Since ThisIs'MS', gadolinium-enhancing lesions

[Cece]

MegansMom, I find myself not commenting on your posts because they leave nothing more to be said. You put things very clearly, thank you.

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We can tell the difference when we can see that the cellular distress is causing the influx of immune cells. I hate to say it, but find a way to give an experimental animal a case of slow flow combined with reflux, and you will see if this is enough to break down myelin, cause lesions, etc. It may be necessary to choose an animal with a long enough life-span.

Actually, wasn't this already done with dogs?

I believe that Putnam tried something like this around 1930...
but was injecting various things into their veins, not crimping the veins and causing reflux.....

And if you're going to set this type of trial up, don't let PETA know.....

One concern with animal trials is how different the cerebral vascular drainage is in animals that do not walk upright, compared to humans.

There were CCSVI mice trials at Stanford, we've not yet heard what's come of those.

[1eye]

Isn't the body's normal response to injury at first to form a clot? Not ascribing any innate intelligence to individual cells, but maybe there is some kind of defense against clots forming in the brain? Maybe the lesion is a normal response to low-level blood vessel damage in the brain.

Normally, isn't a short-term physiological response to damage to send out major troops to defend breaches? Then later on, inflammation if things are not antiseptic? Like if you use alcohol on a cut, infection clears, but if you don't it stays inflamed and tries to wipe out pathogens. But in this case there may be no pathogen other than what is in normal blood, maybe in higher concentrations at the injury site. So perhaps this is a case of "If this were a real emergency, you would have been instructed..." If there was a real pathogen you'd be dead by now.

Maybe there is some chronic damage happening, and these scars are a response to it.