Stem Cell Culture Media Improves EAE

[MStranslate]

STEP 1: Isolate stem cells from extracted baby teeth
STEP 2: Culture and grow these stem cells in the lab
STEP 3: Remove the cells and inject the culture media into mice with EAE

It may seem simple, but a Nagoya University study has shown that doing this results in a significant decrease in the disease severity of mice with EAE (animal model of MS). As the cells themselves weren't injected, this suggests that the benefits of stem cells may go far beyond being able to create new cells to replace damaged ones.

Our full summary can be viewed here: http://www.mstranslate.com.au/stem-cell ... roves-eae/

[NHE]

Hi Brett,

Stem cells from human exfoliated deciduous teeth (SHEDs) are mesenchymal stem cells derived from dental pulp.

Was there any statement indicating why they chose to use baby teeth mesenchymal stem cells as opposed to some other type of mesenchymal stem cell?

[MStranslate]

Hi Brett,

Stem cells from human exfoliated deciduous teeth (SHEDs) are mesenchymal stem cells derived from dental pulp.

Was there any statement indicating why they chose to use baby teeth mesenchymal stem cells as opposed to some other type of mesenchymal stem cell?

Excellent question NHE - there isn't a direct statement in the paper that explains this decision. I assume part of it is easier to obtain cells from teeth that have been extracted rather than from bone marrow.

Other than that, there is some suggestion that the properties observed from the cells derived from this source are slightly different from bone marrow derived mesenchymal stem cells. There is also a suggest that SHEDs contain cells that contain neuroectodermal stem cell markers, as well as the mesenchymal stem cell markers. Hope this helps answer the question a little bit - there have been a few other papers published regarding SHEDs, I'll see if I can find a better answer for you.