MS Etiology and Pathogenesis

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More about EBV involvement

Last post by frodo « Mon Nov 06, 2017 10:58 am

by frodo » Mon Nov 06, 2017 10:58 am

This study points to a low response against EBV in MS patients. Maybe the immune system in MS is unable to control EBV properly.

Low intrathecal...

0 Replies

823 Views

Last post by frodo
Mon Nov 06, 2017 10:58 am
review about body fluid biomarkers

Last post by frodo « Fri Nov 03, 2017 10:44 am

by frodo » Fri Nov 03, 2017 10:44 am

Source:

Fluid biomarkers for microglial activation and axonal injury in multiple sclerosis

Abstract

Although it is clear that the immune system...

0 Replies

845 Views

Last post by frodo
Fri Nov 03, 2017 10:44 am
more evidence against the autoimmune model

Last post by frodo « Mon Oct 23, 2017 6:34 am
Replies: 2
by frodo » Tue Aug 01, 2017 11:28 pm

First post

This article is a PDF that you can download:

Pathogenesis of Multiple Sclerosis: How Much Space is Left for Autoimmunity?

Abstract

Multiple...

Last post

More voices against the autoimmune model:

Source:

Abstract:

The inflammatory demyelinating lesions that are characteristic of multiple sclerosis...

2 Replies

1244 Views

Last post by frodo
Mon Oct 23, 2017 6:34 am
Neurofilament light chains (NFL)

Last post by frodo « Sun Oct 22, 2017 11:35 pm

by frodo » Sun Oct 22, 2017 11:35 pm

In the search of a body fluid biomarker for MS, currently the main candidate are neurofilament light chains (NFL). They are short pieces of neurons...

0 Replies

749 Views

Last post by frodo
Sun Oct 22, 2017 11:35 pm
MS is not a single disease. It is four at least.

Last post by frodo « Sun Oct 22, 2017 11:10 pm
Replies: 5
by frodo » Wed Sep 06, 2017 2:37 pm

First post

MS was defined in the XIX century as the presence of scars in the brain. They didn't know what was causing them, and they still don't know. There is...

Last post

But a bigger question is; can they cure any of them?

That's just a secondary question. The main questions are, what the hell are they? why they do...

5 Replies

1313 Views

Last post by frodo
Sun Oct 22, 2017 11:10 pm
About the lesion's evolution

Last post by frodo « Mon Oct 16, 2017 12:29 am
Replies: 4
by frodo » Thu May 25, 2017 12:12 am

First post

The first damage that appears in white matter are the so-called normal appearing white matter (NAWM) areas. Myelin at these areas is already damaged,...

Last post

About the early events in the demyelination process, it seems that axonal pathology is independent from inflammation:

In vivo characterization of...

4 Replies

1116 Views

Last post by frodo
Mon Oct 16, 2017 12:29 am
MS also affects peripheral nervous system

Last post by frodo « Mon Oct 16, 2017 12:23 am

by frodo » Mon Oct 16, 2017 12:23 am

MRN - Magnetic resonance neurography - shows damage in peripheral nerves of MS patients. This is not explained by any of the currently accepted...

0 Replies

737 Views

Last post by frodo
Mon Oct 16, 2017 12:23 am
New association of vein anomalies and MS found

Last post by frodo « Thu Oct 05, 2017 11:47 am

by frodo » Thu Oct 05, 2017 11:47 am

New association of vein anomalies and MS found on Sept. 2017. I remark the date because this has been reported already before several times

I would...

0 Replies

869 Views

Last post by frodo
Thu Oct 05, 2017 11:47 am
Study identifies biomarker for the onset & progression of MS

Last post by frodo « Wed Oct 04, 2017 12:25 pm
Replies: 1
by MSUK » Wed Sep 27, 2017 3:04 am

First post

A team of researchers have identified Opioid Growth Factor (OGF) as a novel biomarker for the onset and progression of multiple sclerosis (MS)...Read...

Last post

A team of researchers have identified Opioid Growth Factor (OGF) as a novel biomarker for the onset and progression of multiple sclerosis (MS)...Read...

1 Replies

924 Views

Last post by frodo
Wed Oct 04, 2017 12:25 pm
A review about mechanisms in PPMS

Last post by frodo « Wed Oct 04, 2017 12:24 pm

by frodo » Wed Oct 04, 2017 12:24 pm

Abstract

Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple...

0 Replies

800 Views

Last post by frodo
Wed Oct 04, 2017 12:24 pm
more evidence about EBV: microRNAs

Last post by frodo « Sat Sep 23, 2017 11:34 am

by frodo » Sat Sep 23, 2017 11:34 am

Maybe closer to an explanation for MS, and also closer to a blood test.

The identification of up-regulated ebv-miR-BHRF1-2-5p targeting MALT1 and...

0 Replies

966 Views

Last post by frodo
Sat Sep 23, 2017 11:34 am
change to SPMS could be prevented

Last post by frodo « Thu Sep 21, 2017 7:39 pm

by frodo » Thu Sep 21, 2017 7:39 pm

MIF and D-DT are potential disease severity modifiers in male MS subjects

Source:

Abstract

Little is known about mechanisms that drive the...

0 Replies

878 Views

Last post by frodo
Thu Sep 21, 2017 7:39 pm
Biomarkers for response to therapies

Last post by frodo « Tue Sep 19, 2017 1:48 am
Replies: 1
by frodo » Tue Sep 19, 2017 1:45 am

First post

Having several disease modifying drugs available, is interesting to know what kind of response is expected for each one of the different drugs in a...

Last post

And here there is a review summarising the complete situation as of 2015

Conclusions:

A lack of understanding of the cause of MS, as well as...

1 Replies

913 Views

Last post by frodo
Tue Sep 19, 2017 1:48 am
microRNA miR-155 dysregulation

Last post by frodo « Tue Sep 19, 2017 1:38 am

by frodo » Tue Sep 19, 2017 1:38 am

Authors of the article say that is not only a biomarker, but also a target for intervention. I put it here in biomarkers just to be conservative....

0 Replies

786 Views

Last post by frodo
Tue Sep 19, 2017 1:38 am
Biomarkers for diagnosis thread

Last post by frodo « Tue Sep 19, 2017 1:31 am
Replies: 14
by frodo » Sun Jul 09, 2017 4:55 am

First post

Hi all,

Biomarkers can be used not only as a diagnosis, but also as a window to the underlying pathology. Therefore I start this thread about...

Last post

Optical tomography recommended as biomarker

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.
Source:...

14 Replies

1613 Views

Last post by frodo
Tue Sep 19, 2017 1:31 am
A review of PET in MS

Last post by frodo « Fri Sep 15, 2017 6:51 am

by frodo » Fri Sep 15, 2017 6:51 am

Positron emision tomography (PET) can show things that cannot be seen under MRI. Specially interesting is that microglia, some inmune cells of the...

0 Replies

887 Views

Last post by frodo
Fri Sep 15, 2017 6:51 am
An ancestral retroviral protein identified in diabetes

Last post by frodo « Sun Sep 10, 2017 9:06 am

by frodo » Sun Sep 10, 2017 9:06 am

I post this here knowing that MS and diabetes have probably very little in common, but given that HERVs are associated to MS, we could have a similar...

0 Replies

839 Views

Last post by frodo
Sun Sep 10, 2017 9:06 am
How MS Progresses

Last post by TeresaL « Mon Sep 04, 2017 1:35 pm
Replies: 5
by vesta » Tue Apr 04, 2017 2:23 am

First post

HOW MS PROGRESSES

The French Neurologist Jean-Martin Charcot, practicing at the Parisian la Pitié-Salpetrière hospital, first described Multiple...

Last post

CCSVI helped me but improvements didn't last long, Dr Siskin out in stents that clotted within 6mos. I was taking plavix also.

5 Replies

1254 Views

Last post by TeresaL
Mon Sep 04, 2017 1:35 pm
Nitric oxide may induce mitochondrial dysfunction of oligode

Last post by Scott1 « Tue Aug 22, 2017 2:09 am
Replies: 1
by frodo » Tue Aug 22, 2017 1:14 am

First post

Insights in pathogenesis of multiple sclerosis: nitric oxide may induce mitochondrial dysfunction of oligodendrocytes.

Abstract

Demyelinating...

Last post

Hi,

Be careful about what you read into this. The 1998 Nobel prize was awarded to three men for their work on Nitric Oxide. see It wasn't described...

1 Replies

914 Views

Last post by Scott1
Tue Aug 22, 2017 2:09 am
Biomarkers for response to therapy thread

Last post by frodo « Wed Aug 16, 2017 12:13 am

by frodo » Wed Aug 16, 2017 12:13 am

Besides the biomarkers for diagnosis there are also biomarkers that can predict the response to an specific therapy. They can also shed some light...

0 Replies

1012 Views

Last post by frodo
Wed Aug 16, 2017 12:13 am
PPMS specific pathology thread

Last post by frodo « Tue Aug 15, 2017 11:23 pm
Replies: 2
by frodo » Fri Aug 11, 2017 12:49 am

First post

For some things PPMS is different to normal MS. This is just the last one reported.

The relationship between cortical lesions and periventricular...

Last post

This is a long text about PPMS pathogenesis. It could be interesting.

Pathology and Pathogenesis of Progressive Multiple Sclerosis: Concepts and...

2 Replies

987 Views

Last post by frodo
Tue Aug 15, 2017 11:23 pm
MS is due to a bacteria that produce adenosylcobalamin

Last post by frodo « Tue Aug 15, 2017 11:12 pm

by frodo » Tue Aug 15, 2017 11:12 pm

This is a novel hypothesis for MS pathogenesis that the authors have called multiple sclerosis due to adenosylcobalamin deficiency . I really do not...

0 Replies

883 Views

Last post by frodo
Tue Aug 15, 2017 11:12 pm
what we know about MS as of 2017

Last post by frodo « Sun Aug 13, 2017 1:22 pm

by frodo » Sun Aug 13, 2017 1:22 pm

This is a copy of another post of Leonard. I copy and paste here to have all the references in this subforum

Source:

The causes and very...

0 Replies

1130 Views

Last post by frodo
Sun Aug 13, 2017 1:22 pm
Molecular mimicry?

Last post by frodo « Mon Aug 07, 2017 1:15 am

by frodo » Mon Aug 07, 2017 1:15 am

A new report that brings molecular mimicry again into the research field. In this case, they report that two proteins of the EBV virus could trigger...

0 Replies

845 Views

Last post by frodo
Mon Aug 07, 2017 1:15 am
Genetic link to vitamin D & MS

Last post by NHE « Sun Aug 06, 2017 2:13 am
Replies: 1
by tzootsi » Sat Aug 05, 2017 7:48 am

First post

Haven't had a chance to decipher this yet, but looks very interesting.

Last post

Thanks for posting this. Here's the abstract.

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of...

1 Replies

978 Views

Last post by NHE
Sun Aug 06, 2017 2:13 am
CSF from MS patients is toxic to neurons

Last post by frodo « Sat Aug 05, 2017 4:23 am

by frodo » Sat Aug 05, 2017 4:23 am

There are several reports about toxicity of CSF in MS patients. This is just the last one.

Bioenergetic Failure in Rat Oligodendrocyte Progenitor...

0 Replies

930 Views

Last post by frodo
Sat Aug 05, 2017 4:23 am
Ineffective immune control of EBV may cause exacerbation

Last post by frodo « Thu Aug 03, 2017 1:48 am

by frodo » Thu Aug 03, 2017 1:48 am

Ineffective immune control of EBV may cause exacerbation . That is the conclusion of this study, in which they say that normal CD8+ T-cells are able...

0 Replies

863 Views

Last post by frodo
Thu Aug 03, 2017 1:48 am
EBV-infected B-cells? We will have an answer soon

Last post by frodo « Mon Jul 31, 2017 2:21 am
Replies: 4
by frodo » Sun Apr 16, 2017 9:44 am

First post

This post is about a clinical trial, but I post it here before it will yield the answer to the new MS model.

Some time ago, MS was considered an...

Last post

Would another viral infection causes the EBV to re-activate,?
I read that lack of oxygen could cause EBV to re-activate. Couldn't poor blood...

4 Replies

1085 Views

Last post by frodo
Mon Jul 31, 2017 2:21 am
MS and EBV relapse together

Last post by frodo « Mon Jul 24, 2017 12:03 am
Replies: 4
by frodo » Sun Apr 16, 2017 4:13 am

First post

This article is 4 years old but I found it interesting

Multiple Sclerosis and EBV: Relapsing Together
The activity of the Epstein-Barr virus in the...

Last post

Also interesting:

The beneficial effects of vitamin D3 on reducing antibody titers against Epstein-Barr virus in multiple sclerosis patients ....

4 Replies

954 Views

Last post by frodo
Mon Jul 24, 2017 12:03 am
MS B-cells secretory products are toxic

Last post by frodo « Thu Jul 13, 2017 1:13 am
Replies: 2
by frodo » Sun May 14, 2017 9:16 am

First post

B-cells again pointed as the culprit in MS.

Of course this does not exclude any other research way (clamidia? ccsvi? iron? guts?). All can be...

Last post

And there is another similar report:

Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro

Abstract

B...

2 Replies

964 Views

Last post by frodo
Thu Jul 13, 2017 1:13 am
Neonatal vitamin D status and risk of multiple sclerosis

Last post by frodo « Tue Jul 04, 2017 5:53 am
Replies: 1
by NHE » Mon Jul 03, 2017 3:50 am

First post

Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study.
Neurology. 2017 Jan 3;88(1):44-51.

OBJECTIVE:...

Last post

Very interesting. Thank you.

1 Replies

826 Views

Last post by frodo
Tue Jul 04, 2017 5:53 am
new medical entity set appart from MS

Last post by frodo « Mon Jun 26, 2017 2:28 pm

by frodo » Mon Jun 26, 2017 2:28 pm

First it was Neuromyelitis Optica . It was set appart from MS when anti-AQP4 antibodies were found to be specific of this kind of disease.

Then it...

0 Replies

823 Views

Last post by frodo
Mon Jun 26, 2017 2:28 pm
Lipid metabolism linked to MS

Last post by frodo « Wed Jun 21, 2017 7:35 am
Replies: 1
by frodo » Tue Jun 13, 2017 1:50 pm

First post

The use of vibrational spectroscopy to study the pathogenesis multiple sclerosis and similar neurological conditions

They say more or less that...

Last post

Related to this, anti-acne medications has an effect

Acne drug slows MS development

1 Replies

874 Views

Last post by frodo
Wed Jun 21, 2017 7:35 am
New model of MS: Response against infected B-Cells

Last post by frodo « Wed Jun 21, 2017 6:37 am
Replies: 5
by frodo » Mon Mar 27, 2017 3:15 am

First post

A recent failure with Tysabri has shed some light into MS pathogenesis. It seems that is not EBV itself, but some B-cells infected by EBV, the cause...

Last post

More evidence about the EBV-infected b-cells theory:

Half of progressive MS patients treated with Epstein-Barr virus sensitised T-cells see symptom...

5 Replies

1202 Views

Last post by frodo
Wed Jun 21, 2017 6:37 am
Scientists discover possible trigger for MS

Last post by MSUK « Tue Jun 20, 2017 5:22 am

by MSUK » Tue Jun 20, 2017 5:22 am

Scientists in Israel have discovered an abnormality in neurons’ protective membrane that may allow the body’s immune system to attack itself by...

0 Replies

912 Views

Last post by MSUK
Tue Jun 20, 2017 5:22 am
Cross-talk between human glial cells and B cells

Last post by frodo « Sat Jun 17, 2017 6:19 am

by frodo » Sat Jun 17, 2017 6:19 am

Cross-talk between human glial cells and B cells help propagation of CNS-compartmentalized in progressive MS

Astrocytes supported MS B cell...

0 Replies

793 Views

Last post by frodo
Sat Jun 17, 2017 6:19 am
new biomarkers of disease progression linked to cholesterol

Last post by frodo « Sat Jun 17, 2017 6:06 am
Replies: 2
by frodo » Wed May 17, 2017 11:34 pm

First post

It seems that the Simvastatin connection is under research by the groups that investigate pathogenesis, and they have found that some...

Last post

More about biomarkers

Source:

... We developed in a training cohort ... two biomarker-based classifiers that differentiate:

1. MS from CNS...

2 Replies

1112 Views

Last post by frodo
Sat Jun 17, 2017 6:06 am
specific auto-antibodies in blood

Last post by frodo « Tue Jun 06, 2017 12:03 am
Replies: 2
by frodo » Mon May 22, 2017 9:58 am

First post

Researchers have found different auto-antibodies markers in blood in SPMS and RRMS. These different biomarkers could shed light into the...

Last post

More about blood tests. Morphogenetic proteins are required to grow stem cells into their final form, in this case, neurons and oligodendrocytes....

2 Replies

864 Views

Last post by frodo
Tue Jun 06, 2017 12:03 am
Rab32 connects ER stress to mitochondrial defects in MS

Last post by violin « Tue May 09, 2017 9:38 pm
Replies: 2
by NHE » Tue Apr 25, 2017 3:25 am

First post

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.
J Neuroinflammation. 2017 Jan 23;14(1):19.

BACKGROUND: Endoplasmic...

Last post

You are lots more scientific than I. All I know is my doctor told me a lot about hyperbaric oxygen chambers helping regenerate mitochondrial DNA in...

2 Replies

915 Views

Last post by violin
Tue May 09, 2017 9:38 pm
mitochondrial Rab32 involved

Last post by frodo « Tue May 09, 2017 8:36 am

by frodo » Tue May 09, 2017 8:36 am

Rab32 is a protein involved in mitochondrial stress. It has been found to be present in MS lesions and now it has been found to be specific of MS...

0 Replies

751 Views

Last post by frodo
Tue May 09, 2017 8:36 am
Die sogenannten Körner erschienen etwas körnig

Last post by frodo « Mon May 08, 2017 12:51 am

by frodo » Mon May 08, 2017 12:51 am

... which translated to English means The so called nuclei seemed more grainy . This was the conclusion of the German pathologyst Heinrich Müller...

0 Replies

731 Views

Last post by frodo
Mon May 08, 2017 12:51 am
Antibodies produced by B-cells attack spinal cord samples

Last post by frodo « Sun May 07, 2017 10:44 pm

by frodo » Sun May 07, 2017 10:44 pm

Some years ago it was found that the CSF of MS patients was able to produce a MS-like condition in mice. This other article maybe explains how it is...

0 Replies

763 Views

Last post by frodo
Sun May 07, 2017 10:44 pm
MS: A Functional Disorder

Last post by vesta « Sun May 07, 2017 9:01 am
Replies: 13
by vesta » Tue Apr 26, 2016 2:41 am

First post

MULTIPLE SCLEROSIS: A FUNCTIONAL DISORDER

If I had known that Multiple Sclerosis is essentially a problem of fluid circulation (blood,...

Last post

Hi Vesta

Congratulations for your brilliant and clear explanation about this complex desease. I agree with most of your points of view. You have...

13 Replies

2039 Views

Last post by vesta
Sun May 07, 2017 9:01 am
whatever Rituxan does, it does it outside the CNS

Last post by Scott1 « Sat Apr 29, 2017 10:03 pm
Replies: 1
by frodo » Sat Apr 29, 2017 3:36 am

First post

Whatever Rituxan does, it does it outside the CNS. PET imaging shows that Rituxan never enters the CNS at all. This leaves open the question about...

Last post

Hi,

That raises the intriguing idea of EBV infection. Latent EBV resides in the B cell so if you ablate to B cell you remove the EBV.

He mentions...

1 Replies

744 Views

Last post by Scott1
Sat Apr 29, 2017 10:03 pm
meningeal inflammation in early multiple sclerosis

Last post by Scott1 « Sun Apr 23, 2017 4:18 am
Replies: 2
by frodo » Sat Apr 22, 2017 11:14 am

First post

Whatever MS is, meningeal inflammation (and therefore gray matter damage) is present since the beginning.

Source:

Results:

A para-sulcal CL was...

Last post

Hi,
It may be too selective to just focus on meninges. They are just a part of a broader group of connective tissue called fascia. Varieties of...

2 Replies

806 Views

Last post by Scott1
Sun Apr 23, 2017 4:18 am
To boost or supress autoimmunity, that is the question

Last post by SeanReynolds « Wed Apr 19, 2017 6:30 pm
Replies: 4
by MSUK » Thu Sep 11, 2014 12:27 am

First post

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation....

Last post

If you look at the CPn (or even MAP) thesis, it is a very simple explanation indeed.

Dr Wheldon points to EBV, HHV-6 and potentially other viral...

4 Replies

1525 Views

Last post by SeanReynolds
Wed Apr 19, 2017 6:30 pm
Some forms of MS are inherited

Last post by SeanReynolds « Wed Apr 19, 2017 6:18 pm
Replies: 3
by frodo » Wed Apr 19, 2017 2:24 am

First post

Maybe EBV-infection is required to develop MS but a lot of people with EBV do not develop MS. There must be something more.

Some forms of MS could...

Last post

Once again, reading that Canadian/Australian research, the findings are completely consonant with acquiring a CPn type infection at some stage in the...

3 Replies

694 Views

Last post by SeanReynolds
Wed Apr 19, 2017 6:18 pm
The old posts of Leonard

Last post by SeanReynolds « Tue Apr 18, 2017 12:14 am
Replies: 1
by frodo » Sat Apr 15, 2017 2:42 am

First post

I have just stumbled upon some old post of Leonard. They are long but they contain a lot of information. I think that in a forum about etiology they...

Last post

Interesting reading about the EBV thesis.

I'm trying to see a connection with the CPn thesis, Dr Wheldon does point to a cumulative immune effect...

1 Replies

730 Views

Last post by SeanReynolds
Tue Apr 18, 2017 12:14 am
Is there a pulse wave encephalopathy component to MS?

Last post by SeanReynolds « Fri Apr 14, 2017 8:51 pm
Replies: 2
by NZer1 » Fri Mar 17, 2017 11:34 pm

First post

Is there a pulse wave encephalopathy component to multiple sclerosis?
Juurlink BH1.
Abstract
The dominant hypothesis in multiple sclerosis is that it...

Last post

The CPn/MAP thesis of a bacterial cause of MS resolves this puzzle completely.

2 Replies

888 Views

Last post by SeanReynolds
Fri Apr 14, 2017 8:51 pm
Research breathes new life into MS viral theory

Last post by SeanReynolds « Fri Apr 14, 2017 8:34 pm
Replies: 4
by MSUK » Thu Feb 12, 2015 5:38 am

First post

Research breathes new life into theory supporting possible viral etiology of multiple sclerosis

Several clusters of multiple sclerosis cases have...

Last post

Some have suggested Chlamydophila pneumoniae is the cause of MS, also pointing to the Faroe Islands case.

Easily spread by close contact.

4 Replies

1467 Views

Last post by SeanReynolds
Fri Apr 14, 2017 8:34 pm

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