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I posted this a while back about a study that shows Viagra increases the permeability of the Blood Brain Barrier, which I don't think would be too advantageous to PwMS.
Thank you for re-posting that. I guess that would probably be a bad thing for us, but then again if the BBB is already being breached, then maybe wouldn't matter much.
There are apparently others. Levitra is one good one.
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Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
.. and what about L-argine? It is quite commonly used by athletes and men with erection problems use it. It helps with Nitric oxide production in veins and there are many studies about it.. mostly with lab-rats, like this:
"L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats"
--> These studies support the theory that L-arginine administration improves post-traumatic cerebral blood flow by increasing NO production
PS. and some info in livestron.com "L-Arginine Effects on the Brain"
I have definitely noticed a difference in balance and mobility 'the day after' V. I am going to request the daily does of cialis from my doc this week and do my own study.
jay123 wrote:I have definitely noticed a difference in balance and mobility 'the day after' V. I am going to request the daily does of cialis from my doc this week and do my own study.
Lucky you! Hope it continues to work for you. Anything that can help us!
VIAGRA MAY BE NEUROPROTECTIVE & REDUCE MS SYMPTOMS
Seemed to be good for mice with EAE who were given it for 8 days. Details in press release from UAB: http://www.uab.es/PDF/PDF_1306480140723_en.pdf
No info on dose. If action is neuroprotective may work in females. Applies to similar (PDE5) drugs.
MarkW
Mark Walker - Oxfordshire, England. Retired Industrial Pharmacist. 24 years of study about MS.
CCSVI Comments:
http://www.telegraph.co.uk/news/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
dc10 wrote:...also what risks am i taking by using a daily dose of cialis for 2 weeks?
thanks
Two weeks of non-stop headache seems like a heavy price to pay for whatever benefit you may achieve. But, good luck.
I suppose not everyone gets a headache from cialis, but many do. I don't know if this side effect is dose-dependent, but I'd read up on potential side-effects of cialis if I were you.
--Tracy
CCSVI Procedure 9/16/2009 at Stanford
Stent in left and right IJVs
SPMS
Copaxone
Former Ampyra User
Regular Botox Bladder Injections
300mg d-Biotin / day
Ernst wrote:.. and what about L-argine? It is quite commonly used by athletes and men with erection problems use it. It helps with Nitric oxide production in veins and there are many studies about it.. mostly with lab-rats, like this:
"L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats"
--> These studies support the theory that L-arginine administration improves post-traumatic cerebral blood flow by increasing NO production
PS. and some info in livestron.com "L-Arginine Effects on the Brain"
I've been looking into L-Arginine as a potential supplement. What I find worisome is that Viagra and L-Arginine increase nitric oxide - though through different mechanisms.
NO has a role in several features of the disease, including disruption of the blood—brain barrier, oligodendrocyte injury and demyelination, axonal degeneration, and that it contributes to the loss of function by impairment of axonal conduction
However, despite these considerations, the net effect of NO production in MS is not necessarily deleterious because it also has several beneficial immunomodulatory effects. These dual effects may help to explain why iNOS inhibition has not provided reliable and encouraging results in animal models of MS, but alternative approaches based on the inhibition of superoxide production, partial sodium-channel blockade, or the replacement of lost immunomodulatory function, may prove beneficial.