Low testosterone is associated with disability in MS men

[Kronk]

I agree that saturated fat is required in a healthy adults diet, but I have MS, and in my case i believe saturated fats are not beneficial. The original Swank study is what i put the most faith in due to its direct focus on disability progression and the results demonstrated. It was critized for a lack of study controls but that does not change the fact that the majority of participants remained ambulant into there 70s. You can fake statistics and tweak percentages but you cannot fake pwMS walking around and remaining active late in life.

a couple would be good, maybe there's a review article or something?

Take your pick, you can just dump the title into google to get the content. I had the links for the last dozen or so in my bookmarks. I found the saturated fat damaging the endothelial particularly interesting as many consider MS to be a BBB issue more than auto-immune.

original Swank study
https://jama.jamanetwork.com/article.as ... ultClick=1

Swank RL. Multiple sclerosis: a correlation of its incidence with dietary fat. Am J Med Sci 1950; 220:421-430.

Swank RL, Dugan BB. The multiple sclerosis diet book. A low fat diet for the treatment of MS. New York: Doubleday, 1987

Swank RL, Dugan BB. Effect of low saturated fat diet in early and late cases of multiple sclerosis. Lancet 1990; 336:37-39

Swank RL. Multiple sclerosis: fat-oil relationship. Nutrition 1991; 7:368-376

Ben-Shlomo Y, Davey Smith G, Marmot MG. Dietary fat in the epidemiology of multiple sclerosis: has the situation been adequately assessed? Neuroepidemiology 1992; 11:214-225.

Swank RL, Goodwin J. Review of MS patient survival on a Swank low saturated fat diet. Nutrition 2003; 19:161-162

Das UN. Is there a role for saturated and long-chain fatty acids in multiple sclerosis? Nutrition 2003; 19:163-166

Nordvik I, Myhr KM, Nyland H, et al. Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients. Acta Neurol Scand 2000; 102:143-149.

Weinstock-Guttman B, Baier M, Park Y, et al. Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients. Prostaglandins Leukot Essent Fatty Acids 2005

Schwarz S, Leweling H. Multiple sclerosis and nutrition. Mult Scler 2005; 11:24-32

Holman RT, Johnson SB, Kokmen E. Deficiencies of polyunsaturated fatty acids and replacement by nonessential fatty acids in plasma lipids in multiple sclerosis. Proc Natl Acad Sci USA 1989; 86:4720-4724

Nightingale S, Woo E, Smith AD, et al. Red blood cell and adipose tissue fatty acids in mild inactive multiple sclerosis. Acta Neurol Scand 1990; 82:43-50

Cunnane SC, Ho SY, Dore-Duffy P, et al. Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. Am J Clin Nutr 1989; 50:801-806

Lauritzen I, Blondeau N, Heurteaux C, et al. Polyunsaturated fatty acids are potent neuroprotectors. Eur Mol Biol Org J 2000; 19:1784-1793

Blondeau N, Widmann C, Lazdunski M, et al. Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 2002; 109:231-241

Mayer M. Essential fatty acids and related molecular and cellular mechanisms in multiple sclerosis: a new look at old concepts. Folia Biologica (Praha) 1999; 45:133-141

McCarty MF. Upregulation of lymphocyte apoptosis as a strategy for preventing and treating autoimmune disorders: a role for whole-food vegan diets, fish oil and dopamine agonists. Med Hypotheses 2001; 57:258-275.

Sat fat effect on the endothelium (BBB)
http://www.ncbi.nlm.nih.gov/pubmed/3606733

Endothelial description
http://www.lab.anhb.uwa.edu.au/mb140/mo ... dothel.htm

Sat fat damaging endothelial cells particularly palmitic and stearic
http://www.ncbi.nlm.nih.gov/pubmed/1604444

Low fat diets reduce thrombin
http://www.researchgate.net/publication ... w_fat_diet

Thrombin and subendothelium
http://www.ncbi.nlm.nih.gov/pubmed/11307830

Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function.
http://www.ncbi.nlm.nih.gov/pubmed/16904539

Consumption of an SAFA-rich meal is harmful for the endothelium, while a MUFA-rich meal does not impair endothelial function
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584179/

saturated NEFAs (palmitate and stearate) are proapoptotic, and unsaturated NEFAs (palmitoleate, oleate, and linoleate) are antilipoapoptotic
http://diabetes.diabetesjournals.org/co ... /3121.full

BBB issue in MS
http://www.ncbi.nlm.nih.gov/pubmed/14664465

BBB functional roles
http://www.ncbi.nlm.nih.gov/pubmed/17453713

EBV and Fatty Acids
http://www.ncbi.nlm.nih.gov/pubmed/15047835

[jimmylegs]

thx

saturated fat damaging the endothelial particularly interesting as many consider MS to be a BBB issue more than auto-immune

perfect, i can provide complementary research for insight on that aspect. (later - physio shortly)