Small study suggests CCSVI may not be involved in MS

MSUK · Post by **MSUK** » Mon Feb 07, 2011 12:41 am

Abstract
Background Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the central nervous system, believed to be triggered by an autoimmune reaction to myelin. Recently, a fundamentally different pathomechanism termed ‘chronic cerebrospinal venous insufficiency’ (CCSVI) was proposed, provoking significant attention in the media and scientific community.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/2944

Billmeik · Post by **Billmeik** » Mon Feb 07, 2011 9:25 am

looks like another bad replication out of germany. The methodology seems ok though. I guess that discussion didn't end in 2010.

NZer1 · Post by **NZer1** » Mon Feb 07, 2011 1:34 pm

I think that Dr. S summed this up quite well;

QUOTE;
mo_en wrote:
Dear doctor,
could you comment on this new, fresh offensive of CCSVI?

http://bit.ly/dRqPnB

Quote Dr. S
I must say that i cannot explain this discrepancy. One would wonder whether respiration is suspended in inspiration or expiration but other than that I just cannot understand how no patients with ms have reflux.I regret that the authors could not perform the gold standard to validate their observations.

In our program reflux is very common on ultrasound. and just as common on venography.

1eye · Post by **1eye** » Mon Feb 07, 2011 2:39 pm

The best way to prove CCSVI exists is to treat a case of it. Invest more than synapse firings and typewriting. I am at least as sick of this incessant unproductive importunate harrying as I ever was with 'MS'. Do they think if they say it enough ways it'll become true?

1eye · Post by **1eye** » Mon Feb 07, 2011 9:26 pm

I was referring to the 'study' (I use quotes because I think calling something a 'study' gives it legitimacy it may not deserve) and I was *not* referring to anything anyone said about it. I think there is too much harassment going on in the pages of reviewed journals. Every time a new study tries quite deliberately to discredit, it gives science a bad name it does not deserve. This whole area of investigation is quite literally being treated as a word war, and real science is surely more detached and civilized.

I am certainly offended that someone would think of an honest discussion as an offensive.

Sorry, I did not click on your link.

concerned · Post by **concerned** » Mon Feb 07, 2011 9:42 pm

I'm pretty sure this was a meticulously designed, triple blinded study. I'm not sure I'd say it was unscientific.

sou · Post by **sou** » Tue Feb 08, 2011 1:47 am

But, anyway, it does not address the issue of what should be done if CCSVI is indeed found to some patient. Should it be left as it is?

What the study authors say is that they haven't found CCSVI. This does not mean that it does not exist but that they haven't found it. Studies that don't find diseases do not make them disappear. If that was the case, I don't even dare to think what would happen if a future study failed to detect gravity. The whole world would get lost in space.

1eye · Post by **1eye** » Tue Feb 08, 2011 6:27 am

Danger, Will Robinson! Danger! Danger!

(For anybody born since 1968, or outside the US, you probably wouldn't have heard of the weird TV show which turned into a spoof of itself: Lost In Space. That was a recurring line spoken by an actor, poor dear, who played a robot.)