David1949 wrote:Leonard where is the proof of that?But recent new insights supported by an abundance of publications in the medical literature change this. MS is no longer that big unknown, is not in its origin a neurological disease, but is a metabolic disease caused by a virus, the herpes virus.
Consider that the Viruses are secondary to the CNS fluid circulation problem, i.e. CCSVIfrodo wrote:
Could be this the explanation of the relationship between CCSVI and MS?
This article points out that endogenous retroviruses that are normally latent reactivate under hypoxia (bad blood flow) conditions.
Investigation of Endogenous Retrovirus Sequences in the Neighborhood of Genes Up-regulated in a Neuroblastoma Model after Treatment with Hypoxia-Mimetic Cobalt Chloride
Human endogenous retroviruses (ERVs) have been found to be associated with different diseases, e.g., multiple sclerosis (MS). Most human ERVs integrated in our genome are not competent to replicate and these sequences are presumably silent.
However, transcription of human ERVs can be reactivated, e.g., by hypoxia. Interestingly, MS has been linked to hypoxia since decades. As some patterns of demyelination are similar to white matter ischemia, hypoxic damage is discussed. Therefore, we are interested in the association between hypoxia and ERVs.
As a model, we used human SH-SY5Y neuroblastoma cells after treatment with the hypoxia-mimetic cobalt chloride and analyzed differences in the gene expression profiles in comparison to untreated cells. The vicinity of up-regulated genes was scanned for endogenous retrovirus-derived sequences.
WAIT A MINUTE !
Before we get too excited about Endogenous Retroviruses (ERVs), allow me to point out that the Epstein Barr Virus (EBV) – cause of Mononucleosis which has struck all MSers -also reactivates in a hypoxia situation. As early as my May 4, 2014 blog post I observed that poor blood flow due to CCSVI reactivates the Epstein Barr Virus and with it MS « attacks». (See Blogs for May 4, 2014 « MS, Body Tension, Oxygen and EBV (Revised), May 23, 2014 « Vit D, Veins and EBV » Oct 12, 2016 « Oxygenate » the Brain, Nov 29, 2017 « MS : Linking Hormones, Diet, Blood Flow, EBV, Myelin Sheath – 2)
So what comes first, the Hypoxia or EBV or ERV ?
There appears to be a pathological need in Western Allopathic medicine to find a drug to "cure" MS. But what if Hypoxia is the main culprit for which there are myriad causes and subsequent « cures » and the « cures » aren’t drug related. So who gets the money ? (Well yes, MS patients often want an easy way out. Take a pill and the problem goes away. Who wants to change their diet and way of life ?)
Below find the 3 principal causes, potential cures, for MS hypoxia in the Central Nervous System/
1.The Chiropractor Dr Michael Flanagan believed that up to 25% of MS cases were caused by skeletal obstructions of blood and cerebro-spinal fluid circulation. Dr. Scott Rosa uses the FONAR upright cine MRI to see the obstructions. Specialty needed ? Usually Chiropractic or Osteopathy.
2. Dr. Zamboni’s CCSVI theory and treatment proposes using angioplasty to enlarge stenosed veins draining the brain/spine in order to free obstructed fluid circulation. Specialty Interventional Radiology
3. Dr. Owiesy observed that when the smooth muscle layers of the CNS veins constrict or go into spasm, they obstruct blood flow. This very critical observation helps correct and enlarge Dr. Zamboni’s CCSVI theory/treatment. It’s not always a problem inside the vein but exterior to it. But it IS a venous blood circulation pathology.
a). Dr. Owiesy proposes administration of a mixture of dexamethasone/lidocaine/thiamine in the area around the Internal Jugular veins to relieve the spasms. (Well, yes these are drugs.)
b). I (and many others) propose a healthy non-inflammatory diet and supplements to prevent toxicity and overcome body tension which basically prevents the spasms and veinous constriction– in my opinion the best, non drug idea.
Currently Neurologists monopolize diagnosis and treatment of MS. They apparently completely ignore the Hypoxia phenomena. They use immune suppressing Disease Modifying Drugs (DMDs). Worse, they believe that early treatment of DMDs assures a better outcome to prevent « attacks ». They don’t consider the three hypoxia issues noted above. MSers get railroaded into treatment which may not be the best solution for them. Physical Therapists in France have told me that the drugs tend to suppress vital energies and that the MSer just gradually declines over time.
So I believe these drugs represent a great misfortune which unnecessarily compounds the MS misfortune. They give the illusion of treatment when in fact the true MS problem is not being addressed. The poor patient gets hooked on drugs before she considers anything else and then the inevitable decline sets in.
See George Ebers research. “Critical Review of outcomes used in MS clinical trials” which was posted on You Tube November 4, 2013 by the European Medicines Agency.
Previously published on my site MSCureEnigmas.net https://www.mscureenigmas.net/