Actual details on reduced Lymphocytes count?

Gilenya, or Fingolimod, is the first approved oral disease modifying drug for MS.
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CureOrBust
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Actual details on reduced Lymphocytes count?

Post by CureOrBust » Sun Dec 04, 2011 2:32 am

I tried doing a search to find the actual numeric effects on cell counts of circulating Lymphocytes before and after being on Gilenya. I didn't find it. The best I found was an approximation for mice in an experiment, who I would assume would of been on much more severe doses.

I would love to see the data from the Phase II and Phase III trials; which used different dosages? Is this data available anywhere?

Even better would be a graph plotting treatment response (eg EDSS) to Lymphocyte reductions, if there is any pattern to the response.

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Shayk
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Re: Actual details on reduced Lymphocytes count?

Post by Shayk » Sun Dec 04, 2011 6:52 pm

Hi Cure

I don't have a clue if the info you want is in these documents but this is a link to info
on the FDA website about Gilenya.

Take care

Sharon

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CureOrBust
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Re: Actual details on reduced Lymphocytes count?

Post by CureOrBust » Mon Dec 05, 2011 1:54 am

I did a quick skim read, and it appears to be a wealth of info. Thanks. :-BD

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lmacalus
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Re: Actual details on reduced Lymphocytes count?

Post by lmacalus » Mon Dec 19, 2011 11:27 am

Have you tried calling Novartis & asking them? Could it be contained in the PI?

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