Yellow fever vaccine risky for MS patients

MSUK · Post by **MSUK** » Wed Jun 15, 2011 4:19 am

Patients with multiple sclerosis who plan to travel to areas where yellow fever is endemic need to think carefully about whether to be vaccinated against the disease, researchers warned in a report on their small study.

During a five-week at-risk period after vaccination, the annual rate of MS exacerbation was 8.57, compared with a rate of 0.67 after the end of the risk period, according to Mauricio F. Farez, MD, MPH, and Jorge Correale, MD, of Fundación para la Lucha contra las Enfermedades Neurológias de la Infancia in Buenos Aires, Argentina.

This gave an exacerbation rate ratio for the risk period of 12.778 (95% CI 4.28 to 38.13, P<0.001), the researchers reported online in the Archives of Neurology.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1329

carolsue · Post by **carolsue** » Wed Jun 15, 2011 10:40 am

thanks for this! Very timely for me, as I have an appt with the travel nurse next week. I will be going to Brazil, where yellow fever exists, but to a part of a state that does NOT have yellow fever. After reading this, I will probably opt out of the vaccine.

Talisker · Post by **Talisker** » Thu Jun 23, 2011 12:03 pm

http://www.ajcn.org/content/34/2/229.full.pdf

This study demonstrates that a subclinical
infection significantly alters various aspects
of intermediary metabolism. The variable
most affected was insulin, since the level was
increased by infection and further increased
by dietary protein ingestion after infection

and thats immunization

carolsue · Post by **carolsue** » Wed Jul 20, 2011 7:55 am

So are there any folks out there with MS who have had the yellow fever vaccine? Did you have a relapse?

Weighing my options for African travel now...