Cerebral circulation time in MS is double that of normals

[1eye]

As I said, this is about safety and efficacy of HBO-induced healing after CCSVI angioplasty. There has never been such a study. The carpng of UK scientists over Pounds and immune sytems and fat emboli won't get us any closer to that. These studies are in complete absence of angioplasty. Arguments about its effects on MS, while nice to have, are irrelevant to damage caused by ballooning, or clot formation or scarring thereafter. While neuros and non-neuros continue to argue about whether the UK National Health got it right or not, pwMS elsewhere who have had CCSVI procedures and have had or worried about vein damage are left in the lurch.

Damage is best healed before clotting or scarring occurs.

So as usual, the pwMS is left to pay. This is why it's called bleeding edge.

The Canadian health system would just say "Well, we told you not to, so we won't treat any problems that result.". "You're on your own." What else is new?

[Sharon]

You all might be interested in an earlier study (2012) on CCT.
http://pubs.rsna.org/doi/abs/10.1148/radiol.11111239
They found that:

CCT was not significantly different between patients with MS who had CCSVI and patients with MS who did not (P = .182).

Dr Marco Salvatore was investigator in this study -- he is this year's ISNVD Conference President. I posted on Facebook this morning https://www.facebook.com/pages/CCSVI-Al ... 199777708/

Sharon

[cheerleader]

thanks for that earlier study and for the FB post, Sharon!
Great info.
I'd forgotten this one from Naples. The full paper is available here:
http://pubs.rsna.org/doi/full/10.1148/radiol.11111239

differences include the fact that this earlier study used ultrasound, not angiography, but the results are very similar. Cerebral circulation time was prolonged in all pwMS, when compared to normals.

The IJVs are the main drainage pathway of cerebral blood in the supine position in physiologic circumstances, and in patients with MS, the median time that contrast medium takes to transit from the cerebral arteries to the veins was about 1 second longer than that in control subjects. The difference observed between patients with MS and control subjects (1 second) corresponds to 20% of the median value in control subjects and more than one complete cardiac cycle. Many patients with MS showed a CCT that was two or three times longer than that in control subjects. A delay of this magnitude might derive from macro- or microcirculatory abnormalities, at least in a subgroup of patients. Our results are consistent with those of many studies that showed a decrease in cerebral perfusion in normal-appearing white matter and vascular changes associated with MS (2–5).

they also looked specifically at veins in this study:

Jugular reflux of contrast agent was observed with a higher frequency in the veins of patients with MS (45 [22%] of 204 observations vs seven (8%) of 83 observations,

and even after removing those veins with reflux, the CTT was still longer in MS.

Even after jugular veins with retrograde flow were excluded from the statistical analysis, CCT remained significantly longer in the MS group (CCT was 5.3 seconds [range, 1.7–15.1 seconds] in 159 [78%] of 204 veins without retrograde flow vs 4.9 seconds [range, 2.2–7.6 seconds] in 45 [22%] of 204 veins with retrograde flow, P = .014).

cheer

[1eye]

CCT can be high because of veins or arteries. If it's neither (and CCSVI did not seem to affect it) then perhaps it is high blood pressure. Doubling arterial blood pressure in arteries will be extremely dangerous but since venous pressures are low to start with, maybe a doubling will be less noticeable.

Or capillaries could be having trouble, or missing.