New article about Iron chelators sheds light upon MS

[frodo]

The idea of this article is that Iron can initiate a neurodegeneration which in turn activates microglia.

The importance of this is because NAWM consist mainly in activated microglia, and pre-active lesions, the first stage of a lesion development, are basically clusters of activated microglia.

Therefore according to this model, the MS chain of events would be:

Iron Accumulation -> Activated Microglia -> NAWM and pre-active lesions -> BBB breakdown -> T-cells and B-cells autoimmunity -> Myelin destruction

Quite different from the standard model of autoimmunity. Below I copy the new article. The rest of the information is easy to find using google (see for example http://www.direct-ms.org/pdf/Immunology ... eDegen.pdf).

The paper:

Neurodegenerative Diseases and Therapeutic Strategies using Iron chelators

http://www.sciencedirect.com/science/ar ... 2X15000061

This review will summarise the current state of our knowledge concerning the involvement of iron in various neurological diseases and the potential of therapy with iron chelators to retard the progression of the disease.

We first discuss briefly the role of metal ions in brain function before outlining the way by which transition metal ions, such as iron and copper, can initiate neurodegeneration through the generation of reactive oxygen and nitrogen species. This results in protein misfolding, amyloid production and formation of insoluble protein aggregates which are contained within inclusion bodies. This will activate microglia leading to neuroinflammation.

Neuroinflammation plays an important role in the progression of the neurodegenerative diseases, with activated microglia releasing pro-inflammatory cytokines leading to cellular cell loss. The evidence for metal involvement in Parkinson's and Alzheimer's Disease as well as Friedreich's Ataxia and Multiple Sclerosis will be presented. Preliminary results from trials of iron chelation therapy in these neurodegenerative diseases will be reviewed.

[1eye]

Absolutely. This is just what a lot of us have been saying about the chain of events. What do they say about chelation?

Now they have also to pay attention to stats about all the things that can cause iron poisoning of the brain. BBB breakdown is in itself a vicious cycle -> death!

[1eye]

also see my reply in General Discussion to the "Pathological Mechanisms" paper...

[frodo]

also see my reply in General Discussion to the "Pathological Mechanisms" paper...

Very interesting, thanks.

I put here the link for other people.

http://www.thisisms.com/forum/general-d ... 25921.html