subclinical activity in MS relatives

[frodo]

Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk

https://www.sciencedirect.com/science/a ... 8221001789

Highlights

• MRI evidence of MS pathology in healthy individuals reflects a subclinical period.
• First-degree relatives of MS patients are ideal to study MS subclinical neuropathology.
• MRI found WM focal inflammation in a substantial proportion of these healthy relatives.
• Diffuse tissue damage is also found by MRI in healthy relatives of MS patients
• MS prodromal phase can be characterized by studying healthy subjects at high risk.

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