Supplements while awaiting bloodwork?

[kw202]

I decided to start with everything except b12 as that's the only test I have pending.

The bottle says "chelated magnesium" ... I think this may not be the ideal form?

[NHE]

I decided to start with everything except b12 as that's the only test I have pending.

The bottle says "chelated magnesium" ... I think this may not be the ideal form?

Chelated is usually good as it implies that it is chelated with an amino acid. Does the label indicate what the chelator is, e.g., magnesium glycinate ?

[NHE]

Just wanted to report that I started the 50000 IU weekly D2 dose yesterday, and considering that works out to a daily total ofa bout 7100 IU, D2's relative effectiveness (and my weight), I decided to also supplement on my own with 3000 IU D3 daily.

Re: D2 vs. D3 efficacy...

Vitamin D2 is much less effective than vitamin D3 in humans.
J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91.

Vitamins D(2) and D(3) are generally considered to be equivalent in humans. Nevertheless, physicians commonly report equivocal responses to seemingly large doses of the only high-dose calciferol (vitamin D(2)) available in the U.S. market. The relative potencies of vitamins D(2) and D(3) were evaluated by administering single doses of 50,000 IU of the respective calciferols to 20 healthy male volunteers, following the time course of serum vitamin D and 25-hydroxyvitamin D (25OHD) over a period of 28 d and measuring the area under the curve of the rise in 25OHD above baseline. The two calciferols produced similar rises in serum concentration of the administered vitamin, indicating equivalent absorption. Both produced similar initial rises in serum 25OHD over the first 3 d, but 25OHD continued to rise in the D(3)-treated subjects, peaking at 14 d, whereas serum 25OHD fell rapidly in the D(2)-treated subjects and was not different from baseline at 14 d. Area under the curve (AUC) to d 28 was 60.2 ng.d/ml (150.5 nmol.d/liter) for vitamin D(2) and 204.7 (511.8) for vitamin D(3) (P < 0.002). Calculated AUC(infinity) indicated an even greater differential, with the relative potencies for D(3):D(2) being 9.5:1. Vitamin D(2) potency is less than one third that of vitamin D(3). Physicians resorting to use of vitamin D(2) should be aware of its markedly lower potency and shorter duration of action relative to vitamin D(3).

[kw202]

Wow that chart really says it all NHE. I'm prescribed an 8-week course of d2 50k iu weekly but my insurance will only pay for a months worth at a time ( ) however I do have a total of 150 iu on hand after taking the first dose on Monday and I'm thinking about just taking it all today plus a follow up daily maintenance dose of d3 of some amount. (Then in January when I get my other four d2 pills I'll take all of those at once too).

My levels are so low and I'm a big lady (5'11 310#) and I'm not confident this level of megadose will get me to where I want to be as quickly as I need it to.

Any problems with this approach? Should I take even more? (I've heard of people at my levels taking up go 500000 iu)

Suggestions on a daily dose level for post-megadose?

Suggestions for accompaniments (like magnesium levels)

So many thanks!

NHE, I'm not sure. I don't recall seeing that word on the front of the bottle but I'll investigate more. EDIT: The ingredient list says magnesium stearate. Would that be it? This is a bottle that's vanity branded a local whole foods market's brand - I just called them and they said it's glycinate, but I don't entirely trust that.

[NHE]

Wow that chart really says it all NHE. I'm prescribed an 8-week course of d2 50k iu weekly but my insurance will only pay for a months worth at a time ( ) however I do have a total of 150 iu on hand after taking the first dose on Monday and I'm thinking about just taking it all today plus a follow up daily maintenance dose of d3 of some amount. (Then in January when I get my other four d2 pills I'll take all of those at once too).

My levels are so low and I'm a big lady (5'11 310#) and I'm not confident this level of megadose will get me to where I want to be as quickly as I need it to.

Any problems with this approach? Should I take even more? (I've heard of people at my levels taking up go 500000 iu)

Here's my idea, show the study's abstract and data plots to your doctor and tell them you want vitamin D3. From the study's data, it looks like megadoses of D2 will actually lower your vitamin D status as measured by 25-OH vitamin D.

NHE, I'm not sure. I don't recall seeing that word on the front of the bottle but I'll investigate more. EDIT: The ingredient list says magnesium stearate. Would that be it?

No. Magnesium stearate is an additive used as a lubricant to keep the capsule filling machines from getting plugged up.

[kw202]

Well I went ahead and took it, plus an additional 200iu of D3. Feel tons better already, and one of my numb legs is better this morning too. May be psychosomatic, may be the vitamin D, may be natural progression of illness, but whatever it is, I'll take it. Lots more energy is undeniable though.

I called down to the manufacturer and they said the chelating agent on the magnesium is glycinate.