Immunoglobulin G analysis for diagnosis of MS

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High performance of cerebrospinal fluid immunoglobulin G analysis for diagnosis of multiple sclerosis

https://link.springer.com/article/10.10 ... 19-09212-4

Background

The 2017 revision of the McDonald criteria highlights the usefulness of cerebrospinal fluid (CSF) immunoglobulin G (IgG) analysis to diagnose multiple sclerosis (MS). The objective of this study was to assess the diagnostic performances of CSF IgG analysis in the absence of a gold standard.

Conclusions

In the absence of a gold standard, latent class analysis indicates good diagnostic properties of CSF IgG analysis for MS. This test could thus be useful, especially for patients who tested negative for the 2005 and 2010 McDonald criteria. These findings deserve to be confirmed prospectively.