Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration:
-Galectin-3 (Gal-3) is a pleiotropic protein that binds to β-galactoside residues present in glycoproteins.
-Gal-3 is mainly expressed and released in the damaged brain by reactive microglia.
-Gal-3 interacts with immune receptors like TREM2 and TLR4.
-Gal-3 appears upregulated in the transcriptomic profile of microglia in distinct neurodegenerative environments.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9300700/
PS: potent Galectin 3 inhibitor is Pectin widely available as supplement
Science Pinpoints Nutrients Crucial to Brain Health
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