Single drop of blood in brain can activate response.....

[MSUK]

Single drop of blood in brain can activate autoimmune response

A new study from the Gladstone Institutes shows a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS). This is the first demonstration that introduction of blood in the healthy brain is sufficient to cause peripheral immune cells to enter the brain, which then go on to cause brain damage... Red more - http://www.ms-uk.org/MSnews

[cheerleader]

It's true.

All it takes to create MS is one drop of blood in the brain. You don't need a rogue virus, or auto-immune t-cells. Don't need to inject mice with foreign antigens to create EAE. Just one bit of blood breaking thru the blood brain barrier.

And we know that people with MS have micro bleeds. Dr. Yulin Ge (NYU) has documented this on 7T MRI and presented his research at the 2014 International Society for Neurovascular Disease conference.

MS is a vascular disease which initiates an immune reaction.
For more info and links to research:
http://ccsviinms.blogspot.com/2015/10/a ... blood.html


cheer

[CureOrBust]

A break in the blood-brain barrier (BBB) allows blood proteins to leak into the brain and is a key characteristic of MS. However, it was unclear whether the BBB disruption caused the autoimmune response or resulted from it.

In the current study, published in Nature Communications, the scientists created a new animal model of disease to determine if BBB leakage can cause autoimmunity. They discovered that injecting just one drop of blood into the brain set off the brain's immune response, kick-starting a chain reaction that resulted in inflammation and myelin damage. Myelin is the protective sheath that insulates nerve fibres in the brain, and it is the primary site of injury in MS. Scientists were able to pinpoint a specific protein in the blood, the blood-clotting factor fibrinogen, as the trigger for the disease-causing process.

If I am reading this correctly, and using the correct assumptions, they took a healthy animal (guessing a mouse) and simply inject a drop of blood into the animals brain? and this triggered demylination? is it just me or is this something that would of been tried before because of its simplicity? Although they have also identified what it is in the blood. The actual process appears fairly straightforward and would of been tried previously, no?

PS: do I see a possible share price hit to Tovaxin (or whatever they call it these days)...

[cheerleader]

If I am reading this correctly, and using the correct assumptions, they took a healthy animal (guessing a mouse) and simply inject a drop of blood into the animals brain? and this triggered demylination? is it just me or is this something that would of been tried before because of its simplicity? Although they have also identified what it is in the blood. The actual process appears fairly straightforward and would of been tried previously, no?

PS: do I see a possible share price hit to Tovaxin (or whatever they call it these days)...

You are reading this correctly, Cure.
Healthy mouse, one drop of healthy blood directly on brain tissue. Gladstone Institutes in Silicon Valley is honing in on fibrinogen, the clotting protein. However, we know many plasmic particles, including iron, are damaging to the brain.

It's in my blog post, Cure. http://ccsviinms.blogspot.com/2015/10/a ... blood.html Stroke researchers have known about the immune reaction in humans and animals for many years. I first wrote about this in 2010. http://ccsviinms.blogspot.com/2010/12/t ... troke.html But MS researchers have willfully ignored the evidence. Now, with this new animal model---which is a vastly more elegant model than EAE---they simple cannot ignore it any longer. And MS patients, advocates and societies, need to demand further research into this model. None of the current immune ablating drugs (deemed too toxic to give to stroke patients) will suffer any losses until this information is shared by pwMS.

cheer

[cheerleader]

People with MS show tiny micro bleeds into brain tissue, only seen on 7T MRI. Dr. Yulin Ge (NYU) has been behind this investigation. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579786/

These tiny breaks in the blood brain barrier precede demyelination.
Now that we know how a single drop of blood can instigate immune activity and myelin destruction, the unique pattern of MS lesions begin to make sense.

Tiny deposits of plasmic particles along venules, only visible on 7T MRI. Creating the tell-tale MS lesions.
http://ccsviinms.blogspot.com/2015/10/a ... blood.html

This is MS,
cheer

[CureOrBust]

I came across the following, and thought the rtesearch may be related.
http://www.msra.org.au/platelets-centra ... -detection

Summary
Recent evidence strongly suggests that blood particles known as ‘platelets’ may play a significant role in neuroinflammation. Platelets are very small cells that normally circulate in the blood and play a critical role in blood clotting. Recent research suggests that they may also have a pivotal role in inflammation, including neuroinflammation. There is clear evidence that platelets can be found in MS lesions and studies using the animal model for MS, known as experimental autoimmune encephalomyelitis (EAE), have shown that when the number of platelets in the circulation is lowered, disease severity is significantly reduced.

Investigations that Dr Peter and his team conducted in their laboratory of brain and spinal cord in EAE are in agreement with these findings and also demonstrated that platelet involvement begins early in disease development. In this project the team will confirm and extend these results by establishing the timing and the functional nature of the interaction between platelets and inflammatory cells in the EAE model. They will also develop imaging methods to assist in the early mapping of MS lesions using novel techniques for tracing platelets. This innovative involves a unique collaboration of three scientists, combining experience in the mouse EAE model, expertise in platelet biology and in imaging.

FYI: Apart from links to the researchers and institute, the above is the majority of info on the page.

[1eye]

platelets can be found in MS lesions and studies using the animal model for MS, known as experimental autoimmune encephalomyelitis (EAE), have shown that when the number of platelets in the circulation is lowered, disease severity is significantly reduced.

In EAE you can reduce the severity by reducing the availability of murine platelets? I am continually amazed at the lengths supposedly scientific researchers will go in an attempt to somehow rehabilitate or extract something approaching relevance from the completely bankrupt and useless "EAE" "model".

[centenarian100]

People with MS show tiny micro bleeds into brain tissue, only seen on 7T MRI. Dr. Yulin Ge (NYU) has been behind this investigation. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579786/

These tiny breaks in the blood brain barrier precede demyelination.. r

They seem to think that the changes actually precede breakdown of the blood brain barrier

"We propose that these small lesions represent an early stage of MS plaque development, marked by beginnings of transendothelial migration of vascular inflammatory cells of lymphocytes and macrophages without apparent BBB breakdown."

[cheerleader]

Centenarian--sorry, I should have clarified---that paper was the beginning of Ge's investigation in 2008.
A Seven-Tesla Magnetic Resonance Imaging--New Vision of Microvascular Abnormalities in Multiple Sclerosis
http://archneur.jamanetwork.com/article ... eid=795700

Dr. Ge stated at ISNVD conference in 2014 that he actually now sees micro bleeds, or blood particles in brain tissue, using a combination of SWI and 7T MRI. And this is what Haacke's team has been seeing, as well, as discussed at the 2015 Canadian Neurovascular Conference. Publications will follow.

sorry for confusion--
cheer

[NHE]

Centenarian--sorry, I should have clarified---that paper was the beginning of Ge's investigation in 2008.
A Seven-Tesla Magnetic Resonance Imaging--New Vision of Microvascular Abnormalities in Multiple Sclerosis
http://archneur.jamanetwork.com/article ... eid=795700

For some reason that link isn't working for me. This one does though...

http://www.ncbi.nlm.nih.gov/pmc/article ... s76056.pdf

[1eye]

80 MS lesions,

all associated with centrally-coursing veins.

The

angiocentric pattern of MS lesions,

together with the knowledge that a single drop of blood can cause damage to the brain, should be enough to categorically state that MS is a disease caused by and associated with veins in the CNS.