cancer drug

[scorpion]

I am not sure how this differs from drugs like Campath but it sounded fairly interesting...


<shortened url>

[AlmostClever]

Quote:

"To make this discovery, scientists used two groups of mice—the first treated with bortezomib and the second with saline"

Do mice experience placebo? lol

[scorpion]

huh?

[patientx]

I don't know, but from my limited understanding it sounds pretty similar to Campath. It looks like the difference might be, whereas Campath, Rituxan, and other MABs, are actually antibodies that bind to T and B cells, this drug causes T cell death by inhibiting NF Kappa B activation (whatever that is). I guess the NF Kappa B is involved in activating inflammatory T-cells, so maybe that's how it leaves "good" T-cells unharmed.

[NHE]

I don't know, but from my limited understanding it sounds pretty similar to Campath. It looks like the difference might be, whereas Campath, Rituxan, and other MABs, are actually antibodies that bind to T and B cells, this drug causes T cell death by inhibiting NF Kappa B activation (whatever that is). I guess the NF Kappa B is involved in activating inflammatory T-cells, so maybe that's how it leaves "good" T-cells unharmed.

NF kappa B = Nuclear Factor kappa B. It's a transcription factor. When activated in cells, it goes into the nucleus and turns on the transcription of proinflammatory genes.

Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.

NHE

[patientx]

Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.

NHE

Interesting. Do you have some research that you could point to about these things inhibiting NFkB?

[cheerleader]

Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.

NHE

Interesting. Do you have some research that you could point to about these things inhibiting NFkB?

Jeff's been on EGCG for 3 years. As well as inhibiting NFkB, it is a BBB permeable chelator. Here's a paper on the NFkB affect:
http://jmm.sgmjournals.org/cgi/reprint/56/8/1042.pdf

Check out Charite (Berlin) studies on EGCG in pwMS. Impressive results.
cheer

[Frank]

Sorry to hijack the thread, but did the Charite already publish data on the EGCG trial?

Thanks!
--Frank

[NHE]

Here's an overview of some of the cell signalling pathways involved with NF-kB. More info related to the specific supplements can be found using Pubmed.

NHE