New formulation of Rebif

[scoobyjude]

Just wondering if anyone is now receiving or have been told when they will receive the new formulation. As far as I know I haven't and I'm wondering if they are waiting till they use up their supplies first.

[bebe]

The new formulation of Rebif is not available in the US yet. It was recently approved by the European Commission and will available soon in other countries....the FDA is taking their own sweet time.

[scoobyjude]

I figured. Thanks for the info.

[liberty]

My neurologist didn't know anything about a new Rebif when I asked him - not sure if it is materially different than that which exits now. I have been taking for nearly 10 years with good success until very recently. He wanted me to consider 3 alternatives (due to an 'intense enhancement' on a recent MRI): Tysabri infusion; Cellcept orally or change to Copaxane. I choose Cellcept but have seen several highly positive comments on-line from those taking Tysabri.
Cheers!

[Jason]

I have talked to the support line and the new formula is approved in Canada, but not available yet.
Probaly have to use up excisting stock piles first.

[dignan]

Jason, thanks for the info. I think you're right about inventory, I've just recently started getting my 4 week supply in 4 separate 3 packs, I assume they have a lot of 3 packs in stock they have to get rid of. I couldn't believe the information about Canadian approval wouldn't be online somewhere. All I found was this, but it confirms what you said:

Brand Name: Rebif
Source: EMD Serono Canada Inc.
Active Ingredient: Interferon beta-1a
Comments: Change in manufacturing process and new product formulation; LIQ(8.8mcg/0.2ml, 22mcg/0.5ml, 44mcg/0.5ml)SC
Date: 2007-09-24
DIN: N/A
Therapeutic Class.: Immunomodulator

http://www.hc-sc.gc.ca/dhp-mps/alt_form ... 2007et.txt

[Punchy]

This may explain why the last two batches I got were defective - damn syringes didn't work properly. Must be from the bottom of the bin ;)

[scoobyjude]

Punchy, the last 3 batches I've received have had faulty syringes too. I couldn't completely push the plunger down. I called the helpline and all they said was-if you can't push it anymore than don't. Great advice huh?

[oreo]

Got a letter from Serono in today's mail - the new fomulation is now on its way to the pharmacies - who will still have to use up existing stocks first.

[dignan]

Thanks for the update Oreo, I've been wondering if it would be out in early 2008.

[Punchy]

I got the same letter - they say we'll recognize the formula because it's in a new coloured box.

I hope it doesn't take too long because I am still having issues with the old Rebif's faulty syringes.

[Grumpster]

I take that crap too, the old one. No faulty syringes yet. I suggest filing a complaint with the MFR about the syringes because then they will have to address it in their Quality Systems. An auditor will have a field day with them if they do not.

What is the substinative change. Does it have anything to do with efficacy, or just a way for them to make more $$ ?

[dignan]

I did my first injection with the new formulation last night. Nothing to report - I didn't get any flu-like symptoms and the shot was relatively painless.

[scoobyjude]

Dignan, is that an improvement for you or just the norm?

[dignan]

I don't ever have side effects. You know how it is with the injections, sometimes they sting, other times they don't. I've done 2 with the new formula so far and no stinging. That could just be luck though. I'll believe it's better after I've done about 10 shots with no stinging.