MS and Uveitis

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
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Nunzio
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MS and Uveitis

Post by Nunzio »

MS classically is described as an autoimmune disorder where the immune system went crazy and started to attach the myelin covering of the nerves.
Considering the eye is he only organ in our body totally devoid of myelin
this doesn't explain why people with MS often have uveitis (an inflammation of the inside of the eye) and more specifically a variant called Pars Planitis.
In addition why is MS attaching only the myelin present in the brain and nowhere else in our body?
Finally CCSVI can explain both of these incongruences.
LR1234
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Post by LR1234 »

I actually think I have this at the moment. I recently had the CCSVI procedure in Poland, I also have had a bad cold and have changed my supplement regime quite drastically to detox so there could be a couple of reasons why I have developed it.

Has anyone else had this condition? Maybe it is related to CCSVI or to heavy metal detox??
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Nunzio
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Post by Nunzio »

Congratulation on your CCSVI treatment.
If you think you have uveitis make sure you are seen by your eye doctor because treating it is very important, no matter what is causing it
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Post by Cece »

I have pars plenitis as well. I am still fuzzy on how CCSVI explains it or if treatment will help it. My understanding of the current explanation of pars plenitis is that it's an autoimmune reaction to the fluid on the inside of the eye. Cheer's recent posting on adhesion molecules of the endothelial cells is of interest. With that, it would be the abnormal venous hydonamics cause an increase in the expression of adhesion molecules of the endothelial cells. With the eye, could this be resulting in the pull of immune cells into the inner part of the eye? And then they spark an autoimmune response...but they shouldn't be there in the first place.
"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition
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Nunzio
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Post by Nunzio »

The way CCSVI explains Uveitis is similar to the explanation for MS.
The increase in venous pressure or the decrease drainage allows iron or other toxin to accumulate inside the eye tissue; then, secondary to the breakdown of the blood brain(eye) barrier, white blood cells penetrate the eye to clean up the mess. Treatment with steroids drops is very important to prevent other problems as increase intraocular pressure (glaucoma) or permanent scarring (synichiae)
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Post by LR1234 »

I wonder why I am getting it now? I did have it slightly before my CCSVI op. I have already been told I have a glucoma risk....maybe I should get it checked out tomorrow.
Last edited by LR1234 on Sun Feb 21, 2010 4:30 pm, edited 1 time in total.
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Post by Cece »

thanks, Nunzio. Any idea whether chelation techniques (green tea, ip6, etc) are able to pull iron out from inside the eye?
"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition
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Post by Nunzio »

I do not think chelation treatment would work for the eye because of the blood brain barrier preventing the chelating agent from entering it.
This assuming uveitis is related to excessive iron deposition which has not been demonstrated for the eye yet.
Drops work perfectly well and there is no reason to try any other treatment.
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