MN doctor -CCSVI - Dr. Michael Cumming

DrCumming · Post by **DrCumming** » Mon Jan 03, 2011 12:29 pm

Cece wrote:I am lousy at going quiet, it is like holding my breath.

If others here are unaware, Dr. Cumming is from Canada originally, I have wondered what his perspective is on the Canadian situation.

Now that's opening Pandora's box.

Two of the big issues...

1. Research... this I think is dismal. Given the high incidence of MS and the lack of any meaningful studies going on is embarrassing. Politics at work.

2. Treatment. In Canada (and in all of the world, even the US), health care is rationed. It simply has to be. There are not enough dollars to cover all available services. So, given the lack of conclusive evidence around CCSVI and its treatment, you definitely could argue that the system should not pay. However, the system does not have any criteria that defines when a procedure should or should not be covered. So, all diseases are not treated equal. With self paying patients, its seem silly to have these dollars flowing out of the country. Its also not good care - especially for this procedure which has durability issues and requires good longitudinal follow up.

DrCumming · Post by **DrCumming** » Mon Jan 03, 2011 12:36 pm

Brainteaser wrote:Dr Cumming - apart from using smaller balloons, do you have any protocol for minimizing intimal injury; do blood thinners help? I'm not sure Cece is correct regarding the 3 month restenosis timeframe. Some patients are being retreated after only a couple of weeks.

Intimal injury is a part of the ballooning process. It always happens. Even the passage of a guide wire has been shown to cause injury. So, options include smaller balloons, dilating using the minimum amount of pressure, and not ballooning nearby normal vein.

Early restenosis maybe from collapse of the vein (also called elastic recoil) or aggressive intimal hyperplasia (and other causes). The time frame is variable from patient to patient.

Blood thinners (warfarin, heparin) or antiplatelet agents (plavix, aspirin) are primarily used to prevent acute thrombosis. They do not inhibit intimal hyperplasia. Tools for this include drug eluting stents and balloons and other strategies.

DrCumming · Post by **DrCumming** » Mon Jan 03, 2011 12:39 pm

Brainteaser wrote:Cece, I'd like to hear what Dr Cumming has to say on this very serious issue. As you quote '....repeated dilatation causes repeated intimal injury and perpetuates the intimal healing response. ' If people are being retreated frequently, there is greater potential for intimal damage. Additionally, my reading of 'Re-stenosis occurring 3 to 12 months after angioplasty is typically due to intimal hyperplasia.' does not necessarily mean that there can't be intimal damage in less than 3 months.

We know, from our dialysis patient population, that we can safely redilate veins many many times. I have a group of patients that routinely come in every 3 - 6 months for repeat dilation.

We always cause intimal injury by ballooning. To gain luminal diameter, it has too happen.

Cece · Post by **Cece** » Mon Jan 03, 2011 2:59 pm

mjc701 wrote:Blood thinners (warfarin, heparin) or antiplatelet agents (plavix, aspirin) are primarily used to prevent acute thrombosis. They do not inhibit intimal hyperplasia.

Are you sure the antiplatelet drugs might not play some palliatory role? As I understand it, the platelets attach to the sites of intimal injury and release platelet-derived growth factors that have an impact on smooth muscle cell proliferation which is a component of intimal hyperplasia.

diagram showing this:
http://content.onlinejacc.org/cgi/conte ... 3/555/FIG1

DrCumming · Post by **DrCumming** » Mon Jan 03, 2011 6:22 pm

Cece wrote:
mjc701 wrote:Blood thinners (warfarin, heparin) or antiplatelet agents (plavix, aspirin) are primarily used to prevent acute thrombosis. They do not inhibit intimal hyperplasia.
Are you sure the antiplatelet drugs might not play some palliatory role? As I understand it, the platelets attach to the sites of intimal injury and release platelet-derived growth factors that have an impact on smooth muscle cell proliferation which is a component of intimal hyperplasia.

diagram showing this:
http://content.onlinejacc.org/cgi/conte ... 3/555/FIG1

Yes, that is correct. Always caught between making things too complex or too simple when explaining to non MDs. Of course, your interest and background are an exception

thornyrose76 · Post by **thornyrose76** » Thu Jan 06, 2011 11:56 am

Dr. Cumming- I was curious to know when you will officially become apart of the Hubbard Registry? And also, will info be posted at your website the Vein Care Clinic in regards to you treating CCSVI?

DrCumming · Post by **DrCumming** » Thu Jan 06, 2011 12:04 pm

thornyrose76 wrote:Dr. Cumming- I was curious to know when you will officially become apart of the Hubbard Registry? And also, will info be posted at your website the Vein Care Clinic in regards to you treating CCSVI?

Hi, we are navigating the IRB process. This is going to take time. I also need to convince senior leadership that we should be participating. Otherwise, we are basically ready with the Haake MR protocols etc. in place. My best guess is late springtime.

Cece · Post by **Cece** » Sat Jan 08, 2011 9:01 am

Just saw Dr. Cumming name-dropped (and picture-dropped) on Facebook by a patient treated three months ago who is doing well.

Kathryn333 · Post by **Kathryn333** » Mon Jan 17, 2011 1:01 pm

How long is the waiting time for Dr. Cumming? The patient is a Canadian, and he would be paying cash.

Thanks.

thornyrose76 · Post by **thornyrose76** » Mon Jan 17, 2011 2:12 pm

Dr. Cumming:

What blood thinner do you believe is best post procedure?

DrCumming · Post by **DrCumming** » Tue Jan 18, 2011 6:56 am

Kathryn333 wrote:How long is the waiting time for Dr. Cumming? The patient is a Canadian, and he would be paying cash.

Thanks.

Hi Kathyrn,

We typically are booking 2-4 weeks out. Our price is $10,000 including initial evaluation, ultrasound, venogram and venoplasty.

Typically, I do like to speak with individuals prior to coming to make sure we are on the same page and that I can answer questions prior to making the trip.

DrCumming · Post by **DrCumming** » Tue Jan 18, 2011 7:01 am

thornyrose76 wrote:Dr. Cumming:

What blood thinner do you believe is best post procedure?

I wish I knew....

I have talked to a few people at Iset and everyone is doing something different.

In Glasgow, I talked with some of the higher volume operators. They reported a few acute vein thrombosis (clot) when using aggressive (ie cutting balloon/wire) techniques. So, in these cases I feel strongly that lovenox be used.

Otherwise, apirin/plavix is probably a good option. Some people are doing aspirin only. Others doing lovenox and then transitioning to warfarin. Some nothing.

So no great answer. I recommend doing lovenox unless cost or doing the injections is not feasible. In that case aspirin/plavix is probably reasonable.

DrCumming · Post by **DrCumming** » Tue Jan 18, 2011 7:02 am

Cece wrote:Just saw Dr. Cumming name-dropped (and picture-dropped) on Facebook by a patient treated three months ago who is doing well.

i hope it was a good picture!

Kathryn333 · Post by **Kathryn333** » Wed Jan 19, 2011 11:51 am

DrCumming wrote:
Kathryn333 wrote:How long is the waiting time for Dr. Cumming? The patient is a Canadian, and he would be paying cash.

Thanks.
Hi Kathyrn,

We typically are booking 2-4 weeks out. Our price is $10,000 including initial evaluation, ultrasound, venogram and venoplasty.

Typically, I do like to speak with individuals prior to coming to make sure we are on the same page and that I can answer questions prior to making the trip.

Thank you, Dr. Cumming. I have passed on the info to the patient.

Cece · Post by **Cece** » Fri Jan 21, 2011 9:01 am

DrCumming wrote:We typically are booking 2-4 weeks out. Our price is $10,000 including initial evaluation, ultrasound, venogram and venoplasty.

Terminology can be a bear: by venogram, do you mean the MRV or the catheter venogram?

Can you tell us at all what you have experienced with the MRVs as part of the diagnostic process? Do they hold up to what you see in the catheter venogram? Have you had anyone back for a repeat MRV after a successful venoplasty? I've also been wondering for awhile: if there is a figure for "backward flow" in the flow chart information for the jugulars, does this mean backward toward the brain or backward toward the heart?

Typically, I do like to speak with individuals prior to coming to make sure we are on the same page and that I can answer questions prior to making the trip.

I think that shows good care.

I wish I knew too about the anticoagulants. Thank you for sharing your thoughts and what you've been hearing.