Tropospheric ozone

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Progway 2003

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O3

2025 Mar 5
Environmental pollutant exposure and adverse neurodevelopmental outcomes: An umbrella review and evidence grading of meta-analyses
https://pubmed.ncbi.nlm.nih.gov/40068397/

..Suggestive evidence included the associations between pregnancy O3 exposure and autism spectrum disorder (ASD),..
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MS

August 11, 2024
Autism and Multiple Sclerosis: Can You Have Both? Exploring the Connection
https://neurolaunch.com/can-you-both-be ... sclerosis/

Neurological puzzles collide as two seemingly distinct conditions, autism and multiple sclerosis, intertwine in ways that challenge our understanding of the human brain and spark a quest for answers. The complexity of neurological conditions and their potential coexistence has long intrigued researchers and medical professionals alike. As we delve deeper into the intricacies of the human nervous system, we uncover fascinating connections between disorders that were once thought to be entirely separate entities.

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O3

2023 Aug 25
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Environmental factors and incidence of thyroid cancer in the world (1990-2019): an ecological study
https://pubmed.ncbi.nlm.nih.gov/37624503/

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MS

November 14, 2022
medicalnewstoday.com
The connection between multiple sclerosis and thyroid condition
https://www.medicalnewstoday.com/articl ... s-the-link

..The links between MS and thyroid disorders are unclear, but studies indicate that having one condition may make developing the other more likely.

O3


2022 Jul 8
Association of Ozone Exposures with the risk of thyroid nodules in Hunan Province: a population-based cohort study
https://pmc.ncbi.nlm.nih.gov/articles/PMC9264600/


Background
Increasing evidence associates air pollution with thyroid dysfunction, whereas the potential relationship between exposure to ozone (O3) and Thyroid Nodules (TNs) is unclear...

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MS

2025 Mar 15
Thyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis
https://pubmed.ncbi.nlm.nih.gov/40089493/

Abstract
Multiple sclerosis (MS) is a prevalent neurological disorder with a complex etiology, often associated with thyroid function. However, the causal relationship between these two conditions remains poorly understood. This study aimed to elucidate the causal relationship between thyroid function and MS. ...

..This study provided genetic evidence that FT4 may increase the risk of developing MS. "HLA DR on CD33br HLA DR + CD14" and "IgD- CD27- %B cell", mediated the causal relationship between thyroid function and MS, highlighting the importance of further investigating their roles in these conditions.
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December 2023
The association of multiple sclerosis with thyroid disease: A meta-analysis
https://www.msard-journal.com/article/S ... 1/abstract

Conclusion
This comprehensive meta-analysis establishes a significant association between thyroid diseases and MS, substantiating the increased risk of thyroid disorders in pwMS..

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2025 Mar 17
Temporal and spatial heterogeneity of tropospheric O3 and NO2and health impact analysis in Shaanxi, Gansu, and Ningxia regions of China
https://pubmed.ncbi.nlm.nih.gov/40097847/

Abstract
O3 and precursor pollution in the Shaanxi-Gansu-Ningxia region of China is becoming increasingly severe, and the regional pollution characteristics are also more prominent. To investigate the causes of O3 and NO2 pollution and the health impacts of O3,...

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O3

2021 Nov
Frailty Related to the Exposure to Particulate Matter and Ozone: The Korean Frailty and Aging Cohort Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623935/

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MS

2024 May 27
Falls, fracture and frailty risk in multiple sclerosis: a Mendelian Randomization study to identify shared genetics
https://pubmed.ncbi.nlm.nih.gov/38801451/

O3

23 August 2021
Short-term associations between ground-level ozone exposure and urinary system disease hospital admissions through the emergency room in Beijing, China
https://ehp.niehs.nih.gov/doi/10.1289/isee.2021.P-120

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MS

2025 Mar 18
Frailty and urinary symptoms share pathophysiological mechanisms involved in disease progression in people with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/40100557/

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O3

2024 Apr 18
Long-term exposure to ambient ozone and adult-onset asthma: A prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/38642637/

..Conclusion: Our findings suggest a potential causal relationship between long-term exposure to high-level ambient O3 and increased risks of AOA.
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MS

#ACTRIMS2019 – Asthma More Common in MS Patients Than Public at Large, Study Finds
https://multiplesclerosisnewstoday.com/ ... udy-finds/

.. Asthma is significantly more common among patients with multiple sclerosis (MS) than in the general population, a new study shows. The increased prevalence was especially evident in younger and elderly MS patients, regardless of race or sex.

O3

2025 Mar 19
scRNAseq Identifies Unique Macrophage Population in Mouse Model of Ozone Induced Asthma Exacerbation
https://pubmed.ncbi.nlm.nih.gov/40106801/

..These unique AMs activated gene pathways related to inflammation, sphingolipid metabolism, and bronchial constriction. The unique monocyte population had a gene signature that suggested phospholipase activation and increased degradation of the extracellular matrix..
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MS

10 May 2022
Sphingolipid Players in Multiple Sclerosis: Their Influence on the Initiation and Course of the Disease
https://www.mdpi.com/1422-0067/23/10/5330

Abstract
Sphingolipids (SLs) play a significant role in the nervous system, as major components of the myelin sheath, contributors to lipid raft formation that organize intracellular processes, as well as active mediators of transport, signaling and the survival of neurons and glial cells. Alterations in SL metabolism and content are observed in the course of central nervous system diseases, including multiple sclerosis (MS)...

Free full text.

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O3

2025 Mar 6
Correlation analysis between the prevalence of common respiratory pathogens and exposure to ambient air pollutants in Central China, 2014-2022
https://pubmed.ncbi.nlm.nih.gov/40115343/

..Elevated levels of O3 were found to augment the incidence of MP infection.
Mycoplasma pneumoniae (MP)

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MS

2013 Nov 22
Role of Pathogens in Multiple Sclerosis
https://pmc.ncbi.nlm.nih.gov/articles/PMC4369909/

..Pathogens associated with the development or exacerbation of MS include bacteria, such as Mycoplasma pneumoniae and Chlamydia pneumoniae, the Staphylococcus aureus-produced enterotoxins that function as superantigens, viruses of the herpes virus (Epstein-Barr virus and human herpesvirus 6) and human endogenous retrovirus (HERV)..

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O3

2009 Apr
Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells
https://pmc.ncbi.nlm.nih.gov/articles/PMC3286236/

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MS

2025 Mar 6
IL-6/IL-12 superfamily of cytokines and regulatory lymphocytes play critical roles in the etiology and suppression of CNS autoimmune diseases
https://pubmed.ncbi.nlm.nih.gov/40114923/

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O3

2019 Jul 10
Transcriptional Effects of Ozone and Impact on Airway Inflammation
https://pmc.ncbi.nlm.nih.gov/articles/PMC6635463/

...In addition, high doses of the anti-oxidant N-acetylcysteine (NAC) prevents and reverses ozone-induced lung damage in vivo (12). NAC given prophylactically prevented ozone-induced BAL inflammation (macrophages)..

...Ozone exposure following an infection results in greater survival in males compared to females whereas survival after infection alone is greater in females ..

..Ozone also impacts on AHR and neutrophilic inflammation ..

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MS

2020 Feb 14
N-acetyl Cysteine Administration Is Associated With Increased Cerebral Glucose Metabolism in Patients With Multiple Sclerosis: An Exploratory Study
https://pmc.ncbi.nlm.nih.gov/articles/PMC7033492/

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March 16, 2024
Why Multiple Sclerosis Affects More Women Than Men
https://www.webmd.com/multiple-sclerosi ... e-than-men

Women with MS outnumber men with the condition by nearly 4 to 1. And this gender gap has only widened in the last 50 years. Experts don’t have a clear explanation for the cause of MS in anyone, much less in women specifically. But they have a few theories that might explain the sex differences in MS rates...

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February 22, 2023
Receptor may link gut microbiome to immune system in MS: Study
https://multiplesclerosisnewstoday.com/ ... udy-finds/

The aryl hydrocarbon receptor (AHR) may facilitate or “tune” the crosstalk between the gut microbiome and the immune responses that have been implicated in multiple sclerosis (MS), a new study found...

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March 16, 2024
Why Multiple Sclerosis Affects More Women Than Men
https://www.webmd.com/multiple-sclerosi ... e-than-men

Women with MS outnumber men with the condition by nearly 4 to 1. And this gender gap has only widened in the last 50 years. Experts don’t have a clear explanation for the cause of MS in anyone, much less in women specifically. But they have a few theories that might explain the sex differences in MS rates...

2025 Mar 25
Sex-specific ozone stress responses of poplar: Mechanisms of enhanced tolerance of males
https://pubmed.ncbi.nlm.nih.gov/40157147/


..Overall, the stronger tolerance to O3 in males than females was possibly related to their combined up-regulation of multiple defense pathways that reduce both the oxidative stress and O3 permeability into cytosol.
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O3

2/8/2024
The Association of Air Pollution with New-onset Epilepsy


Rationale: Air pollution has been associated with certain neurological disorders, but its association with epilepsy has been insufficiently explored. Our primary objective was to estimate the association of long-term exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) with new-onset epilepsy among adults in Ontario, Canada. Our secondary objective was to assess whether age, sex, immigration status, and health conditions associated with seizures and epilepsy modify these associations.

Conclusions: We observed a significant negative association between epilepsy onset and NO2 and a significant positive association for O3 in the individual and multi-pollutant models, and a positive association with PM2.5 in the individual pollutant model. Additionally, several characteristics modified the associations of all three air pollutants with new-onset epilepsy. The negative association observed between NO2 and epilepsy may be a result of residual confounding. Future research should continue to explore the associations between specific air pollutants and epilepsy onset.

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MS

2025 Apr 2
Multiple sclerosis and epilepsy
https://pubmed.ncbi.nlm.nih.gov/40180801/

Abstract
Epilepsy is a notable comorbidity in multiple sclerosis (MS), with a prevalence significantly higher than in the general population. This co-occurrence suggests shared pathophysiological mechanisms, including cortical demyelination, chronic inflammation and neurodegeneration, which predispose MS patients to seizures...

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O3

2023 Jan 1
Association between long-term ambient ozone exposure and attention-deficit/hyperactivity disorder symptoms among Chinese children
https://pubmed.ncbi.nlm.nih.gov/36265606/

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MS

2025 Jan 3
Investigating the causal relationships between attention-deficit/hyperactivity disorder and autoimmune diseases: Evidence from Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/40184135/

Abstract
Attention-deficit/hyperactivity disorder (ADHD) and autoimmune diseases have been found to be correlated in the observational studies, but the causal relationships have not been fully investigated. Two-sample Mendelian randomization (MR) analysis was used to explore the causal relationships between ADHD and 8 autoimmune disorders (systemic lupus erythematosus, Crohn disease, ulcerative colitis, type 1 diabetes, rheumatoid arthritis, psoriasis, ankylosing spondylitis [AS], and multiple sclerosis with the publicly available genome-wide association study data in the European

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O3

2024 Apr 18
Long-term exposure to ambient ozone and adult-onset asthma: A prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/38642637/

..Conclusion: Our findings suggest a potential causal relationship between long-term exposure to high-level ambient O3 and increased risks of AOA.
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MS

#ACTRIMS2019 – Asthma More Common in MS Patients Than Public at Large, Study Finds
https://multiplesclerosisnewstoday.com/ ... udy-finds/

.. Asthma is significantly more common among patients with multiple sclerosis (MS) than in the general population, a new study shows. The increased prevalence was especially evident in younger and elderly MS patients, regardless of race or sex.

2025 Apr 1
Early-Life Ozone Exposure and Asthma and Wheeze in Children
https://pubmed.ncbi.nlm.nih.gov/40172886/

Abstract
Importance: Ozone (O3) is the most frequently exceeded air pollutant standard in the US. While short-term exposure is associated with acute respiratory health, the epidemiologic evidence linking postnatal O3 exposure to childhood asthma and wheeze is inconsistent and rarely evaluated as a mixture with other air pollutants.

Conclusions and relevance: In this cohort study with relatively low ambient O3 exposure, early-life O3 was associated with asthma and wheeze outcomes at age 4 to 6 years and in mixture with other air pollutants but not at age 8 to 9 years. Regulating and reducing exposure to ambient O3 may help reduce the significant public health burden of asthma among US children.

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