I have a question about the idea of increased blood flow having an effect on Angiotensin regulation - which might cause feeling of well-being and warm hands/feet (see mention of Dr Simka below). But was at first confused, as research was published in July saying the blocking of Angiotensin I receptors in the brain might be beneficial in MS. This seemed to be contradictory to benefits of increased Angiotensin through increased blood flow. But it seems the link is a different one.
Now read that there are 5 classes of Angiotensin but the one that will probably play a role in CCSVI is angiotensin III - might that then block the AT1 receptor?? Only found that increase of AngiotensionIII releases ACTH (increasing production and release of corticosteroids = could explain relief of some MS symptoms?) and the hormone/neurotransmitter Norepinephrine (increasing Serotonin and Dopamin = feeling of wellbeing).
Sorry if similar question was already posted, but could not find it here.
Angiotensin (AT1R) blockers are on the market, now wonder if these have to do with the other AT III findings. Could those be worth a try or too early to say? Any negative side effects?
Anti-hypertensive drug improves multiple sclerosis-related brain inflammation
>>The scientists working with Professor Platten showed in a mouse model that angiotensin II promotes inflammation in the brain and spinal cord. When the angiotensin receptors, i.e. the sites where angiotensin docks onto cells and can develop its effect, were blocked by the orally administered blood pressure drug Candesartan, the inflammation decreased and the paralysis resolved.<<
http://www.topnews.in/health/anti-hyper ... tion-28247
>>Multiple sclerosis -- antihypertensive drug ameliorate inflammation in the brain July 28, 2010
Researchers in Heidelberg and Stanford have discovered a new signalling pathway of brain cells that explains how widely used antihypertensive drugs could keep inflammation in multiple sclerosis (MS) in check. The peptide angiotensin not only raises blood pressure but also activates the immunological messenger substance TGF beta on a previously unknown communication pathway in the brain.<<
http://www.physorg.com/news199553831.html
>>PREMiSe Trial
OK It is now official. Buffalo neurosurgery is running a small trial on CCSVi. The trial is over six month and is called the (Prospective Randomized Endovascular therapy in Multiple Sclerosis).The trial will consist of 30 patients all on disease modifying drugs, the sensible thing to do in my opinion. The reason, it minimise the risk and those that have the "Sham Surgery" will not be negatively effected. A wise decision, as this trial is design a blinded trial. This will definitely exclude the possibility of a "Placebo Effect"." Placebo" is a possibilty but highly unlikely in my opinion.
The first face is the safety face where angioplasty will be done on 10 patients to check safety on it.
In this trial 10 will receive the actual treatment for CCSVI while 10 will receive "Sham treatments" consisting only of a venogram.
Here is where a lot will go that is unethical, but it is the best way to find the end point as such. Does CCSVI treatment helps Ms or is it a angiotensin or other effect? Just a bit on angiotensin effect. Certain angiotensins regulate body temp (feeling of warm hands and feet) while others increase serotonin and endorphins, creating the feeling of well being. Dr Simka stated not to long ago that this could be a possibility. With the increase of blood flow over the brain Angitensens does increase as well. This will give a better direction to the "cause and effect". But if the trial does show positive results it will be done on the 10 that had the sham as such<<.
http://www.themultiplesclerosis.com/breakingnews.htm
