates with a...
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Hi cervocuit~
Protease and DNase 1 originate in the exocrine pancreas. Your body makes your enzymes, which are proteins, just like it makes all of...
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- 21568 Views
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Last post by Annesse
Sat Feb 01, 2014 12:34 pm
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Last post by tzootsi
Tue Nov 05, 2013 5:24 pm
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MS, ebv, hygiene increase together in Mexico City (study)
Replies: 1
by
Anonymoose » Sun Sep 01, 2013 2:18 pm
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High anti-EBNA1 antibody titers appears to be associated with increased MS risk even in a region where MS had historically low incidence and...
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The finding of moderate support for a role of higher ‘hygiene’ being associated with susceptibility to MS, could signify decreased vitamin D levels...
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- 1301 Views
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Last post by grandsons4
Sun Sep 01, 2013 2:56 pm
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Iron and neurodegeneration in the multiple sclerosis brain
Replies: 7
by
MSUK » Thu Aug 01, 2013 1:34 am
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This study looked at the distribution of non-heme iron as well as the expression of the iron-related proteins ferritin, hephaestin and ceruloplasmin...
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Dr. Geoff--Welcome. I'm sorry your MS has progressed so quickly. What causes MS? That's still unknown. But these studies are really important,...
- 7 Replies
- 2022 Views
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Last post by cheerleader
Mon Aug 05, 2013 9:26 am
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